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EMIM 2016 - Session Details

PO 01 | Poster Session 01
Type: Poster Session
Date: March 09, 2016
Time: 9:30 - 11:15
Poster walks:
top PW 01 - Cardiovascular Imaging
Chair: Willem Mulder, Frank Bengel
  #1 Exploration of Glucose Metabolism and Vascular Function of Anti-angiogenic Related Cardiotoxicity by Multimodality Imaging
Joevin Sourdon 1,2, Thomas Viel 1,2, Daniel Balvay 1,2, Franck Lager 3,2, Gilles Renault 3,2, Bertrand Tavitian 1,2,4
1INSERM U970 Paris-Cardiovascular Research Center, 56 rue leblanc, 75015 Paris, France
2Paris Descartes University, 12 rue de l'école de medecine, 75018 Paris, France
3INSERM U1016 Institut Cochin, 75014 Paris, France
4Hôpital Européen Georges Pompidou Service de radiologie, 56 rue leblanc, 75015 Paris, France
 
  #2 Automatic classification of hemodynamic significant stenosis from dynamic CT myocardial perfusion with CTA based myocardial territories
Marco Giordano 1,2, Dirk Poot 1,2, Adriaan Coenen 3, Koen Nieman 3, Theo van Walsum 2, Wiro Niessen 2,1
1TU Delft Department of Imaging Physics, Lorentzweg 1, 2628CJ Delft, Netherlands
2Erasmus MC Biomedical Imaging Group Rotterdam, 's Gravendijkwal 230, 3015 CE Rotterdam, Netherlands
3Erasmus MC Department of Cardiology and Radiology, 's Gravendijkwal 230, 3015CE Rotterdam, Netherlands
 
  #3 NON-INVASIVE IMAGING OF LUNG REMODELING AND RIGHT VENTRICLE METABOLISM SHIFT IN AN ANIMAL MODEL OF PULMONARY ARTERIAL HYPERTENSION
Arias Teresa, Mateo Jesús, España Samuel, Ruiz-Cabello Jesús
National Centre for Cardiovascular Research (CNIC) Advanced Imaging Unit - Madrid, Spain
 
  #4 Hyperpolarized 13C-butyric acid for fatty-acids metabolic studies in vivo
Alessandra Flori 1, Giulio Giovannetti 2,3, Silvia Burchielli 2, Maria Filomena Santarelli 2,3, Vincenzo Positano 2, Francesca Frijia 1, Daniele de Marchi 2, Luigi Landini 1,4, Giovanni Donato Aquaro 2, Luca Menichetti 2,3
1. Fondazione CNR/Regione Toscana G.Monasterio Bioengineering & Clinical Engineering Unit, via G. Moruzzi, 1, 56124 Pisa, Italy
2Fondazione CNR/Regione Toscana G.Monasterio, via G. Moruzzi, 1, 56124 Pisa, Italy
3National Research Council (CNR) Institute of Clinical Physiology, via G. Moruzzi, 1, 56124 Pisa, Italy
4University of Pisa Department of Information Engineering, Pisa, Italy
 
  #5 Evaluation of the relationship between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy using I-123 BMIPP
Kentaro Takanami , Rei Umezawa , Kei Takase
Tohoku University Hospital Department of Radiology, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan
 
  #6 Evaluation of myocardial blood flow in patients with myocardial bridging: A 13N-ammonia PET study.
Monroy-Gonzalez Andrea De G.1, Berríos-Bárcenas Enrique A.2, Juarez-Orozco Luis E.1, González-Padilla Christian2, Meave-González Aloha3, Tio Rene1, Alexanderson-Rosas Erick2,4, Slart Riemer1,5
1University Medical Center Groningen,, Department of Nuclear Medicine and Molecular Imaging - Groningen, Netherlands
2National Institute of Cardiology Ignacio Chavez, Nuclear Cardiology - Mexico, Mexico
3National Institute of Cardiology Ignacio Chavez, Magnetic Resonance - Mexico, Monaco
4National Autonomous University of Mexico, PET/CT Unit - Mexico, Mexico
5University of Twente, Faculty of Science and TechnologyBiomedical Photonic Imaging - Twente, Netherlands
 
