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EMIM 2017 - Session Details

PO 02 | Poster Session
Type: Poster Session
Date: April 07, 2017
Time: 13:00 - 15:00
Room: Seminargebäude
Poster walks:
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Room: S-11

PW 13 - Cardiovascular Imaging
Chair: Jeroen Essers & Sophie Hernot
  #PW 13 / 123 Non-invasive volumetric optoacoustic imaging of cardiac perfusion in acute myocardial infarction model
Lin Hsiao-Chun Amy1,2, Déan-Ben Xose Luis1, Kimm Melanie3, Kosanke Katja3, Haas Helena3, Meier Reinhard3, Lohöfer Fabian3, Wildgruber Moritz2,3,4, Razansky Daniel1,2
1Helmholtz Center Munich, Institute for Biological and Medical Imaging (IBMI) - Neuherberg, Germany
2Technical University of Munich, Faculty of Medicine - Munich, Germany
3Technical University of Munich, Department of Diagnostic and Interventional Radiology - Munich, Germany
4Universitätsklinikum Münster, Translational Research Imaging Center, Department of Clinical Radiology - Münster, Germany
 
  #PW 13 / 124 Simultaneous Multiparametric Imaging of the Infarcted Heart
Joevin Sourdon 1, Béatrice Berthon 2, Anikitos Garofalakis 3, Thomas Viel 1, Mickaël Tanter 2, Jean Provost 2, Bertrand Tavitian 1,4
1Paris Descartes University Paris-cardiovascular Research Center, 56 rue leblanc, 75015 Paris, France
2Institut Langevin ESPCI Paris, 17 rue moreau, 75012 Paris, France
3INSERM UMR970 Paris-cardiovascular Research Center, 56 rue Leblanc, 75015 Paris, France
4Hôtpital Européen Georges Pompidou Service de radiologie, 56 rue Leblanc, 75015 Paris, France
 
  #PW 13 / 125 Adverse cardiac remodelling under pressure overload. A Magnetic Resonance Imaging study in mice.
Jacek Kwiecinski 1,2, Ross Lennen 1, Gillian Gray 1, Marc Dweck 1, Maurits Jansen 1
1BHF Centre for Cardiovascular Science University of Edinburgh, Edinburgh, United Kingdom
2First Department of Cardiology Poznan University of Medical Sciences, Poznan, Poland
 
  #PW 13 / 126 Evaluation of Molecular Magnetic Resonance Imaging of Activated Platelets for the Detection and Characterization of Murine Staphylococcus Aureus Endocarditis
Heidt Timo 1, Braig Moritz 2, Huber Patrick 1, Kirschnek Susanne 3, Wadle Carolin 1, Häcker Georg 3, Karlheinz Peter 4, Bode Christoph 1, von Elverfeldt Dominik 2, von zur Mühlen Constantin 1
1Heart Center Freiburg University Dept. for Cardiology and Angiology I - Freiburg, Germany
2University Hospital Freiburg Dept. of Medical Physics - Freiburg, Germany
3University Hospital Freiburg Dept. of Microbiology - Freiburg, Germany
4Baker IDI Heart and Diabetes Institute - Melbourne, Australia
 
  #PW 13 / 127 In vivo imaging of human monocytes in a preclinical model of mouse myocardial infarction
Janette Iking 1, Andreas Borgscheiper 1, Lisa Honold 2, Michael Kuhlmann 2, Sven Hermann 2, Lars Stegger 3, Evangelia Pardali 1, Johannes Waltenberger 1
1University Hospital Münster Dept. of Cardiovascular Medicine, Albert-Schweitzer-Campus 1, 48149 Münster, Germany
2University of Münster Institute for Molecular Imaging (EIMI), Waldeyerstraße 15, 48149 Münster, Germany
3University Hospital Münster Dept. of Nuclear Medicine, Albert-Schweitzer-Campus 1, 48149 Münster, Germany
 
  #PW 13 / 128 Incremental value of detecting metabolic activities with FDG over histology for the identification of inflammatory activities in atherosclerotic plaques of a model of aged ApoE-/- mice
Changjun Yin 1, Zhe Ma 1, Sarajo Mohanta 1, Iina Laitinen 2, Sybille Reder 2, Miriam Mohring 2, Andreas Habenicht 1, Markus Schwaiger 2, Fabien Hyafil 2
1Ludwig-Maximilians University Munich Institute for Cardiovascular Disease Prevention, Pettenkoferstraße 8a & 9, 80336 Munich, Germany
2Klinikum rechts der Isar Nuclear Medicine, Ismaningerstrasse 22, 81675 Munich, Germany
 
  #PW 13 / 129 Spontaneous brain endothelial cell calcium transients measured with a genetically encoded calcium indicator in awake and isoflurane anesthetized mice in vivo.
Adrian Rodriguez-Contreras 1, Lingyan Shi 2
1City University of New York, City College Biology, 160 Convent Avenue, New York, New York 10031, United States
2Columbia University Chemistry, 116 St and Broadway, New York, New York 10027, United States
 
  #PW 13 / 130 Imaging of αVβ3 Integrin Expression in Experimental Myocardial Ischemia with [68Ga]NODAGA-RGD Positron Emission Tomography
Maria Grönman 1, Miikka Tarkia 1, Tuomas Kiviniemi 2, Paavo Halonen 3, Antti Kuivanen 3, Timo Savunen 2,4, Tuula Tolvanen 1, Jarmo Teuho 1, Meeri Käkelä 1, Olli Metsala 1, Mikko Pietilä 2, Pekka Saukko 5, Seppo Ylä-Herttuala 3, Juhani Knuuti 1, Anne Roivainen 1, Antti Saraste 1,2
1University of Turku Turku PET Centre, Kiinamyllynkatu 4-8, 20520 Turku, Finland
2Turku University Hospital Heart Center, Hämeentie 11, 20520 Turku, Finland
3University of Eastern Finland A.I.Virtanen Institute for Molecular Sciences, Neulaniementie 2, 70150 Kuopio, Finland
4University of Turku Research Centre of Applied and Preventive Cardiovascular Medicine, Kiinamyllynkatu 10, 20520 Turku, Finland
5University of Turku Department of Forensic Medicine, Kiinamyllynkatu 10, 20520 Turku, Finland
 
  #PW 13 / 131 Vascular injury promotes changes in plaque composition located distally to the site of injury via increased monocyte infiltration
Begona Lavin Plaza , Alkystis Phinikaridou , Marcelo Andia , Rene Botnar
King's College London Department of Biomedical Engineering, Westminster Bridge Road, St Thomas’ Hospital, Lambeth Wing, London, SE1 7EH, United Kingdom
 
  #PW 13 / 132 Ultra-small Iron Oxide Nanoparticles for Molecular Imaging of Activated Platelets Displaying Unique Dual MRI Contrast
Hang Ta 1, Zhen Li 2, Christoph Hagemeyer 3, Gary Cowin 4, Jathushan Palasubramaniam 5, Xiaowei Wang 5, Karen Alt 3, Peter Karlheinz 5, Andrew Whittaker 1
1University of Queensland Australian Institute for Bioengineering and Nanotechnology, Brisbane Australia
2University of Wollongong Australian Institute of Innovative Materials, Wollongong Australia
3Monash University Australian Centre for Blood Diseases, Melbourne Australia
4University of Queensland Centre for Advanced Imaging, Brisbane Australia
5Baker IDI Heart and Diabetes Institute, Melbourne Australia
 
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Room: S-11

PW 14 - Optical, optoacoustic and ultrasound probes
Chair: Carsten Höltke & Srinivas Banala
  #PW 14 / 133 Optical Molecular Imaging of inflammation using Selectins ligand conjugated to fluorescent liposomes
Isabelle Tardy , Patricia Emmel , Lucille Vallé , Sylvie Henrioud , David Lazarus , Charline Alleaume , Philippe Bussat , Samir Cherkaoui , Thierry Bettinger
BRACCO SUISSE, 31 route de la Galaise, 1228 Plan les ouates, Switzerland
 
  #PW 14 / 134 Detection of microcalcification in atherosclerotic plaques using optical imaging
Alisia Sim 1,2, Cui Lin 2, Fabio Nudelman 1, Marc Dweck 3, Vicky MacRae 2, Alison Hulme 1
1University of Edinburgh EaStCHEM School of Chemistry, David Brewster Road, Edinburgh, EH9 3FJ, United Kingdom
2University of Edinburgh The Roslin Institute, Royal (Dick) School of Veterinary Studies, Easter Bush, Edinburgh, EH25 9RG, United Kingdom
3University of Edinburgh c Centre for Cardiovascular Science / Clinical Research Imaging Centre/ Edinburgh Heart Centre, Little France Crescent, Edinburgh, EH16 4UU, United Kingdom
 
  #PW 14 / 135 Lanthanide-Based Polyaminocarboxylate Complexes as Photostable Probes for Luminescence Imaging within the Near-Infrared Biological Diagnostic Window
Martinić Ivana1,2, Eliseeva Svetlana V.2, Delatouche Regis1,3, Routier Sylvain3, Suzenet Franck3, Petoud Stéphane4,2
1SATT Grand Centre - Clermont-Ferrand, France
2CNRS UPR 4301, Centre de Biophysique Moléculaire - Orléans, France
3University of Orleans, Institute of Organic and Analytical Chemistry - Orléans, France
4University of Geneva, Department of Inorganic, Analytical and Applied Chemistry - Geneva 4, Switzerland
 
  #PW 14 / 136 Cell Penetrating Peptides as tools for the delivery of fluorescent cargoes to the Golgi and a selective subset of breast cancer cells
Felista L. Tansi 1, Yasmin Chaouch 1,2, Eric Kallweit 1,3, Christina Schumann 3, Christoph Kaether 4, Ulf K. Teichgraeber 1, Siegmund Reissmann 5, Ingrid Hilger 1
1Jena University Hospital IDIR-Experimental Radiology, Am Klinikum 1, 07747 Jena, Germany
2Friedrich-Schiller University Jena Department of Chemistry, Jena, Germany
3Ernst-Abbe University of Applied Sciences Medical Technic and Biotechnology, Jena, Germany
4Leibniz Institute for the study of Aging Fritz-Lippmann Institute, 07745 Jena, Germany
5Friedrich-Schiller University Jena Centrum of Molecular Biomedicine, Jena, Germany
 
  #PW 14 / 137 Near-Infrared Chemiluminescence Imaging
Brandon Carney 1,2, Gabriel Büchel 1,3, Brian Zeglis 1,2, Jörg Eppinger 3, Thomas Reiner 1,4
1Memorial Sloan Kettering Cancer Center Radiology, 417 E. 68th St., New York, New York 10065, United States
2Hunter College Chemistry, 695 Park Ave., New York, New York 10065, United States
3King Abdullah University of Science and Technology KAUST Catalysis Center, Thuwal 23955, Saudi Arabia
4Weill Cornell Medical College Radiology, 1300 York Ave, New York, New York 10065, United States
 
