Effect of anti-CCL2-mediated vascular normalization on the tumor accumulation of nanomedicines (#584) Maike Baues 1, Diana Möckel 1, Josef Ehling 1, Matthias Bartneck 2, Frank Tacke 2, Fabian Kiessling 1, Twan Lammers 1 1RWTH Aachen University Institute for Experimental Molecular Imaging (ExMI), Pauwelsstrasse 30, 52074 Aachen, Germany 2RWTH Aachen University Medicine III, Pauwelsstrasse 30, 52074 Aachen, Germany
13:36
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Priming tumor blood vessels and the tumor microenvironment to improve nanomedicine-mediated drug delivery (#538) Tarun Ojha, Josef Ehling, Paolo Ceccarini, Diana Möckel, Fabian Kiessling, Twan Lammers
University Clinic-RWTH - Aachen University Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Pauwelsstrasse 30, 52074 Aachen, Germany
13:42
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Preclinical pharmacodynamics of anti-FAP-IL2v immunotherapy with [68Ga]DOTA-Siglec-9 in B16-FAP-melanoma mice (#409) Riikka Siitonen 1, Helena Virtanen 1, Heidi Liljenbäck 1,2, Olli Metsälä 1, Marika Karikoski 3, Pia Rantakari 3, Christian Klein 4, Tapan Nayak 4, Sirpa Jalkanen 3, Anne Roivainen 1,2 1Turku PET Centre, University of Turku & Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland 2Turku Center for Disease Modeling, University of Turku, Turku, Finland 3MediCity Research Laboratory, University of Turku, Turku, Finland 4F. Hoffmann-La Roche Ltd, Basel, Switzerland
13:48
#SG 02 / 4
Insights into the effect of size on tumor uptake and distribution of nanobodies through dual‐isotope SPECT imaging (#196)
Rene Rompen 1, Raffaella Rossin 2, Klaas Nicolay 1, Paul van Bergen En Henegouwen 3, Holger Grüll 1,2, Sabrina Oliveira 3 1Eindhoven University of Technology Biomedical Engineering, De Zaale, 5612 AJ Eindhoven, Netherlands 2Philips Research Laboratories Minimally Invasive Healthcare, High Tech Campus 34, 5656 AE Eindhoven, Netherlands 3Utrecht University Biology, Padualaan 8, 3584CH Utrecht, Netherlands
13:54
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Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases and brain tumors: from bench to beside. (#112) Lucie Sancey 1, Shady Kotb 1, Sandrine Dufort 2, Francois Lux 1, Camille Verry 3, Géraldine Le Duc 2, Olivier Tillement 1 1Institut Lumière Matière, UMR5306 Univ. Lyon 1-CNRS Team FENNEC, 2 rue V. Grignard, 69622 Villeurbanne, France 2NH Theraguix Atrium, 69622 Villeurbanne, France 3CHU Grenoble Radiotherapy Department, 38041 Grenoble, France
14:00
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Trivalent FAP/HER2/Edg-targeted activatable immunoliposomes for in vivo fluorescence imaging of a broad spectrum of tumors (#169) Felista L. Tansi 1, Ronny Rüger 2, Frank Steiniger 3, Roland E. Kontermann 4, Ulf Teichgräber 1, Alfred Fahr 2, Ingrid Hilger 1 1Jena University Hospital IDIR-Experimental Radiology, Erlangerallee 101, 07747 Jena, Germany 2Friedrich-Schiller University Jena Dept. of Pharmaceutical Technology (PHT), Lessingstr. 8, 07743 Jena, Germany 3Jena University Hospital Center for Electron Microscopy, Ziegelmuehlenweg 1, 07743 Jena, Germany 4University Stuttgart Institute of Cell Biology and Immunology, Allmandring 31, 70569 Stuttgart, Germany
14:06
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Radiofluorinated PET Imaging based on the PARP1 inhibitor Olaparib (#12) Brandon Carney 1,2, Giuseppe Carlucci 1, Susanne Kossatz 1, Beatriz Salinas 1, Wolfgang Weber 1,3,4, Thomas Reiner 1,4 1Memorial Sloan Kettering Cancer Center Radiology, 68th Street, New York, New York 10065, United States 2Hunter College and Graduate Center of the City University of New York Chemistry, 695 Park Ave, New York, New York 10065, United States 3Memorial Sloan Kettering Cancer Center Program in Molecular Pharmacology, 68th Street, New York, New York 10065, United States 4Weill Cornell Medical College Radiology, York Ave, New York, New York 10065, United States
14:12
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Photopharmacology: light-controlled therapy for theranostics (#296) Wiktor Szymanski 1,2, Ben L. Feringa 2 1University Medical Center Groningen Department of Radiology, Hanzeplein 1, 9713GZ Groningen, Netherlands 2University of Groningen Stratingh Institute, Nijenborgh 7, 8747AG Groningen, Netherlands
14:18
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Assessment of Doxorubicin Penetration in the Tumor Microenvironment after Release from Thermosensitive Liposomes during Mild Hyperthermia (#254) Marc Derieppe 1, Baudouin Denis de Senneville 1,2, Jean-Michel Escoffre 1, Quincy van Houtum 1, Angelique Barten 1, Clemens Bos 1, Chrit Moonen 1 1University Medical Center Utrecht Imaging Division, Heidelberglaan 100 P.O. Box 85500, Utrecht, Netherlands 2UMR 5251, CNRS, Université de Bordeaux Institut de Mathématiques de Bordeaux, 351, cours de la Libération, F33405 Talence, France
14:24
#SG 02 / 10
Hybrid-PET/MRI imaging: Orthotopic tumors show different tumor tissue characteristics than subcutaneously grown tumors (#556) Eva Jolanthe Koziolek 1, Jakob Albrecht 1, Sarah Erdmann 2, Dietrich Polenz 3, Samantha Exner 2, Leder Annemarie 3, Nicola Beindorff 1, Winfried Brenner 1 1Charite Berlin Berlin Experimental Radionuclide Imaging Center, Augustenburger Platz 1, 13535 Berlin, Germany 2Charite Berlin Department of Hepatology and Gastroenterology, Molecular Cancer Research Center, Augustenburger Platz 1, 13535 Berlin, Germany 3Charite Berlin General, Visceral, and Transplantation Surgery Experimental Surgery and Regenerative Medicine, Augustenburger Platz 1, 13535 Berlin, Germany
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