  #7 DIAGNOSTIC VALUE OF MYOCARDIAL BLOOD FLOW MEASURED BY POSITRON EMISSION TOMOGRAPHY IN CORONARY ARTERY DISEASE
Monroy Gonzalez Andrea De G.1, Berríos-Bárcenas Enrique A.2, Juarez-Orozco Luis E.1, González-Padilla Christian2, Meave-González Aloha3, Tio Rene1, Slart Riemer1,4, Alexanderson-Rosas Erick2
1University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging - Groningen, Netherlands
2National Institute of Cardiology Ignacio Chavez, Nuclear Cardiology - Mexico, Mexico
3National Institute of Cardiology Ignacio Chavez, Magnetic Resonance - Mexico, Mexico
4University of Twente, Faculty of Science and TechnologyBiomedical Photonic Imaging - Twente, Netherlands
 
  #8 Assessment of Myocardial Perfusion and Extracellular Volume Fraction using 68Ga-DOTA PET
Samuel España 1,2, Teresa Arias 1,2, Carlos Velasco 1,2, Juan Pellico 1,2, Fernando Herranz 1,2, Jesús Ruiz-Cabello 1,2, Jesús Mateo 1,2
1Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Advanced Imaging Unit, C/Melchor Fernández Almagro, 28029 Madrid, Spain
2CIBER de Enfermedades Respiratorias (CIBERES), C/Melchor Fernández Almagro, 28029 Madrid, Spain
 
  #9 Photoacoustic Cardiovascular Imaging: Adding New Dimensions for Functional Assessment of Myocardial Infarction
Philippe Trochet 1, Dieter Fuchs 1, Andrew Heinmiller 2, Alex Forbrich 2, Andrew Needles 2, Jithin Jose 1
1FUJIFILM VisualSonics, Joop Geesinkweg 140, 1114AB Amsterdam, Netherlands
2FUJIFILM VisualSonics, 3080 Yonge Street, Toronto M4N 3N1, Canada
 
  #10 Gender differences in absolute myocardial blood flow with 13N-ammonia PET in patients with known or suspected CAD
Luis Eduardo Juárez-Orozco 1,2, Erick Alexanderson-Rosas 3,2, Rudi Dierckx 4, Rene Tio 5, Riemer Slart 6,7
1PhD Student Nuclear Medicine and Molecular Imaging, UMCG, Hanzeplein 1, Internal postcode EB50, 9700RB Groningen, Netherlands
2PET/CT Unit Medical Faculty, UNAM, Mexico City, Mexico
3Chair Nuclear Cardiology National Heart Institute, Mexico City, Mexico
4Chair Nuclear Medicine and Molecular Imaging, UMCG, Groningen, Netherlands
5As.Prof. Cardiology, UMCG, Groningen, Netherlands
6. Nuclear Medicine and Molecular Imaging, UMCG, Groningen, Netherlands
7. BMPI, University of Twente, Enschede, Netherlands
 
  #11 Myocardial infarction assessment with 23Na MR in isolated pig hearts
Alessandra Flori 1, Giulio Giovannetti 2,3, Daniele de Marchi 2, Giorgio Virgili 4, Giovanni Donato Aquaro 2, Alessandro Pingitore 3
1. Fondazione CNR/Regione Toscana G.Monasterio Bioengineering & Clinical Engineering Unit, via G. Moruzzi, 1, 56124 Pisa, Italy
2Fondazione CNR/Regione Toscana G.Monasterio, via G. Moruzzi, 1, 56124 Pisa, Italy
3National Research Council (CNR) Institute of Clinical Physiology, via G. Moruzzi, 1, 56124 Pisa, Italy
4West Systems s.r.l., Viale Donato Giannotti 24, 56126 Florence, Italy
 
  #12 Femoral artery cuff implantation: a new model of peripheral shear stress induced atherosclerosis
Sarah Eligehausen 1, Michael Kuhlmann 1, Sven Hermann 1, Michael Schäfers 1,2
1University of Muenster European Institute for Molecular Imaging, Waldeyerstr. 15, 48149 Münster, Germany
2University Hospital Muenster Department of Nuclear Medicine, Domagkstr. 5, 48149 Münster, Germany
 