  #PW 14 / 138 Ethenylpyrrolyl BODIPY as Novel Near Infrared Ranged Photoacoustic Contrast Agent
Jean Michél Merkes 1, Fabian Kiessling 2, Magnus Rueping 1, Srinivas Banala 1,2
1RWTH Aachen University Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen, Germany
2RWTH Aachen University Institute for Experimental Molecular Imaging, Pauwelsstrasse 30, 52074 Aachen, Germany
 
  #PW 14 / 139 A Novel Temperature Sensor Operating in the OTN-NIR Region Based on Triply Doped NaYF4: Yb, Ho, Er Nanoparticles
Laura Wortmann , Satoru Suyari , Masao Kamimura , Kohei Soga
Tokyo University of Science Department of Materials Science and Technology, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan
 
  #PW 14 / 140 Sinapultide-loaded lipid microbubbles as an ultrasound contrast agent
Dong Liu , Zhiguo Qin , Yang Liu , Fang Yang , Ning Gu
Southeast University School of Biological Science & Medical Engineering, Dingjiaroad number 87, Jiangsu province, Nanjing JS 25, China
 
  #PW 14 / 141 Microbubbles-assisted ultrasound triggers the release of extracellular vesicles from head-and-neck cancer cells
Yuana Yuana 1, Linglei Jiang 2, Bart H.a. Lammertink 1, Pieter Vader 2, Roel Deckers 1, Clemens Bos 1, Raymond M Schiffelers 2, Chrit T Moonen 1
1University Medical Centre Utrecht Imaging, Heidelberglaan 100, 3508 GA Utrecht, Netherlands
2University Medical Centre Utrecht Clinical Chemistry and Hematology, Heidelberglaan 100, 3508 GA Utrecht, Netherlands
 
  #PW 14 / 142 Temporal Assessment of In Vitro Survival, Uptake Efficiency, and Fluorescence of Cardiac Stem Cells Labelled with PLGA-PFCE Nanoparticles and Transfected with FuGENE
Christakis Constantinides 1, Ayman Al Haj Zen 2, Eileen McNeill 2, Hale Ashley 3, Mangala Srinivas 4, Carolyn Carr 5, Jurgen Schneider 6
1Marie Sklodowska Curie Research Fellow Cardiovascular Medicine, Roosevelt Drive, Headington, Oxford, OX37BN, United Kingdom
2Fellow Cardiovascular Medicine, Roosevelt Drive, Headington, Oxford, OX37BN, United Kingdom
3Senior Research Assistant Cardiovascular Medicine, Roosevelt Drive, Headington, Oxford, OX37BN, United Kingdom
4Assistant Professor Tumor Immunology, Radboud University Medical Center (RadboudUMC), Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, Netherlands
5Associate Professor Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT, United Kingdom
6Professor Cardiovascular Medicine, Roosevelt Drive, Headington, Oxford, OX37BN, United Kingdom
 
  #PW 14 / 143 Development of OTN Near-Infrared Fluorescent Probes for Deep Tissue in vivo Imaging in the Second and Third Biological Windows
Masao Kamimura 1,2, Kohei Soga 1,2
1Tokyo University of Science Department of Materials Science and Technology, 6-3-1 Niijuku, Katsushika-ku, Tokyo 1258585, Japan
2Tokyo University of Science Imaging Frontier Center, 6-3-1 Niijuku, Katsushika-ku, Tokyo 1258585, Japan
 
  #PW 14 / 144 Heterobifunctional dyes: Highly Fluorescent Linkers Based on Cyanine Dyes
Virginia Wycisk 1, Katharina Achazi 1, Ole Hirsch 2, Christian Kuehne 3, Jens Dernedde 3, Rainer Haag 1, Kai Licha 1
1Freie Universität Berlin Institute for Chemistry and Biochemistry, Takustr. 3, 14195 Berlin, Germany
2Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany
3Charité-Universitätsmedizin Berlin Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Augustenburger Platz 1, 13353 Berlin, Germany
 
  #PW 14 / 145 Quantum Dot Probes for Intracellular Redox Sensing
Kevin Critchley
University of Leeds School of Physics and Astronomy, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
 
  #PW 14 / 146 Stability measurements and acoustic response of PBCA MB for drug delivery purposes
Lia Appold 1, Jessica Kollarova 1, Jean-Louis Mestas 2, Frederic Padilla 2, Fabian Kiessling 1, Twan Lammers 1
1RWTH Aachen University Clinic ExMI, Pauwelsstraße 30, 52074 Aachen, Germany
2INSERM LabTAU, Cours Albert Thomas, 69424 Lyon, France
 
  #PW 14 / 147 The challenges of quantitative imaging with optoacoustic reporter genes
Joanna Brunker 1,2, Sarah Bohndiek 1,2
1University of Cambridge CRUK Cambridge Institute, Cambridge, CB2 0RE, United Kingdom
2University of Cambridge Department of Physics, Cambridge, CB3 0HE, United Kingdom
 
  #PW 14 / 148 Gold Nanoclusters: design and bioapplications of a novel family of contrast agents
Xavier Le Guevel 1, Estelle Porret 1, Danjin Shen 1, Maxime Henry 1, Lucie Sancey 1, Niko Hildebrandt 2, Rodolphe Antoine 3, Veronique Josserand 1, Jean-Luc Coll 1
1IAB, Rond-point de la Chantourne, 38760 LA Tronche, France
2Institut de Biologie Intégrative de la Cellule (I2BC), Avenue de la Terrasse, 91190 Orsay, France
3Institut Lumière Matière, 5 rue de la Doua, 69100 Villeurbanne, France
 
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Room: S-11

PW 15 - MRI - based probes II
Chair: Juan Pellico & Goran Angelowki
  #PW 15 / 149 Hypoxia and anion responsive cobalt based MR probes
O’Neill Edward S., Kolanowski Jacek L., Bonnitcha Paul, New Elizabeth J.
The University of Sydney, School of Chemistry - Sydney, Australia
 
  #PW 15 / 150 MPI/MRI Oil-in-Water nanoemulsion platform for atherosclerosis diagnosis
Geoffrey Prévot 1, Tina Kauss 1, Cyril Lorenzato 2, Alexandra Gaubert 1, Mélusine Larivière 2, Julie Baillet 1, Jeanny Laroche-Traineau 2, Marie Josée Jacobin-Valat 2, Laurent Adumeau 3, Philippe Barthélémy 1, Martine Duonor-Cérutti 4, Stéphane Mornet 3, Gisèle Clofent-Sanchez 2, Sylvie Crauste-Manciet 1
1Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN : Régulations Naturelle et Artificielle, ChemBioPharm, 146 rue Léo Saignat, 30000 Bordeaux, France
2Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, 14, 30000 Bordeaux, France
3Univ. Bordeaux, CNRS UPR 9048 ICMCB, Institut de Chimie de la Matière Condensée de Bordeaux, 87, Avenue du Docteur Schweitzer, 33600 Pessac, France
4CNRS UPS3044, Baculovirus et Thérapie, 30380 Saint-Christol-lès-Alès, France
 
  #PW 15 / 151 Deoxycholic acid functionalized hexameric GdAAZTA agent for DCE-MRI applications
Lorenzo Tei 1, Dario Livio Longo 2,3, Mauro Botta 1, Giuseppe Gambino 1, Lorena Consolino 4,3
1Università del Piemonte Orientale Dipartimento di Scienze e Innovazione Tecnologica, Viale Teresa Michel 11, 15121 Alessandria, Italy
2Istituto di Biostrutture e Bioimmagini (CNR) Molecular Biotechnology Center, Via Nizza 52, 10126 Torino, Italy
3Molecular Imaging Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
4University of Turin Department of Molecular Biotechnology and Health Science, Via Nizza 52, 10126 Torino, Italy
 
  #PW 15 / 152 Exploiting Dynamic Host:Guest Interactions for 19F-MRI Signal Amplification
Ronit Shusterman-Krush 1, Liat Avram-Biton 2, Amnon Bar-Shir 1
1Weizmann Institute of Science Organic Chemistry, 234 Herzl St., 7610001 Rehovot, Israel
2Weizmann Institute of Science Chemical Research Support, 234 Herzl St., 7610001 Rehovot, Israel
 
  #PW 15 / 153 Nanohydrogels and Gadolinium Chelates: Seeking for Hypersensitive T1 Probes in MRI
Françoise Chuburu 1, Guillaume Rigaux 1, Virginia Gheran 2, Maité Callewaert 1, Sandrine Huclier-Markai 3,4, Cyril Cadiou 1, Juliette Moreau 1, Alexandre Berquand 5, Michael Molinari 5, Sorina Petrache Voicu 2, Anca Dinischiotu 2, Celine Henoumont 6, Luce Vander Elst 6,7, Robert N. Muller 6,7, Sophie Laurent 6,7, Christophe Portefaix 8
1URCA ICMR CNRS 7312, 51100 Reims, France
2UBucharest Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095 Bucharest, Romania
3ARRONAX GIP, 1 rue Arronax, 44817 Nantes, France
4UNantes Laboratoire Subatech, UMR CNRS 6457, 4 Rue A. Kastler, 44307 Nantes, France
5URCA LRN EA 4682, 21 rue Clément Ader, 51100 Reims, France
6UMons NMR and Molecular Imaging Lab., 15 Av. Maistriau, 7000 Mons, Belgium
7CMMI, 8 Rue Adrienne Boland, 6041 Charleroi, Belgium
8CHU Reims Radiology, 45 rue Cognacq-Jay, 51100 Reims, France
 
  #PW 15 / 154 REDOX-RESPONSIVE MRI PROBES TO FOLLOW-UP THE MICROENVIRONMENT WITHIN CELL-EMBEDDING HYDROGELS
Valeria Catanzaro 1, Giuseppe Digilio 1, Federico Capuana 2, Cristina Grange 3, Stefano Porta 3, Carla Carrera 2, Sergio Padovan 4, Nenad Filipovic 5, Magdalena Stevanovic 5
1Università del Piemonte Orientale “Amedeo Avogadro Department of Science and Technologic Innovation, Viale T. Michel 11, 15121 Alessandria, Italy
2Università degli Studi di Torino ​ Department of Molecular Biotechnology and Health Science, via Nizza 52, 10126 Torino, Italy
3Università degli Studi di Torino Department of Medical Sciences, via Nizza 52, 10126 Torino, Italy
4Institute for Biostructures and Bioimages (CNR) Molecular Biotechnology Center, via Nizza 52, 10126 Torino, Italy
5Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Knez Mihailova 35/IV, 1100 Belgrade, Serbia and Montenegro
 
  #PW 15 / 155 Protoporphyrins for Non-Invasive MR Imaging in Tissue Engineering
Nihan Güvener 1,2, Heinz Peter Janke 3, Weiqiang Dou 4, Dorien Tiemessen 3, Silvia Mihaila 3, Sjef Cremers 2, Paul Borm 2, Arend Heerschap 4, Wout F. J. Feitz 3, Egbert Oosterwijk 3, Fabian Kiessling 1
1RWTH Aachen University Institute for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, Pauwelsstrasse 30, 52074 Aachen, Germany
2Nano4Imaging GmbH Zentrum für Biomedizintechnik, Pauwelsstrasse 17, 52074 Aachen, Germany
3Radboud University Medical Center Department of Urology – Experimental Urology, Radboud Institute for Molecular Life Science, Geert Grooteplein Zuid 10, 6525 Nijmegen, Netherlands
4Radboud University Medical Centre Department of Radiology, Geert Grooteplein 10, 6525 Nijmegen, Netherlands
 
  #PW 15 / 156 Tetrameric [Gd(AAZTA)] - system for high sensitivity molecular imaging
Stefania Rachele1, Capuana Federico1, Tripepi Martina1, Gianolio Eliana1, Pagoto Amerigo1, Crizóstomo Kock Flávio Vinícius1,2, Digilio Giuseppe3, Aime Silvio1
1University of Turin, Department of Molecular Biotechnology and Health Sciences - Torino, Italy
2São Paulo University, São Carlos Institute of Chemistry - São Carlos, Brazil
3Università del Piemonte Orientale "A. Avogadro", Department of Science and Technologic Innovation - Alessandria, Italy
 
  #PW 15 / 157 Synthesis, characterization, and relaxation studies of a fluorinated paramagnetic contrast agent.
Laurent Sophie1,2, Hequet Emilie1, Henoumont Celine1, Muller Robert N.1,2, Vander Elst Luce1,2
1UMONS, General, Organic and Biomedical Chemistry - Mons, Belgium
2CMMI, Center for Microscopy and Molecular Imaging - Gosselies, Belgium
 
  #PW 15 / 158 Small BODIPY Probes for Combined Dual 19F MRI and Fluorescence Imaging
Caroline Hoffmann , Gregor Jung
Saarland University Department of Chemistry, Biophysical Chemistry, Campus, 66123 Saarbrücken, Germany
 
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Room: S-11

PW 16 - MRI | Technology, Methodology & Data Analysis
Chair: Dominik von Elverfeldt & Michal Neeman
  #PW 16 / 159 Gd-retention in rat’s brain: assessment of the amounts of insoluble Gd-containing species and intact complex in rat’s brain upon repetitive administrations of GBCAs
Eliana Gianolio 1, Paola Bardini 1,2, Francesca Arena 1,2, Rachele Stefania 1, Enza di Gregorio 1, Silvio Aime 1
1University of Torino Molecular Biotechnologies and Health Science, Via Nizza 52, 10126 Torino, Italy
2University of Torino Excellence Center of Preclinical Imaging, Via Ribes 5, 10010 Colleretto Giacosa - Torino, Italy
 
  #PW 16 / 160 ParaHydrogen Hyperpolarized [1-13C]Pyruvate for metabolic studies on breast cancer cells
Francesca Reineri , Eleonora Cavallari , Carla Carrera , Silvio Aime
University of Torino Molecular Biotechnology and Health Sciences, Via Nizza 52, 10100 Torino, Italy
 
  #PW 16 / 161 Comparison between a single and three ring high resolution PET insert for a preclinical MR system using 7T field strength.
Willy Gsell 1, Antonio Gonzales 2, Cindy Casteels 1, Christophe Deroose 1,3, Carlos Correcher 4, Emilio Gimenez 4, Ralph Wissmann 5, Thorsten Greeb 5, Albert Aguilar 2, Cesar Molinos 4, Ramiro Polo 4, Jose-Maria Benlloch 2, Sven Junge 5, Uwe Himmelreich 1
1University of Leuven Imaging and Pathology, Herestraat 49, 3000 Leuven, Belgium
2Institute for Instrumentation on Molecular Imaging, i3M, Valencia, Spain
3University Hospital Leuven Nuclear Medicine, Herestraat 49, 3000 Leuven, Belgium
4Oncovision, Valencia, Spain
5Bruker BioSpin, Ettlingen, Germany
 
  #PW 16 / 162 A toolbox for nonlinear atlas registration of stroke mouse brain MR images and edema correction of lesion volume
Koch Stefan Paul1, Mueller Susanne1, Foddis Marco1, Bienert Thomas2, von Elverfeldt Dominik2, Knab Felix1, Farr Tracy Deanne1,3, Bernard René1, Dirnagl Ulrich1, Harms Christoph1, Boehm-Sturm Philipp1
1Charité University Medicine Berlin, Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité Core Facility 7T Experimental MRIs, NeuroCure, and German Center for Neurodegenerative Diseases (DZNE) - Berlin, Germany
2University of Freiburg, Department of Radiology, Medical Physics, University Medical Center, and BrainLinks-BrainTools Excellence Cluster - Freiburg, Germany
3University of Nottingham, School of Life Sciences - Nottingham, United Kingdom
 
  #PW 16 / 163 Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging
Syed Salman Shahid 1,2, Robert Gaul 1,2, Christian Kerskens 3, Caitriona Lally 1,2
1Trinity College Dublin Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Dublin Ireland
2Trinity College Dublin Department of Mechanical and Manufacturing Engineering, Dublin Ireland
3Trinity College Dublin Trinity College Institute of Neuroscience, Dublin Ireland
 
  #PW 16 / 164 Hyperpolarization of two tyrosine derivatives using photo-CIDNP
Frederike Euchner 1, Ute Bommerich 1, Rainer Ringleb 1, Joachim Bargon 2, Markus Plaumann 1, Johannes Bernarding 1
1Otto-von-Guericke-University Magdeburg Department for Biometrics and Medical Informatics, Leipziger Str. 44, 39120 Magdeburg, Germany
2University of Bonn Institute of Physical and Theoretical Chemistry, Wegelerstr. 12, 53115 Bonn, Germany
 
  #PW 16 / 165 Collagen scaffolds labelled with MRI and SPECT contrast agents for non-invasive imaging in bone tissue engineering
Eirini Fragogeorgi 1, Julian Daich 2, Eleftherios Fysikopoulos 3, Simon Lacroix 4, Gilles Doumont 4, Maria Georgiou 3, Dimitri Stanicki 5, Marcos Pita 6, Sophie Laurent 4,5, Penelope Bouziotis 1, Marisela Velez 6, George Loudos 1,7
1National Center for Scientific Research (NCSR) “Demokritos” Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, Patriarchou Grigoriou & Neapoleos, 15310 Aghia Paraskevi - Athens, Greece
2Bioimag Soluciones de Contraste, Carretera N-521, 10071 Caceres, Spain
3BioEmission Technology Solutions, Alexandras Avenue 116, 11472 Athens, Greece
4Center for Microscopy and Molecular Imaging (CMMI), Rue A. Bolland, 8, 6041 Gosselies, Belgium
5University of Mons General, Organic and Biomolecular Imaging Unit, Place du Parc, 21, 7000 Mons, Belgium
6CSIC Instituto de Catálisis y Petroleoquímica, Marie Curie, 2, L10, 28049 Madrid, Spain
7Technological Educational Institute of Athens (TEIA) Department of Biomedical Engineering, Ag. Spyridonos 28, 12210 Egaleo-Athens, Greece
 
  #PW 16 / 166 MRI characterization of engineered cartilage tissue grafts
Maja Pusic 1, Sinisa Skokic 2, Rudolf Vukojevic 3, Andreja Vukasovic 4, Petar Kostesic 5, Mirta Seletkovic 5, Drazen Vnuk 5, Drazen Maticic 5, Inga Marijanovic 1, Alan Ivkovic 6,7
1University of Zagreb, Faculty of Science Department of Molecular Biology, 10000 Zagreb, Croatia
2University of Zagreb, School of Medicine Croatian Institute for Brain Research, Salata 12, 10000 Zagreb, Croatia
3University Clinical Hospital Centre Sestre Milosrdnice Department of Diagnostic and Interventional Radiology, 10000 Zagreb, Croatia
4University of Zagreb, School of Medicine Department of Histology and Embryology, 10000 Zagreb, Croatia
5University of Zagreb, Faculty of Veterinary Medicine Clinic for Surgery, Orthopedics and Ophthalmology, 10000 Zagreb, Croatia
6University Hospital Sveti Duh Department of Orthopedics, 10000 Zagreb, Croatia
7University of Rijeka Department of Biotechnology, 10000 Zagreb, Croatia
 
  #PW 16 / 167 Multicolor 19F-MRI optimized for cell tracking
Cristina Chirizzi 1, Davide de Battista 1, Ilaria Tirotta 2, Pierangelo Metrangolo 2, Giancarlo Comi 1, Francesca Baldelli Bombelli 2, Linda Chaabane 1
1San Raffaele Hospital Institute of Experimental Neurology (INSPE), Division of Neuroscience, via olgettina,60, 20132 Milan, Italy
2Politecnico di Milano Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”, Via L. Mancinelli, 7, 20131 Milan, Italy
 
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Room: S-11

PW 17 - Optoacoustics & Ultrasound | Technology, Methodology & Data Analysis
Chair: Fabian Kiessling & Veronique Josserand
  #PW 17 / 168 The effect of low frequency noise power on: effective bandwidth, sensitivity, and artifacts, in photoacoustic imaging
Jang Hwan Cho 1, Liji Cao 2, Michael Thornton 1
1Endra Inc., 3600 Green Court, Suite 350, Ann Arbor, MI 48105, United States
2inviscan, 23 rue du Loess - BAT 25, 67037 Strasbourg cedex 2, France
 
  #PW 17 / 169 Real-time imaging of superficial vasculature using a LED-based photoacoustic/ultrasound imaging system
Mithun Kuniyil Ajith Singh 1, Yusuke Shigeta 2, Naoto Sato 2, Toshitaka Agano 2
1PreXion Corporation Research and Business Development Division, Stationsplein 45, A4.004, 3013 AK Rotterdam, Netherlands
2PreXion Corporation Research and Development Division 1, Funai Tokyo technology center Building, 1-14-1 Kandasuda-cho, Tokyo 101-0041, Japan
 
  #PW 17 / 170 Brain Metastases Exploration by Endogenous Contrast Photoacoustic Imaging
Lavaud Jonathan1,2,3, Henry Maxime1,2,3, Coll Jean-Luc1,2,3, Josserand Veronique1,2,3
1INSERM U1209, Institute For Advanced Biosciences, - Grenoble, France
2Univ. Grenoble Alpes - Grenoble, France
3OPTIMAL, Small animal imaging facility - Grenoble, France
 
  #PW 17 / 171 Ultrasound Ultrafast Doppler functional imaging reveals a brain connectivity deficit in an intra-uterine growth restriction model that can be mitigated by an ocytocin agonist.
Charlie Demené 1, Jérôme Mairesse 2, Julien Pansiot 2, Olivier Baud 2,3, Mickaël Tanter 1
1Institut Langevin, CNRS UMR 7587, Inserm U979, ESPCI Paris, PSL Research University, Paris, France
2Inserm unit U1141, Robert Debré University Hospital, Paris, France
3Assistance Publique - Hôpitaux de Paris, Neonatal Intensive Care Unit, Inserm U1141, Fondation PremUp, Robert Debré University Hospital,, Paris, France
 