  #13 Quantitative in vivo Streamline Analysis of Cardiac Flow using 4D PC MRI
Bovenkamp Philipp 1, Brix Tobias 2, Scherzinger Aaron 2, Hinrichs Klaus 2, Hoerr Verena 3,1
1University Hospital Münster Department of Clinical Radiology - Münster, Germany
2University of Münster Department of Computer Science - Münster, Germany
3Jena University Hospital Istitute of Medical Microbiology - Jena, Germany
 
top PW 02 - New PET & SPECT Probes
Chair: Nick Devoogdt, Paul Lecoq
  #38 Radiolabelling and in-vivo SPECT biodistribution study of liposomes using a novel iminothiolane-99mTc-tricarbonyl complex
Varga Zoltan 1, Istvan Gyurko 2,1, Imola Szigyarto 1, Doczi Rita 2, Horvath Ildiko 3, Mathe Domokos 4, Szigeti Krisztian 3
1Research Centre for Natural Sciences Biological Nanochemistry Research Group, Institute of Materials and Environmental Chemistry, Budapest, Hungary
2Budapest University of Technology and Economics Institute of Nuclear Techniques, Budapest, Hungary
3Semmelweis University Department of Biophysics and Radiation Biology, Budapest, Hungary
4CROmed Research and Service Centers Ltd., Budapest, Hungary
 
  #40 Synthesis and preclinical characterization of 1´-β-D-6´-Deoxy-6´-[18F]fluoroallofuranosyl-2-nitroimidazole (β-[18F]FAZAL) as radiotracer to assess tumor hypoxia with positron emission tomography
Thomas Wanek 1, Katharina Kreis 1, Christoph Denk 2, Johann Stanek 1, Severin Mairinger 1, Thomas Filip 1, Michael Sauberer 1, Friedrich Hammerschmidt 3, Hans-Jürgen MacHulla 4, Oliver Langer 1,5, Claudia Kuntner 1
1AIT Austrian Institute of Technology Biomedical Systems, -none-, 2444 Seibersdorf, Austria
2Vienna University of Technology Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163, 1060 Vienna, Austria
3University of Vienna Institute of Organic Chemistry, Währingerstraße 38,, 1090 Vienna, Austria
4Eberhard Karls Universität Tübingen Institute for Radiopharmacy, Ziegelhüttestraße 46, 72072 Tübingen, Germany
5Medical University of Vienna Department of Clinical Pharmacology, Währinger Gürtel 18-20, 1090 Vienna, Austria
 
  #42 Imaging P-gp function at the BBB: Synthesis and evaluation of new fluorine-18 labelled verapamil analogues
Renske M. Raaphorst 1, Gert Luurtsema 2, Robert C. Schuit 1, Esther J. M. Kooijman 1, Adriaan A. Lammertsma 1, Philip H. Elsinga 2, Albert D. Windhorst 1
1VU University Medical Center Dept. of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, Amsterdam, Netherlands
2University Medical Center Groningen, University of Groningen Dept. of Nuclear Medicine and Molecular Imaging, Groningen, Netherlands
 
  #43 Ga-67: reassessment as a theranostic partner for Ga-68
Samantha Terry , Muhamad Bin Othman , Mitry Nabil , Philip Blower
King’s College London Department of Imaging Chemistry and Biology, London, United Kingdom
 
  #44 Insights into the effect of size on tumor uptake and distribution of nanobodies through dual‐isotope SPECT imaging
Rene Rompen 1, Raffaella Rossin 2, Klaas Nicolay 1, Paul van Bergen En Henegouwen 3, Holger Grüll 1,2, Sabrina Oliveira 3
1Eindhoven University of Technology Biomedical Engineering, De Zaale, 5612 AJ Eindhoven, Netherlands
2Philips Research Laboratories Minimally Invasive Healthcare, High Tech Campus 34, 5656 AE Eindhoven, Netherlands
3Utrecht University Biology, Padualaan 8, 3584CH Utrecht, Netherlands
 
  #46 Radiofluorinated PET Imaging based on the PARP1 inhibitor Olaparib
Brandon Carney 1,2, Giuseppe Carlucci 1, Susanne Kossatz 1, Beatriz Salinas 1, Wolfgang Weber 1,3,4, Thomas Reiner 1,4
1Memorial Sloan Kettering Cancer Center Radiology, 68th Street, New York, New York 10065, United States
2Hunter College and Graduate Center of the City University of New York Chemistry, 695 Park Ave, New York, New York 10065, United States
3Memorial Sloan Kettering Cancer Center Program in Molecular Pharmacology, 68th Street, New York, New York 10065, United States
4Weill Cornell Medical College Radiology, York Ave, New York, New York 10065, United States
 