  #PW 17 / 172 Quantitative Acoustic Attenuation Imaging of Soft-Tissues
Joaquin L. Herraiz , Mailyn Perez-Liva , Jose Manuel Udias
University Complutense of Madrid Atomic, Molecular and Nuclear Physics, Av. Complutense s/n. Facultad Ciencias Fisicas, 28040 Madrid, Spain
 
  #PW 17 / 173 Combined FDG-PET and high frame rate ultrasound imaging for perfusion, metabolic activity, and tissue elasticity mapping of rat hearts in vivo
Béatrice Berthon 1, Joevin Sourdon 2, Anikitos Garofalakis 2, Thomas Viel 2, Mickaël Tanter 1, Bertrand Tavitian 2,3, Jean Provost 1
1ESPCI Paris, PSL Research University, CNRS UMR 7587, INSERM U979 Institut Langevin, 17 rue Moreau, F-75012 Paris, France
2Paris-Cardiovascular Research Center, Descartes University, Inserm U970, 56 Rue Leblanc, 75015 Paris, France
3Hôpital Européen Georges Pompidou, APHP, Paris, France
 
  #PW 17 / 174 Radiomic analysis of contrast-enhanced ultrasound data
Benjamin Theek , Tatjana Opacic , Twan Lammers , Fabian Kiessling
RWTH Aachen University Clinic Department for Experimental Molecular Imaging, Pauwelsstr. 30, 52074 Aachen, Germany
 
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Room: S-11

PW 18 - Mass Spectrometry | Technology, Methodology & Data Analysis
Chair: John Fletcher & Giannis Zacharakis
  #PW 18 / 175 FTIR-guided tissue annotation of Matrix-assisted Laser Desorption/Ionization - Mass Spectrometry Imaging (MALDI-MSI) data
Jan-Hinrich Rabe 1, Sandra Schulz 1, Martina Ott 2, Katharina Ochs 2, Michael Platten 2, Christiane Opitz 3, Carsten Hopf 1
1University of Applied Sciences Mannheim Biotechnology, Paul-Wittsack Str. 10, 68163 Mannheim, Germany
2Universitätsklinikum Heidelberg Neurologische Klinik, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
3Deutsches Krebsforschungszentrum Hirntumor-Metabolismus, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
 
  #PW 18 / 177 Mass Spectrometry Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery
Ann-Christin Niehoff 1,2, Sabrina Kröger 2, Astrid Jeibmann 3, Walter Stummer 4, Uwe Karst 2
1Shimadzu Europa GmbH Innovation Center - Imaging, Albert-Hahn-Str. 6-10, 47269 Duisburg, Germany
2University of Münster Institute of Inorganic and Analytical Chemsitry, Corrensstr. 30, 48149 Münster, Germany
3University Hospital Münster Institute of Neuropathology, Pottkamp 2, 48149 Münster, Germany
4University Hospital Münster Department of Neurosurgery, Albert-Schweizer-Campus 1, 48149 Münster, Germany
 
  #PW 18 / 178 Sublimation as matrix application technique for matrix assisted laser desorption (MALDI) mass spectrometry imaging (MSI) in pharmacological studies
Lennart Huizing 1, Rob Vreeken 2,1, Ron Heeren 1
1Maastricht University M4I institute, Universiteitssingel 50, 6229ER Maastricht, Netherlands
2Janssen R&D, Turhoutseweg 30, 2340 Beerse, Belgium
 
  #PW 18 / 179 Investigation of molecular heterogeneity of head and neck cancer in MALDI-MSI preparations
Grzegorz Mrukwa 1, Monika Pietrowska 2, Piotr Widlak 2, Joanna Polanska 1
1Politechnika Śląska Data Mining Group, Akademicka, 2A, 44-100 Gliwice, Poland
2Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Oddział w Gliwicach, Wybrzeże Armii Krajowej 15, 44-100 Gliwice, Poland
 
  #PW 18 / 180 Correlation of 3D Histology and 3D Molecular Imaging
Herbert Thiele 1, Judith Lotz 1, Johannes Lotz 1, Franziska Hofmann 2, Günther Ernst 2, Orlando Guntinas-Lichius 3, Ferdinand von Eggeling 2,3
1Fraunhofer MEVIS Inst. Medical Image Computing, Maria-Goeppert-Str. 3, 23562 Lübeck, Germany
2Friedrich Schiller University Jena Institute of Physical Chemistry, Jena, Germany
3Jena University Hospital ENT Department, Jena, Germany
 
  #PW 18 / 181 Mass spectrometry imaging of human orthotopic pancreatic tumor xenografts for lipid profile characterization
Pierzchalski Keely1, Napp Joanna2,3, Missbach-Guentner Jeannine2,3, Pinkert-Leetsch Diana3, Alves Frauke2,3, Heeren Ron1
1Maastricht University, Maastricht Multimodal Molecular Imaging Institute (M4I) - Maastricht, Netherlands
2University Medical Center Goettingin, Department of Haematology and Medical Oncology - Gottingen, Germany
3University Medical Center Goettingin, Institute of Diagnostic and Interventional Radiology - Gottingen, Germany
 
  #PW 18 / 182 Multimodal imaging of lipids in a zebrafish melanoma model by PET and DESI-MS
Jones Emrys1, Henderson Fiona2, Hart Philippa1, Hurlstone Adam3, Foster Duncan2, Johnston Hannah2, Williams Kaye J.3, McMahon Adam2, Claude Emmanuelle1
1Waters Corporation - Wilmslow, United Kingdom
2Wolfson Molecular Imaging Centre - Manchester, United Kingdom
3The University of Manchester - Manchester, United Kingdom
 
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Room: S-12

PW 19 - Immunology & Inflammation | Inflammatory Responses
Chair: Martin Gotthardt & Ferdinand Knieling
  #PW 19 / 183 Delivery of glucocorticoids to the lungs of mice with acute allergic inflammation using fluorescent inorganic-organic hybrid nanoparticles
Joanna Napp 1,2, Joachim G. Heck 3, Andrea M. Markus 4, Christian Dullin 1, Claus Feldmann 3, Frauke Alves 1,2
1University Medical Center Goettingen UMG Institute of Diagnostic and Interventional Radiology, Robert Koch Str. 40, 37075 Göttingen, Germany
2University Medical Center Goettingen UMG Hematology and Medical Oncology, Robert Koch Str. 40, 37075 Göttingen, Germany
3Karlsruhe Institute of Technology (KIT) Institute of Anorganic Chemistry, Engesserstraße 15, Building 30.45,, 76131 Karlsruhe, Germany
4MPI of experimental Medicine, Hermann Rein Str. 3, 37075 Göttingen, Germany
 
  #PW 19 / 184 Fluorescence molecular imaging of cathepsin activity as a novel biomarker for giant cell arteritis
Jana Humbert 1, Sanjay Tiwari 2, Antje Müller 3, Dirk Duwendag 4, Konstanze Holl-Ulrich 5, Carola Heneweer 6, Patrick Meyer 1, Elfriede Fritzer 7, Georg Lutter 8, Johann Oltmann Schröder 9, Claus-Christian Glüer 2, Olav Jansen 1, Marcus Both 1
1Universital Hospital Schleswig-Holstein, Campus Kiel Department of Radiology and Neuroradiology, Arnold-Heller-Straße 3, 24105 Kiel, Germany
2Universital Hospital Schleswig-Holstein, Campus Kiel Department of Radiology and Neuroradiology, MOIN CC, Am Botanischen Garten 14, 24105 Kiel, Germany
3Universital Hospital Schleswig-Holstein, Campus Lübeck Department of Rheumatology, Ratzeburger Allee 160, 23538 Lübeck, Germany
4Universital Hospital Schleswig-Holstein, Campus Kiel Department of Ophthalmology, Arnold-Heller-Straße 3, 24105 Kiel, Germany
5Universital Hospital Schleswig-Holstein, Campus Lübeck Department of Pathology, Ratzeburger Allee 160, 23538 Lübeck, Germany
6Universital Hospital Cologne Institute for Diagnostic and Interventional Radiology, Kerpener Str. 62, 50937 Köln, Germany
7Universital Hospital Schleswig-Holstein, Campus Kiel Institute for Medical Informatics and Statistics, Brunswiker Str. 10, 24105 Kiel, Germany
8Universital Hospital Schleswig-Holstein, Campus Kiel Department of Heart and Vascular Surgery, Arnold-Heller-Straße 3, 24105 Kiel, Germany
9Universital Hospital Schleswig-Holstein, Campus Kiel Department of Internal Medicine I, Arnold-Heller-Straße 3, 24105 Kiel, Germany
 
  #PW 19 / 185 Therapeutic targeting of hepatic macrophages by hard-shell microbubbles for the treatment of liver inflammation
Klaudia Warzecha 1, Matthias Bartneck 1, Diana Möckel 2, Fabian Kiessling 2, Christian Trautwein 1, Twan Lammers 2, Frank Tacke 1
1University Hospital Medical clinic III, Pauwelsstraße 30, 52074 Aachen, Germany
2RWTH Aachen University Institute for Experimental Molecular Imaging, Helmholtz Institute for Biomedical Engineering, Pauwelsstraße 30, 52074 Aachen, Germany
 
  #PW 19 / 186 PET imaging of 64Cu-NOTA labeled platelet glycoprotein VI (GPVI): towards a new tracer for imaging of sterile inflammation
1, Maurer Andreas1, Schwenck Johannes1,2, Schaller Martin3, Brauchle Eva4,5, Schenke-Layland Katja4,5,6, Kneilling Manfred1,3, Pichler Bernd J.1
1University of Tübingen, Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy - Tübingen, Germany
2University of Tübingen, Department of Nuclear Medicine - Tübingen, Germany
3University of Tübingen, Department for Dermatology - Tübingen, Germany
4Research Institute for Women’s Health Eberhard Karls University Tübingen, Department of Women’s Health - Tübingen, Germany
5Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Department of Cell and Tissue Engineering - Stuttgart, Germany
6University of California, Department of Medicine/Cardiology, Cardiovascular Research Laboratories - Los Angeles, United States
 
  #PW 19 / 187 Tristetraprolin expression by keratinocytes controls local and systemic inflammation
Gilles Doumont 1, Mathieu Andrianne 2
1Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles nuMIx, 8, rue Adrienne Bolland, B-6041 Charleroi (Gosselies), Belgium
2Université Libre de Bruxelles (ULB) Institute for Medical Immunology (IMI), 8, rue Adrienne Bolland, B-6041 Charleroi (Gosselies), Belgium
 
  #PW 19 / 188 Canonical NF-κB activation modulates leucocyte recruitment and oxidative stress during acute and chronic cutaneous delayed-type hypersensitivity reaction (DTHR)
Mehling Roman1, Schwenck Johannes2,3, Schörg Barbara1, Altmeyer Natalie2, Halit-Öz Hasan4, Hartl Dominik4,5, Carlsen Harald6, Röcken Martin7, Pichler Bernd J.1, Kneilling Manfred2,7
1Werner Siemens Imaging Center, Preclinical Imaging and Radiopharmacy - Tübingen, Germany
2Werner Siemens Imaging Center, Preclinical Imaging and Radiopharmacy - Tübingen, Germany
3University of Tübingen, Department of Nuclear Medicine - Tübingen, Germany
4University of Tübingen, Department of Pediatrics I - Tübingen, Germany
5Roche Innovation Center Basel, Immunology, Inflammation and Infectious Diseases - Basel, Swaziland
6Norwegian University of Life Sciences, Department of Chemistry - Ås, Norway
7University of Tübingen, Department of Dermatology - Tübingen, Germany
 
  #PW 19 / 189 X-ray based lung function measurement reveals persistent loss of lung tissue elasticity in mice recovered from allergic airway inflammation
Markus Andrea M.1, Borowik Sergej2, Reichardt Marius2, Tromba Giuliana3, Alves Frauke1,2,4, Dullin Christian3,4
1Max-Planck-Institute for Experimental Medicine - Göttingen, Germany
2University Medical Center Göttingen, Institute for Hematology and Medical Oncology - Göttingen, Germany
3Synchrotron Light Source ‘Elettra’ - Trieste, Italy
4University Medical Center Göttingen, Institute of Diagnostic and Investigative Radiology - Göttingen, Germany
 
  #PW 19 / 190 Characterization of cellular sources of reactive oxygen species (ROS) in vivo by non invasive Optical imaging with chemiluminescence L-012 and Lucigenin in acute and chronic contact hypersensitivity
Schwenck Johannes1,2, Mehling Roman1, Thaiss Wolfgang1,3, Altmeyer Natalie4,1, Carlsen Harald5, Röcken Martin6, la Fougere Christian2, Pichler Bernd J.1, Kneilling Manfred1,6
1Eberhard Karls University, Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy - Tübingen, Germany
2Eberhard Karls University, Department of Nuclear Medicine - Tübingen, Germany
3Eberhard Karls University, 3Department of Diagnostic and Interventional Radiology - Tübingen, Germany
4Eberhard Karls University, 1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy - Tübingen, Germany
5Norwegian University of Life Sciences, Department of Chemistry, Biotechnology and Food Science - Ås, Norway
6Eberhard Karls University, Department of Dermatology - Tübingen, Germany
 
  #PW 19 / 191 Using MALDI Mass Spectrometry Imaging to visualise the distribution of a potential anti-inflammatory candidate in the eye
Laura Mairs 1, Diego Cobice 1, Logan MacKay 2, Kathleen Christie 1, Andrew Nesbit 1, Tara Moore 1
1Ulster University Centre for Molecular Biosciences, Biomedical Science, Cromore Road, Coleraine, BT52 1SA, United Kingdom
2University of Edinburgh SIRCAMS, School of Chemistry,, West Mains Road, Joseph Black Building, The King’s Buildings, Edinburgh, EH9 3JJ, United Kingdom
 
  #PW 19 / 192 Labeling of immune cells and their non-invasive monitoring using cationic 19F emulsion: a step towards mechanistic studies of type1 diabetes pathogenesis
Shweta Saini 1, Sayuan Liang 2,1, Hannelie Korf 3, Rein Verbeke 4, Ine Lentacker 4, Stefaan de Smedt 4, Chantal Mathieu 5, Uwe Himmelreich 6
1KU Leuven Imaging and Pathology, Herestraat 49, Bus 505, 3000 Leuven, Belgium
2University of Antwerpen, 2610 Antwerp, Belgium
3KU Leuven Translational Research in GastroIntestinal Disorders, Leuven, Belgium
4University of Gent Laboratory for General Biochemistry and Physical Pharmacy, Gent, Belgium
5KU Leuven Clinical and Experimental Endocrinology, Leuven, Belgium
6KU Leuven Imaging and Pathology, Herestraat 49, Bus 505, 3000 Leuven, Belgium
 
  #PW 19 / 193 In vivo CEST MRI of specific activated T-cells population using the natural nucleoside cytidine
Hyla Allouche-Arnon 1, Amnon Bar-Shir 2
1Weizmann institute of science Organic Chemistry, Hertzel 234, 7630803 Rehovot, Israel
2Weizmann institute of science Organic Chemistry, Hertzel 234, 7630803 Rehovot, Israel
 
  #PW 19 / 194 Photodynamic therapy in rheumatoid arthritis; targeting activated fibroblasts in vitro.
Daphne Dorst 1, Mijke Buitinga 1, Maarten Brom 1, Desirée Bos 1, Birgitte Walgreen 2, Christian Klein 3, Marije Koenders 2, Martin Gotthardt 1
1Department of Radiology and Nuclear Medicine Radboud university medical center, Nijmegen, Netherlands
2Department of Experimental Rheumatology Radboud university medical center, Nijmegen, Netherlands
3Roche Innovation Center, Zurich, Austria
 
  #PW 19 / 195 Osteopontin attenuates secondary neurodegeneration in the thalamus and striatum after experimental stroke
Ladwig Anne1, Rogall Rebecca1, Hucklenbroich Jörg1, Willuweit Antje2, Schöneck Michael2, Langen Karl-Josef2, Fink Gereon Rudolf1,3, Rueger Maria Adele1,3, Schroeter Michael1,3
1University Hospital of Cologne, Department of Neurology - Köln, Germany
2Research Centre Juelich, Medical Imaging Physics, Institute of Neuroscience and Medicine (INM-4) - Juelich, Germany
3Research Centre Juelich, Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3) - Juelich, Germany
 
  #PW 19 / 196 Longitudinal monitoring of S100A9 and activated MMPs in the induction and development of a Rheumatoid Arthritis model by FRI
Mitchell Duffy 1,2, Stefanie Zenker 3, Mahesh Kondapuram 1,3, Andreas Faust 1,2, Johannes Roth 3,2, Thomas Vogl 3,2, Michael Schäfers 1,2,4, Sven Hermann 1,2
1University of Muenster European Institute for Molecular Imaging (EIMI), Waldeyerstrasse 15, 48149 Muenster, Germany
2Cells in Motion (CiM) Cluster of Excellence, Muenster, Germany
3University of Muenster Institute of Immunology, Muenster, Germany
4University Hospital Muenster Department of Nuclear Medicine, Muenster, Germany
 
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Room: S-12

PW 23 - Imaging the microenvironment
Chair: Olivier Clement & Isabel Quiros Gonzalez
  #PW 23 / 227 Visualization of the recruitment of 64Cu-NOTA-CD11b-labeled myeloid-derived suppressor cells to the primary and metastatic tumor microenvironment by PET/MRI
Hoffmann Sabrina H L1, Reck Dorothea I1, Maurer Andreas1, Sceneay Jaclyn E2, Wong Christina S F2, Ehrlichmann Walter1, Reischl Gerald1, Kneilling Manfred1,3, Möller Andreas2, Pichler Bernd J.1, Griessinger Christoph1
1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen - Tübingen, Germany
2Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute - Brisbane, Australia
3Department of Dermatology, Eberhard Karls University Tübingen - Tübingen, Germany
 
  #PW 23 / 228 Metabolic stability of stromal tumor environment with HPLC, MALDI and in vivo [18F]FDG-PET imaging in a Patient Derived Transplanted Xenograft mouse model : a quantitative assessment
Andrei Turtoi 1, Arnaud Blomme 1, Gilles Doumont 2, Félicie Sherer 2, Serge Goldman 2,3, Pierre Lovinfosse 4, Ana Perez Palacios 5, Costanza Brunella 5, Edwin de Pauw 6, Touko Hirano 7, Yukihiro Otaka 8, Justine Bellier 5, Philippe Delvenne 9, Olivier Detry 10, Sébastien Boutry 11, Masahiko Nishiyama 8, Gaetan van Simaeys 2,3, Vincenzo Castronovo 5
1University of Liège Metastasis Research Laboratory, GIGA Cancer, 4000 Liège, Belgium
2Université Libre de Bruxelles Center for Microscopy and Molecular Imaging, Charleroi, Belgium
3Université Libre de Bruxelles Hôpital Erasme, Department of Nuclear Medicine, 1070 Brussels, Belgium
4University of Liège University Hospital, Department of Nuclear Medicine and Oncologic Imaging, 4000 Liège, Belgium
5Metastasis Research Laboratory GIGA Cancer, University of Liège, 4000 Liège, Belgium
6University of Liège Laboratory of Mass Spectroscopy, 4000 Liège, Belgium
7Gunma University Graduate School of Medicine Laboratory for Analytical Instruments, Education and Research Support Center, Gunma 371-8511, Japan
8Gunma University Graduate School of Medicine Department of Molecular Pharmacology and Oncology, Gunma Japan
9University of Liège University Hospital, Department of Pathology, 4000 Liège, Belgium
10University of Liège University Hospital, Department of Abdominal Surgery, 4000 Liège, Belgium
11University of Mons 10NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, 7000 Mons, Belgium
 
  #PW 23 / 229 Detection of Chemokine Containing Microparticles in the Tumor Microenvironment by Intravital Third Harmonic Generation Microscopy
Gert-Jan Bakker 1, Bettina Weigelin 2,1, Peter Friedl 1,2
1Radboud Institute for Molecular Life Sciences Dept. of Cell Biology and Microscopic Imaging Centre, Geert Grooteplein 28, 6525GA Nijmegen, Netherlands
2David H. Koch Center for Applied Research of Genitourinary Cancers Department of Genitourinary Medical Oncology – Research, The University of Texas MD Anderson Cancer Center, Houston, Texas TX 77030, United States
 
  #PW 23 / 230 In vivo visualisation of vessel formation in peritoneal tumour scaffolds with µCT
Emiel de Jaeghere 1, Elly de Vlieghere 1,2, Sara Neyt 3, Bert Vandeghinste 3, Jasper van Hoorick 4, Glenn Wagemans 1, Leen Pieters 5, Elodie Melsens 6, Geert Berx 7,8, Sandra van Vlierberghe 4, Wim Ceelen 6, Heidi Declercq 4, Christian Vanhove 9, Olivier de Wever 1,2
1Ghent University Laboratory of Experimental Cancer Research, De Pintelaan 185, 9000 Gent, Belgium
2Ghent University Cancer Research Institute Ghent (CRIG), De Pintelaan 185, 9000 Gent, Belgium
3MOLECUBES NV, MeetDistrict - Ghelamco Arena Ottergemsesteenweg Zuid 808 bus 325, 9000 Gent, Belgium
4Ghent University Polymer Chemistry and Biomaterials Group, Department of Organic Chemistry, Krijgslaan 281, S4, 9000 Gent, Belgium
5Ghent University Department of Basic Medical Science, De Pintelaan 185, 6B3, 9000 Gent, Belgium
6Ghent University Hospital Department of Surgery, De Pintelaan, 185 9000, Belgium
7VIB Unit of Molecular and Cellular Oncology, Inflammation Research Center, Technologiepark Zwijnaarde 927, VIB, 9052 Zwijnaarde, Belgium
8Ghent University Department of Biomedical Molecular Biology, Technologiepark Zwijnaarde 927, VIB, 9052 Zwijnaarde, Belgium
9Ghent University Institute Biomedical Technology - Medical Imaging and Signal Processing, De Pintelaan 185 B5, 9000 Gent, Belgium
 