  #47 The use of 152Tb in preclinical investigations: its mass separation and subsequent application for imaging
Nicholas van der Meulen 1,2, Christiaan Vermeulen 1, Ulli Koester 3, Karl Johnston 4, Roger Schibli 1,5, Andreas Tuerler 2,6, Cristina Mueller 1
1Paul Scherrer Institute Center for Radiopharmaceutical Sciences, 5232 Villigen, Switzerland
2Paul Scherrer Institute Laboratory for Radiochemistry and Environmental Chemistry, 5232 Villigen, Switzerland
3Institut Laue-Langevin, 38042 Grenoble, France
4CERN ISOLDE, Geneva, Switzerland
5ETH Zurich Department of Chemistry and Applied Biosciences, 8092 Zurich, Switzerland
6University of Bern Department of Chemistry and Biochemistry, Bern, Switzerland
 
  #48 Synthesis and preclinical evaluation of carbon-11 labelled P2X7 receptor antagonists as PET tracers of microglial activation
Bieneke Janssen 1, Shane M. Wilkinson 2, Dieter Ory 3, Danielle J. Vugts 1, Robert C. Schuit 1, Esther J. M. Kooijman 1, Ger T. Molenaar 4,1, Uta Funke 4,1, Perry S. Kruijer 4, Adriaan A. Lammertsma 1, Guy Bormans 3, Michael Kassiou 2,5,6, Albert D. Windhorst 1
1VU University Medical Center Radiology & Nuclear Medicine, De Boelelaan 1085c, 1081 HV Amsterdam, Netherlands
2University of Sydney School of Chemistry, Sydney Australia
3KU Leuven Laboratory for Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium
4BV Cyclotron VU, Amsterdam, Netherlands
5Brain and Mind Research Institute, Sydney Australia
6University of Sydney Discipline of Medical Radiation Sciences, Sydney Australia
 
  #49 Synthesis and Comparison of Several Small Molecules as Novel PET Tracers for In Vivo Imaging of Tumor Senescence
Jonathan Cotton 1, Anna Kuehn 1, Andreas Maurer 1, Kerstin Fuchs 1, Katharina Wolter 2, Klaus Schulze-Osthoff 3, Lars Zender 2, Bernd J. Pichler 1
1Werner Siemens Imaging Center Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tuebingen, Germany, Röntgenweg 13, Tuebingen, Germany
2Division of Molecular Oncology of Solid Tumors Department of Internal Medicine, University Hospital Tuebingen, Germany, Tuebingen, Germany
3Interfaculty Institute of Biochemistry Eberhard Karls University of Tuebingen, Germany, Tuebingen, Germany
 
  #50 Efficient synthesis of [11C]glutamine.
Filp Ulrike1, Pees Anna1, Taddei Carlotta2, Pekosak Aleksandra1, Gee Antony2, Poot Alex1, Windhorst Albert D.1
1Radiology & Nuclear Medicine, VUmc, Radionuclide Center - Amsterdam, Netherlands
2Division of Imaging Sciences and Biomedical Engineering, King’s College London - London, United Kingdom
 
  #51 A new radiotracer for PET imaging of the activin receptor-like kinase 5
Lonneke Rotteveel 1, Uta Funke 1, Peter ten Dijke 2, Harm Jan Bogaard 1, Adriaan A. Lammertsma 1, Albert D. Windhorst 1
1VU University Medical Center Radiology & Nuclear medicine, De Boelelaan VU 1085c, 1081 HV Amsterdam, Netherlands
2Leiden University Medical Center Molecular Cell Biology, Einthovenweg 20, 2333 ZC Leiden, Netherlands
 
  #52 In vivo evaluation of a novel 18F-labeled cyclooxygenase-2 inhibitor based on a tricyclic core structure by small animal PET
Christin Neuber 1, Markus Laube 1, Cemena Gassner 1,2, Ralf Bergmann 1, Torsten Kniess 1, Jens Pietzsch 1,2
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research Radiopharmaceutical and Chemical Biology, Bautzner Landstaße 400, 01328 Dresden, Germany
2Technische Universität Dresden Department of Chemistry and Food Chemistry, Dresden, Germany
 