  #PW 23 / 231 Connecting tumor microenvironmental factors to therapeutic response of drug delivery by thermosensitive liposomes
Wouter Lokerse 1, Michiel Bolkestein 2, Alexander Eggermont 3, Marion de Jong 4, Holger Gruell 5, Gerben Koning 2
1Ludwig Maximilian University University Clinic Grosshadern, Marchioninistrasse 15, 81377 Munchen, Germany
2Erasmus Medical Center Surgery, 's-Gravendijkwal 230, 3015CE Rotterdam, Netherlands
3Institut Gustave Roussy, Villejuif, France
4Erasmus Medical Center Nuclear Medicine & Radiology, 's-Gravendijkwal 230, 3015CE Rotterdam, Netherlands
5University of Cologne Radiology, Kerperner strasse 62, 50937 Cologne, Germany
 
  #PW 23 / 232 Protease-dependent optical in-vivo imaging of macrophages and further characterization of the tumor-microenvironment in tumors of different metastatic capability.
Nils Große Hokamp 1, Fabian Flores-Borja 2,3, Christiane Geyer 4, Walter Heindel 4, Thomas Vogl 5, Michel Eisenblätter 4,6,2
1University Hospital of Cologne Department for Diagnostic and Interventional Radiology, Kerpener Straße 62, 50937 Colognge, Germany
2King's College London Richard Dimbleby Department of Cancer Research, SE1 1UL, London, United Kingdom
3King's College London Breast Cancer Now Research Unit, Department of Research Oncology, SE1 9RT, London, United Kingdom
4University Hospital Münster Institute for Clinical Radiology, Albert-Schweitzer-Campus 1, 48149 Münster, Germany
5University Hospital Münster Institute of Immunology, Albert-Schweitzer-Campus 1, 49149 Münster, Germany
6King's College London Division of Imaging Sciences & Biomedical Engineering, SE1 7EH, London, United Kingdom
 
  #PW 23 / 233 Intratumoral activity distribution over time in a radioimmunotherapy mouse model targeting hK2 in prostate cancer xenografts
Anders Örbom 1, Sven-Erik Strand 1,2, Oskar Vilhelmsson Timmermand 1
1Lund University Department of Clinical Sciences Lund, Oncology and Pathology, Lund, Sweden
2Lund University Department of Clinical Sciences Lund, Medical Radiation Physics, Lund, Sweden
 
  #PW 23 / 235 Identification of apoptosis-targeting peptide-2 using phage displayed peptide library and its application to in vivo imaging of apoptosis
Mohammad Enamul Haque , Napolean Bonaparte , Byungheon Lee
Kyungpook National University, School of Medicine Department of Biochemistry and Cell Biology, gukchaebosang-ro, Jung-gu, Daegu 41944, Korea Republic (South)
 
  #PW 23 / 236 High Frequency Shear-Wave Elasticity Measurements in Matrix of a 3D Gastric Cancer Invasion Model
Yo-Ping Lai 1, Yung-Shao Yang 2, Liji Cao 3, Pai-Chi Li 2
1National Taiwan University Hospital Internal Medicine, Taipei Taiwan
2National Taiwan University, Taipei Taiwan
3S-Sharp, New Taipei Taiwan
 
  #PW 23 / 237 Lentivectors as a tool for inflammation-regulated optical imaging
Guillermo Garaulet Perez 1, Cristina Lorenzo 2, Jorge L. Martinez-Torrecuadrada 3, Antonio Rodriguez Marquez 4, Francisca Mulero 1
1CNIO Spanish National Cancer Research Centre Molecular Imaging, C/ Melchor Fernández Almagro,3, 28029 Madrid, Spain
2CNIC, C/ Melchor Fernández Almagro,3, 28029 Madrid, Spain
3CNIO Spanish National Cancer Research Centre Proteomics Unit, C/ Melchor Fernández Almagro,3, 28029 Madrid, Spain
4UAM Universidad Autonoma de Madrid Molecular Biology, Ciudad Universitaria de Cantoblanco, 28049 Madrid, Spain
 
  #PW 23 / 238 Lack of functional normalisation of tumor vessels following anti-angiogenic therapy in glioblastoma
Olivier Keunen 1, Nina Obad 2,3,4, Heidi Espedal 2,4, Radovan Jirik 5, Cecilie Brekke Rygh 6, Georgia Kanli 1, Simone P. Niclou 1,4, Rolf Bjerkvig 1,2,4
1Luxembourg Institute of Health Oncology, 84, Val Fleuri, 1526 Luxembourg, Luxembourg
2University of Bergen Department of Biomedicine, Bergen, Norway
3Haukeland University Hospital Department of Neurosurgery, Bergen, Norway
4University of Bergen KG Jebsen Brain Tumor Research Centre, Bergen, Norway
5Institute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech Republic
6Bergen University College, Bergen, Norway
 
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Room: S-12

PW 24 - Diagnostic and Therapeutic Imaging Strategies in Oncology II
Chair: Frauke Alves & Ralf Bermann
  #PW 24 / 241 In vivo targeting of B cells in lymphoma with biopolymer nanoparticles for theranostic applications.
Sandra Albanese 1,2, Donatella Vecchione 3,4, Luigi Auletta 5, Matteo Gramanzini 6,2, Dario Fiorenza 7, Enza Torino 4, Adelaide Greco 1,2,6
1Univ. degli Studi di Napoli Federico II Dipartimento di Scienze Biomediche Avanzate, Naples, Italy
2CEINGE Biotecnologie Avanzate, scarl, Naples, Italy
3Univ. Degli Studi di Napoli Federico II. Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Napoli, Italy
4Center for Advanced Biomaterials for Health Care, CABHC IIT@CRIB, Naples, Italy
5IRCCS SDN, napoli, Italy
6CNR Istituto di Biostrutture e Bioimmagini, Naples, Italy
7IRCCS SDN, Naples, Italy
 
  #PW 24 / 242 Self-Assembled Oncotheranostic Nano-Complexes
Yunlu Dai 1,2, Ting-Yi Wang 1,2, Thomas Bonnard 3, Jiwei Cui 1,2, Joseph J Richardson 1,2, Christoph Hagemeyer 3, Frank Caruso 1,2, Karen Alt 3
1ARC Centre of Excellence in Convergent Bio-Nano Science and Technology The University of Melbourne, Parkville,, Parkville, Melbourne 3010, Australia
2Department of Chemical and Biomolecular Engineering The University of Melbourne, Parkville, Melbourne 3010, Australia
3Australian Centre for Blood Diseases Faculty of Medicine, Nursing and Health Sciences, Monash University, 99 Commercial Rd, Melbourne 3004, Australia
 
  #PW 24 / 243 Imaging p53 in Pancreatic Ductal Adenocarcinoma (PDAC)
Koustoulidou Sofia, Knight James C., Chua Elvin, Baguña Torres Julia, Kersemans Veerle, O’Neill Eric, Cornelissen Bart
OXFORD, ONCOLOGY - Oxford, United Kingdom
 
  #PW 24 / 244 Binding of αvβ3 integrin-specific radiotracers to cancer cells is modulated by inhibitors of cell signalling pathways
Alexandra Andriu 1, Julie Crockett 2, Sergio Dall'angelo 3, Monica Piras 3, Matteo Zanda 3, Ian Fleming 1
1Aberdeen Biomedical Imaging Centre Institute of Medical Sciences, University of Aberdeen, Foresterhill Road, Aberdeen, United Kingdom, Aberdeen, AB25 2ZD, United Kingdom
2Bone and Musculoskeletal Research Programme Institute of Medical Sciences, University of Aberdeen, Foresterhill Road, Aberdeen, United Kingdom, Aberdeen, AB25 2ZD, United Kingdom
3Kosterlitz Centre for Therapeutics Institute of Medical Sciences, University of Aberdeen, Foresterhill Road, Aberdeen, United Kingdom, Aberdeen, AB25 2ZD, United Kingdom
 
  #PW 24 / 246 18FFDG PET- Lymphography for Identification of Lymph Node Metastases in Murine Melanoma
Hannah Lockau 1,2, Volker Neuschmelting 1,3, Anuja Ogirala 1,4, Antoni Vilaseca Cabo 1, Jan Grimm 1,4
1Memorial Sloan Kettering Cancer Center Dpt of Radiology, New York City, New York United States
2University Hospital of Cologne Dpt of Radiology, Cologne, Germany
3University Hospital of Cologne Dpt of Neurosurgery, Cologne, Germany
4Memorial Sloan Kettering Cancer Center Molecular Pharmacology and Chemistry Program, New York City, New York United States
 
  #PW 24 / 247 Applying transferrin based PET to study oncogene signaling in cancer: Noninvasive measurement of mTORC1 signaling.
Charles Truillet 1,2,3, John T. Cunningham 4, Matthew F.l. Parker 3, Rahul Aggarwal 5,6, Spencer Behr 3, Eric J. Small 5,6, Davide Ruggero 4,5, Jason S. Lewis 7,8, Evans Michael J. 3,5
1Inserm/CEA/Université Paris Sud, UMR 1023 ERL 9218 CNRS, IMIV, 4 pl Gén Leclerc, 91400 ORSAY, France
2CEA DRF/I2BM/SHFJ, 4 pl Gén Leclerc, 91400 ORSAY, France
3UCSF Radiology Department, 185 Berry St, San Francisco, CA 94107, United States
4UCSF Department of Urology, 1600 Divisadero St, San Francisco, CA 94115, United States
5UCSF Helen Diller Family Comprehensive Cancer Center, 1600 Divisadero St, San Francisco, CA 94115, United States
6UCSF Division of Hematology/Oncology, Department of Medicine,, 505 Parnassus Ave, San Francisco, 94143, United States
7Memorial Sloan Kettering Cancer Center Department of Radiology and the Molecular Pharmacology Program, 1275 York Avenue, New York, NY 10065, United States
8Weill Cornell Medical College Departments of Radiology and Pharmacology, 1300 York Ave, New York, NY 10065, United States
 
  #PW 24 / 248 Targeted Radionuclide therapy of Non-Hodgkin lymphoma with 177Lu-radiolabeled anti-hCD20 sdAb
Ahmet Krasniqi 1, Matthias D'huyvetter 1, Catarina Xavier 1, Kevin van der Jeught 2, Serge Muyldermans 3, Tony Lahoutte 1,4, Jan Tavernier 5, Nick Devoogdt 1
1Vrije Universiteit Brussel In Vivo Cellular and Molecular Imaging Laboratory (ICMI), Laarbeeklaan 103 - Building K, 1090 Brussels, Belgium
2Vrije Universiteit Brussel Laboratory of Molecular and Cellular Therapy, Laarbeeklaan 103, 1090 Brussels, Belgium
3Vrije Universiteit Brussel Laboratory of Cellular and Molecular Immunology, 1050 Brussels, Belgium
4Universitair Ziekenhuis Brussel Nuclear Medicine Department, 1090 Brussels, Belgium
5Ghent University Cytokine Receptor Laboratory, 9000 Ghent, Belgium
 
  #PW 24 / 249 The first “in vivo” Fast Field Cycling NMRD profile of tumour tissue in mice. A preliminary study.
Ferrante Gianni1, Geninatti-Crich Simonetta2, Baroni Simona2, Alberti Diego2, Ruggiero Maria Rosaria2, Cutrin Juan Carlos2, Aime Silvio2,2
1STELAR srl - Mede, Italy
2University of Turin, Molecular Biotechnology and Health Sciences - Turin, Italy
 
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Room: S-13

PW 20 - Neuroimaging | Disease Model I
Chair: Andreas Hess & Hervé Boutin
  #PW 20 / 197 Functional connectivity changes following distal middle cerebral artery occlusion in the mouse brain
Minassian Anuka1, Dobrivojevic Radmilovic Marina1, Green Claudia1, Diedenhofen Michael1, Wiedermann Dirk1, Hoehn Mathias1,2,3
1Max Planck Institute for Metabolism Research, In vivo NMR - Cologne, Germany
2Leiden University Medical Center, Radiology - Leiden, Netherlands
3Percuros B.V. - Enschede, Netherlands
 
  #PW 20 / 198 Natriuretic peptide inhibition of bradykinin signaling pathway in acute ischemic stroke
Marina Dobrivojevic Radmilovic 1,2, Katarina Spiranec 2,3, Dunja Gorup 1,2, Igor Erjavec 4, Nikola Habek 2,5, Marin Radmilovic 2, Sanela Unfirer 6, Anita Cosic 7, Ines Drenjancevic 6,7, Srecko Gajovic 1,2, Aleksandra Dugandzic 2,5
1School of Medicine University of Zagreb Department of Histology and Embryology, Šalata 3b, 10000 Zagreb, Croatia
2School of Medicine University of Zagreb Croatian Institute for Brain Research, Šalata 12, 10000 Zagreb, Croatia
3Faculty of Veterinary Medicine, University of Zagreb Department of Anatomy, Histology and Embryology, Zagreb, Croatia
4School of Medicine University of Zagreb Department of Anatomy, Zagreb, Croatia
5School of Medicine University of Zagreb Department of Physiology and Immunology, Zagreb, Croatia
6Faculty of Medicine, University of Osijek Clinical Hospital Center Osijek, Osijek, Croatia
7Faculty of Medicine, University of Osijek Department of Physiology and Immunology, Osijek, Croatia
 
  #PW 20 / 199 Preliminary analysis of multi-parametric PET/MRI in a non-human primate model of cerebral ischemia-reperfusion
Makris Nikolaos1,2, Debatisse Justine2,3, Costes Nicolas2, Langlois Jean-Baptiste2, Villien Marjorie2, Le Bars Didier2, Portier Karine3, Aggour Mohamed3, Rioufol Gilles3, Wiart Marlene3, Ovize Michel3, Wateau Oceane4,5, Contamin Hugues4, Berthezene Yves1, Nighoghossian Norbert1, Vivien Denis5, Barbier Emmanuel L6, Verset Michaël4, Cho Tae-Hee1, Canet-Soulas Emmanuelle3
1CREATIS, Université de Lyon - Lyon, France
2CERMEP-Imagerie du vivant - Bron, France
3CarMeN, Université de Lyon - Lyon, France
4CYNBIOSE - Marcy-l'Etoile, France
5GIP CYCERON - Caen, France
6Institut de Neurosciences - Grenoble, France
 
  #PW 20 / 200 Non-invasive assessment of cerebral perfusion using resting-state functional MRI in a mouse model of focal cerebral ischemia: preliminary results
Ahmed Khalil 1,2,3, Susanne Mueller 4,2, Marco Foddis 2, Ulrich Dirnagl 2, Jochen Fiebach 1, Arno Villringer 3,5, Philipp Boehm-Sturm 4,2
1Charité Universitaetsmedizin Berlin Center for Stroke Research Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
2Charité Universitaetsmedizin Berlin Department of Experimental Neurology, Berlin, Germany
3Max Planck Institute for Human Cognitive and Brain Sciences Department of Neurology, Leipzig, Germany
4Charité Universitaetsmedizin Berlin Charité Core Facility 7 T Experimental MRIs, Berlin, Germany
5Berlin School of Mind & Brain Mind Brain Body Institute, Berlin, Germany
 
  #PW 20 / 201 Functional connectivity during deep brain stimulation in the subthalamic nucleus of hemiparkinson rats measured with FDG-PET
Nadine Apetz 1,2, Elena Kordys 1, Bernd Neumaier 1,3, Alexander Drzezga 4, Lars Timmermann 2,5, Heike Endepols 1,4
1University Hospital of Cologne Institute of Radiochemistry and Experimental Molecular Imaging, Kerpener Str. 62, 50937 Koeln, Germany
2University Hospital of Cologne Neurology, Kerpener Str. 62, 50937 Koeln, Germany
3Forschungszentrum Juelich Institute of Neuroscience and Medicine, INM-5, Wilhelm-Johnen-Straße, 52428 Juelich, Germany
4University Hospital of Cologne Nuclear Medicine, Kerpener Str. 62, 50937 Koeln, Germany
5University Hospital of Marburg Neurology, Baldingerstrasse, 35043 Marburg, Germany
 
  #PW 20 / 202 A decreased response to the NMDAR antagonist MK-801 is shown by pharmacological MRI in a maternal immune activation model
Stephan Missault 1,2, Soumaya Ahmadoun 1, Ines Blockx 2, Disha Shah 2, Annemie van der Linden 2, Marleen Verhoye 2, Stefanie Dedeurwaerdere 1
1Experimental Laboratory of Translational Neuroscience and Otolaryngology Translational Neuroscience, Universiteitsplein 1, 2610 Wilrijk, Belgium
2Bio-Imaging Lab Biomedical Sciences, Universiteitsplein 1, 2610 Wilrijk, Belgium
 
  #PW 20 / 203 Imaging the inwardly rectifying potassium channel Kir4.1 in microglial cell clusters in the spinal cord of an ALS rat model
Perić Mina, Bataveljić Danijela, Andjus Pavle
Center for Laser Microscopy, Faculty of Biology, University of Belgrade - Belgrade, Serbia and Montenegro
 
  #PW 20 / 204 Progressive Amyloid Load in the Brains of Transgenic Alzheimer´s Disease Mice Detected by Florbetaben PET
Antje Willuweit 1, Michael Schöneck 1, Philipp Lohmann 1, Nicole Niemietz 1, Nan Jiang 2, Simone Beer 1, Johannes Ermert 1, Dieter Willbold 2,3, N. Jon Shah 1,4,5, Karl-Josef Langen 1,6
1Forschungszentrum Jülich Institute of Neuroscience and Medicine, 52425 Jülich, Germany
2Forschungszentrum Jülich Institute of Complex Systems, 52425 Jülich, Germany
3Heinrich-Heine-Universität Düsseldorf Institut für Physikalische Biologie, 40225 Düsseldorf, Germany
4RWTH Aachen University Department of Neurology, Pauwelsstraße 30, 52074 Aachen, Germany
5Monash University Department of Electrical and Computer Systems Engineering and Monash Biomedical Imaging, Melbourne Australia
6RWTH Aachen University Hospital Department of Nuclear Medicine, Pauwelsstraße 30, 52074 Aachen, Germany
 
  #PW 20 / 205 Resting state functional MRI (rsfMRI) during early epileptogenesis in the pilocarpine rat model
Martin Meier 1, Heike Breuer 2,3, Pablo Bascuñana Almarcha 2, Marion Bankstahl 3, Ekkehard Küstermann 4, Jens P. Bankstahl 2
1Hannover Medical School, ZTL Preclinical Imaging Labs, Institute for Laboratory Animal Science, Carl-Neuberg-Str.1, 30625 Hannover, Germany
2Hannover Medical School Preclinical Molecular Imaging, Department of Nuclear Medicine, Carl-Neuberg-Str.1, 30625 Hannover, Germany
3University of Veterinary Medicine Hannover and Center for Systems Neuroscience Department of Pharmacology, Toxicology and Pharmacy, Bünteweg 17, 30559 Hannover, Germany
4University of Bremen Department of Chemistry (FB 2), in-vivo MR group, Leobener Str., NW2-C, 28359 Bremen, Germany
 
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Room: S-13

PW 21 - Brain: Structure and Function
Chair: Markus Aswendt & Bertrand Tavitian
  #PW 21 / 206 Manganese-enhanced MRI for the study of post-stroke cognitive impairment in a rodent stroke model
Mohamad El Amki 1, Philipp Baumgartner 1, Oliver Bracko 1, Andreas Luft 1,2, Susanne Wegener 1
1Division of Vascular Neurology and Rehabilitation Department of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland
2cereneo Center for Neurology and Rehabilitation, Vitznau, Switzerland
 
  #PW 21 / 207 First studies of the auditory pathway in gerbils with 18F-FDG PET revealed activations if performed during anesthesia with fentanyl but not if ketamine/xylazine was used
Mariella Kessler 1,2, Martin Mamach 1,2,3, Rainer Beutelmann 4,2, Jens P. Bankstahl 1, Tobias Ross 1, Frank M. Bengel 1, Georg M. Klump 4,2, Georg Berding 1,2
1Hannover Medical School Department of Nuclear Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
2Cluster of Excellence Hearing4All, Hannover, Germany
3Hannover Medical School Department of Medical Physics and Radiation Protection, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
4School of Medicine and Health Sciences, Carl-von Ossietzky University Oldenburg 4Animal Physiology and Behaviour Group, Department for Neuroscience, Oldenburg, Germany
 
  #PW 21 / 208 Persistent Neuropathic Trauma Modulates Functional Connectivity in a Mouse Model of Chronic Nerve Constriction Injury
Katja Sauer 1, Isabel Wank 1, Karl-Heinz Esser 2, Andreas Hess 1
1University of Erlangen-Nuremberg Institute of Pharmacology and Toxicology, Fahrstraße 17, 91054 Erlangen, Germany
2University of Veterinary Medicine Institute of Zoology, Neuroethology, Bünteweg 17, 30559 Hannover, Germany
 
  #PW 21 / 209 Brain atlas of the Mongolian gerbil (Meriones unguiculatus) in CT/MRI-aided stereotaxic coordinates
Susanne Radtke-Schuller 1, Gerd Schuller 1, Frank Angenstein 2, Oliver Grosser 3, Jürgen Goldschmidt 4, Eike Budinger 4
1Ludwig-Maximilians-University Munich Division of Neurobiology II, Munich, Germany
2German Center for Neurodegenerative Diseases within the Helmholtz Association Functional Neuroimaging Group, Magdeburg, Germany
3University Hospital Magdeburg Clinic for Radiology and Nuclear Medicine, Magdeburg, Germany
4Leibniz Institute for Neurobiology Systems Physiology of Learning, Magdeburg, Germany
 