  #53 Synthesis of [11C]vemurafenib via an [11C]CO carbonylative Stille coupling to image V600E mutated B-Raf expression in cancer
Slobbe Paul, Windhorst Albert D., Dongen Guus Van, Poot Alex
VU University Medical Center, Radiology and Nuclear Medicine - Amsterdam, Netherlands
 
  #54 Evaluation of new benzoxazole-based radioligands as alpha-synuclein radiotracers
Mathieu Verdurand 1, Elise Levigoureux 1, Waël Zeinyeh 2, Florence Cadarossanesaib 3, Caroline Bouillot 3, Luc Zimmer 1,3, Sophie Lancelot 1, Thierry Billard 2,3, Fabien Chauveau 1
1University of Lyon, Lyon Neuroscience Research Center (CRNL); CNRS UMR5292; INSERM U1028; Univ. Lyon 1, Lyon, France
2University of Lyon, Institute of Chemistry and Biochemistry (ICBMS); CNRS UMR5246, Lyon, France
3CERMEP-Imagerie du Vivant, Lyon, France
 
  #55 Development of A PET tracer to study THE liver transporter OATP1B1 (SLCO1B1)Development of A PET tracer to study THE liver transporter OATP1B1 (SLCO1B1)
Matteo Zanda 1, Andrea Testa 1, Dall'angelo Sergio 1, Marco Mingarelli 1, Andrea Augello 1, Lutz Schweiger 1, Pradeep Sharma 2, Chad S Elmore 3
1University of Aberdeen IMS, Foresterhill, Aberdeen, AB252ZD, United Kingdom
2AstraZeneca R&D, Cambridge, CB4 0WG, United Kingdom
3AstraZeneca R&D, Pepparedsleden 1, 43150 Mölndal, Sweden
 
  #57 Novel multimodal imaging agent for stem cell tracking
May Zaw-Thin 1, Robin Bofinger 2, John Connell 1, Stephen Patrick 1, Helen Hailes 2, Alethea Tabor 2, Mark Lythgoe 1, Tammy Kalber 1
1University College London Centre for Advanced Biomedical Imaging, 72 Huntley Street, London, WC1E 6DD, United Kingdom
2University College London Department of Chemistry, 20 Gordon Street, London, WC1H 0AJ, United Kingdom
 
  #58 Core-doped 68Ga-Fe2O3 for the in vivo detection of neutrophils
Pellico Juan 1,2, Lechuga-Vieco Ana V. 1,2, Ruiz-Cabello Jesús 1,2,3, Herranz Fernando 1,2
1Centro Nacional de Investigaciones Cardiovasculares Advanced Imaging Unit - Madrid, Spain
2CIBERES - Madrid, Spain
3Universidad Complutense de Madrid Physicochemistry II - Madrid, Spain
 
  #59 In vivo characterisation of a novel tracer for PET imaging of PARP-1
Filip Zmuda 1, Gaurav Malviya 2, Adele Blair 3, Andrew Sutherland 3, Anthony Chalmers 4, Sally Pimlott 5,1
1University of Glasgow School of Medicine, Glasgow, G12 8QQ, United Kingdom
2Cancer Research UK Beatson Institute Nuclear Imaging, Glasgow, G61 1BD, United Kingdom
3University of Glasgow School of Chemistry, Glasgow, G12 8QQ, United Kingdom
4University of Glasgow Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Glasgow, G61 1QH, United Kingdom
5Greater Glasgow and Clyde NHS Trust West of Scotland PET Centre, Gartnavel General Hospital, Glasgow, G12 0YN, United Kingdom
 
top PW 03 - New US & Optical Probes
Chair: Twan Lammers, Klazina Koiiman
  #60 Engineering Gold Nanomaterials with Near-Infrared Absorption for Optoacoustic Imaging and Photothermal Therapy in for the Treatment of Cancer.
Stephen Evans , Kevin Critchley
University of Leeds Physics and Astronomy, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
 
  #61 Trivalent FAP/HER2/Edg-targeted activatable immunoliposomes for in vivo fluorescence imaging of a broad spectrum of tumors
Felista L. Tansi 1, Ronny Rüger 2, Frank Steiniger 3, Roland E. Kontermann 4, Ulf Teichgräber 1, Alfred Fahr 2, Ingrid Hilger 1
1Jena University Hospital IDIR-Experimental Radiology, Erlangerallee 101, 07747 Jena, Germany
2Friedrich-Schiller University Jena Dept. of Pharmaceutical Technology (PHT), Lessingstr. 8, 07743 Jena, Germany
3Jena University Hospital Center for Electron Microscopy, Ziegelmuehlenweg 1, 07743 Jena, Germany
4University Stuttgart Institute of Cell Biology and Immunology, Allmandring 31, 70569 Stuttgart, Germany
 