  #PW 21 / 210 Remodeled functional connectivity in the early phase of Alzheimer's pathology in a tauopathy mouse model (Thy-Tau22)
Laetitia Degiorgis 1, Meltem Karatas 1,2, Marion Sourty 1, Chrystelle Po 1, Thomas Bienert 2, Lee Hsu Lei 2, Dominik von Elverfeldt 2, Chantal Mathis 3, Anne-Laurence Boutillier 3, Frédéric Blanc 1,4, Jean-Paul Armspach 1, Laura-Adela Harsan 1,5, Laura-Adela Harsan 1,6
1ICube, Université de Strasbourg-CNRS, Strasbourg, France
2Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany
3Laboratoire de Neurosciences Cognitives et Adaptatives, Université de Strasbourg-CNRS, Strasbourg, France
4Centres Mémoire de Ressources et de Recherche, CHU de Strasbourg, Services Neurologiques et Gériatriques, Strasbourg, France
5Département de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, CHU de Hautepierre, Strasbourg, France
6Département de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, CHU de Hautepierre, Strasbourg, France
 
  #PW 21 / 211 Binge cocaine use induces a persistent local pharmacological modulation of the functional connectivity in the brain.
Elisabeth Jonckers 1, Michaël Belloy 1, Dany D`souza 2, Marleen Verhoye 1, Thomas Mueggler 2, Annemie van der Linden 1
1Bio-Imaging Lab, University of Antwerp Biomedical Sciences, Universiteitsplein 1, 2610 Antwerpen, Belgium
2Translational Neuroscience, CNS Roche, CH, 4070 Basel, Switzerland
 
  #PW 21 / 212 Changes of Sensory and Memory Integration Induced by Recurrent Noxious Events in a Rat Model Demonstrated via fMRI
Isabel Wank , Nicole Motzkus , Silke Kreitz , Andreas Hess
University of Erlangen-Nuremberg Institute of Pharmacology and Toxicology, Fahrstraße 17, 91054 Erlangen, Germany
 
  #PW 21 / 213 Effects of brain development and gender on metabotropic glutamate receptor type 5 availability in rats: A cross-sectional 18F-FPEB PET study
Bart de Laat 1,2, Cindy Casteels 1,2, Koen van Laere 1,2
1University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Leuven, Belgium
2University of Leuven/University Hospital Leuven, Division of Nuclear Medicine, Leuven, Belgium
 
  #PW 21 / 214 Perfusion and metabotropic glutamate receptor subtype 5 are reduced in Factor XII deficient mouse brain
Ni Ruiqing 1,2, Kindler Diana Rita 2, Haider Ahmed 1, Müller Herde Adrienne 3, Rudin Markus 2,4, Klohs Jan 2, Ametamey Simon M. 3
1ETH Zurich Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences - Zurich, Switzerland
2ETH Zurich & University of Zurich Institute for Biomedical Engineering - Zurich, Switzerland
3Center for Radiopharmaceutical Sciences of ETH, PSI and USZ Department of Chemistry and Applied Biosciences of ETH Zurich - Zurich, Switzerland
4University of Zurich Institute of Pharmacology and Toxicology - Zurich, Switzerland
 
  #PW 21 / 215 Low-dose radiation disrupts functional brain connectivity during nociceptive heat stimulation in a mouse model
Silke Kreitz 1,2, Sandra Strobelt 1, Michael Uder 2, Andreas Hess 1
1FAU Erlangen-Nürnberg Institute for Pharmacology and Toxicology, Fahrstraße 17, 91054 Erlangen, Germany
2University Hospital of the FAU Erlangen-Nürnberg Department of Radiology, Maximiliansplatz 1, 91054 Erlangen, Germany
 
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Room: S-13

PW 22 - New Methods in Neuroimaging
Chair: Cornelius Faber & Adrian Rodriguez-Contreras
  #PW 22 / 216 A new graph theoretical multi seed analysis reveals distinctive short-term modulations of resting state connectivity due to whisker stimulation
Silke Kreitz 1,2, Benito de Celis Alonso 3, Michael Uder 2, Andreas Hess 1
1FAU Erlangen-Nürnberg Institute for Pharmacology and Toxicology, Fahrstraße 17, 91054 Erlangen, Germany
2University Hospital of the FAU Erlangen-Nürnberg Department of Radiology, Maximiliansplatz 1, 91054 Erlangen, Germany
3Benemérita Universidad Autónoma de Puebla Faculty of Physics, 4 sur 104 Centro Histórico, 72000 Heroica Puebla de Zaragoza, Mexico
 
  #PW 22 / 217 Multiparametric/-modal imaging of stimulus-evoked neural response in mice and rats
Aileen Schroeter 1, Matthias T. Wyss 2, Charles Quairiaux 3, Felix Schlegel 4, Markus Rudin 4,2
1ETH and University Zurich Institute for Biomedical Engineering, Department for Information Technology and Electrical Engineering, Zurich, Switzerland
2University Zurich Institute of Pharmacology and Toxicology, Zurich, Switzerland
3University Genève Faculty of Medicine, Department of Basic Neurosciences, Genève, Switzerland
4ETH Zurich Institute for Biomedical Engineering, Department for Information Technology and Electrical Engineering, Zurich, Switzerland
 
  #PW 22 / 218 Three-dimensional mouse brain cytoarchitecture revealed by laboratory-based x-ray phase-contrast tomography
Mareike Töpperwien 1, Martin Krenkel 1, Daniel Vincenz 2, Franziska Stöber 2, Anja Oelschlegel 2, Jürgen Goldschmidt 2, Tim Salditt 1
1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany
2Leibniz-Institute for Neurobiology, Brenneckestr. 6, 39118 Magdeburg, Germany
 
  #PW 22 / 219 Time lapse MRI: single cell-tracking in experimental autoimmune encephalomyelitis
Masthoff Max 1, Gran Sandra 2, Zhang Xueli 3, Wachsmuth Lydia 1, Becker Anne 1, Heindel Walter 1, Sorokin Lydia 3, Roth Johannes 2, Eisenblätter Michel 1, Wildgruber Moritz 1, Faber Cornelius 1
1University Hospital of Muenster Tranlational Research Imaging Center, Institute for Clinical Radiology - Muenster, Germany
2University of Muenster Institute for Immunology - Muenster, Germany
3University of Muenster Institute for Physiological Chemistry and Pathobiochemistry - Muenster, Germany
 
  #PW 22 / 220 Hunting another Higgs boson: Symmetry breaking in cerebral pulsation.
Christian Temp Kerskens 1, David López Pérez 1,2
1Trinity College Institute of Neuroscience, College Green, Dublin 2, Ireland
2University of Warsaw Neurocognitive Development Lab and Developmental Psychology Unit, Stawki 5/7, 00-183 Warsaw, Poland
 
  #PW 22 / 221 A molecular insight of the song learning behaviour of Zebra Finch (Taeniopygia guttata) songbirds during ontogeny with mass spectrometry imaging
Ogrinc Potocnik Nina1, Hamaide Julie2, Yadav Garima2, van der Linden Annemie2, Heeren Ron1
1M4I Institute, Maastricht University, Imaging Mass Spectrometry - Maastricht, Netherlands
2University of Antwerp, Bio-Imaging Lab - Wilrijk, Belgium
 
  #PW 22 / 222 Multimodal optical imaging of ultrasound-mediated blood-brain barrier opening to evaluate accumulation of drug delivery systems
Jan-Niklas May 1, Susanne K. Golombek 1, Robert Pola 2, Louis van Bloois 3, Fabian Kiessling 1, Twan Lammers 1
1Uniklinik RWTH Aachen Institute for Experimental Molecular Imaging, Pauwelsstr. 30, 52074 Aachen, Germany
2Academy of Science Institute of Macromolecular Chemistry, Heyrovského nám. 1888/2, 162 00 Prague, Czech Republic
3Utrecht University Utrecht Institute for Pharmaceutic Sciences, Universiteitsweg 99, 3584 Utrecht, Netherlands
 
  #PW 22 / 223 Measurement of dopamine release in a transgenic mouse model using [11C]raclopride positron emission tomography
Anna Lena Cremer 1, Rachel Lippert 2, Heiko Backes 1
1Max Planck Institute for Metabolism Research Multimodal Imaging of Brain Metabolism, Gleueler Straße 50, 50931 Cologne, Germany
2Max Planck Institute for Metabolism Research Neuronal Control of Brain Metabolism, Gleueler Straße 50, 50931 Cologne, Germany
 
  #PW 22 / 224 High throughput three-dimensional imaging of myelin fibers in the whole mouse brain
Hugo Rositi 1, Violaine Hubert 2, Loriane Weber 1, Elodie Ong 2, Lise-Prune Berner 1, Carole Frindel 1, David Rousseau 1, Cécile Olivier 1, Max Langer 1, Tae-Hee Cho 1, Norbert Nighoghossian 1, Yves Berthezene 1, Françoise Peyrin 1, Fabien Chauveau 3, Marlene Wiart 2
1Univ-Lyon, CREATIS laboratory, CNRS UMR 5220, INSERM U1044, Université Claude Bernard Lyon 1, INSA Lyon, Lyon, France
2Univ-Lyon, CarMeN laboratory, Inserm U1060, INRA U1397, Université Claude Bernard Lyon 1, INSA Lyon, Charles Mérieux Medical School, Lyon, France
3Univ-Lyon, Lyon Neuroscience Research Center, CNRS UMR5292, Inserm U1028, Université Claude Bernard Lyon 1, Lyon, France
 
  #PW 22 / 225 A Simultaneous PET/fMRI Protocol to Quantify Molecular and Functional Changes in a Rat Model of Parkinson’s Disease
Laura Kuebler 1, Kristina Herfert 1, Natalie Landeck 2, Andreas Maurer 1, Mario Amend 1, André Thielcke 1, Sabrina Buss 1, Sabina Marciano 1, Ramona Stumm 1, Hans F. Wehrl 1, Deniz Kirik 2, Bernd J. Pichler 1
1Werner Siemens Imaging Center Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls Universtiy, Tuebingen, Germany
2Brain Repair and Imaging in Neural Systems (BRAINS) Unit Department of Experimental Medical Science, Lund University, Lund, Sweden
 
  #PW 22 / 226 fMRI in awake rats reveals that exposure to familiar and novel stimuli yields hippocampal BOLD responses for opposite contrasts depending on the duration of the habituation to the stimuli
Chwiesko Caroline 1, Boulat Benoit 1, Wiedermann Dirk 2, Hoehn Mathias 2, Sauvage Magdalena 3,4,1
1Ruhr University Bochum Mercator Research Group - Bochum, Germany
2Max-Planck Insitute Neurological Research - Köln, Germany
3Leibniz-Insititute for Neurobiology Functial Architecture of Memory - Magdeburg, Germany
4Otto-von-Guericke University Medical Faculty - Magdeburg, Germany
 


 

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