  #62 Red-emitting Fluorescent Activatable Probes for the Detection of Reactive Oxygen Species.
Garcia Guzman Claudia, Vendrell Marc, Bradley Mark
UNIVERSITY OF EDINBURGH, SCHOOL OF CHEMISTRY - EDINBURGH, United Kingdom
 
  #63 A novel tumor-specific agent targeting the folate receptor-alpha for intraoperative near-infrared fluorescence imaging: a translational study in healthy volunteers and patients with ovarian cancer
Charlotte Hoogstins 1,2, Quirijn Tummers 1,2, Katja Gaarenstroom 3, Cor de Kroon 3, Baptist Trimbos 3, Tjalling Bosse 4, Vincent Smit 4, Jaap Vuyk 5, Cornelis van de Velde 1, Adam Cohen 2, Philip Low 6, Jacobus Burggraaf 2, Alexander Vahrmeijer 1
1Leiden University Medical Center Surgery, Albinusdreef 2, 2333ZA Leiden, Netherlands
2Centre for Human Drug Research, Zernikedreef 8, 2333CL Leiden, Netherlands
3Leiden University Medical Center Gynaecology, Albinusdreef 2, 2333ZA Leiden, Netherlands
4Leiden University Medical Center Pathology, Albinusdreef 2, 2333ZA Leiden, Netherlands
5Leiden University Medical Center Anesthesiology, Albinusdreef 2, 2333ZA Leiden, Netherlands
6Purdue University Chemistry, 575 W Stadium Ave, West-Lafayette, Indiana IN47907, United States
 
  #64 Responsive dyes for live cell imaging: a novel series of pH-sensitive cyanine dyes
Virginia Wycisk 1, Katharina Achazi 1, Rainer Haag 1, Kai Licha 2
1Freie Universität Berlin Department of Biology, Chemistry, Pharmacy, Takustrasse 3, 14195 Berlin, Germany
2IC Discovery GmbH, Robert-Koch-Platz 4, 10115 Berlin, Germany
 
  #65 CdTe Quantum Dots – Transferrin Bioconjugates as Fluorescent Probes for Glioblastoma Cells
Paulo E. Cabral Filho 1, Ana P. M. Ramos 1, Ana L. C. Cardoso 2, Maria I. A. Pereira 1, Giovannia A. L. Pereira 3, Fernando Hallwass 3, M. Margarida C.a. Castro 4, Carlos F. G. C. Geraldes 4, Maria C. Pedroso de Lima 2, Beate S. Santos 5, Adriana Fontes 1
1Federal University of Pernambuco Biophysics and Radiobiology Dept, Recife, Pernambuco, Brazil
2University of Coimbra Center for Neuroscience and Cell Biology, Coimbra, Portugal
3Federal University of Pernambuco Dept of Fundamental Chemistry, Recife, Pernambuco, Brazil
4University of Coimbra Dept of Life Sciences and Coimbra Chemistry Center, Faculty of Science and Technology, Coimbra, Portugal
5Federal University of Pernambuco Dept of Pharmaceutical Sciences, Recife, Brazil
 
  #66 Photoacoustic imaging of novel hollow silica nanoparticles
Cinzia Avigo 1, Valerio Voliani 2, Domenico Cassano 2,3, Claudia Kusmic 1, Paolo Armanetti 4, Nicole di Lascio 5,1, Francesco Faita 1, Giovanni Signore 2, Vincenzo Piazza 2, Luca Menichetti 1,6
1Institute of Clinical Physiology National Research Council, G. Moruzzi, 1, 56124 Pisa, Italy
2Center for Nanotechnology Innovation@NEST Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, 56127 Pisa, Italy
3NEST-Scuola Normale Superiore, Pisa, Italy
4Department of Physics “E. Fermi” University of Pisa, Largo Bruno Pontecorvo, 3, 56127 Pisa, Italy
5Scuola Superiore Sant'Anna, Piazza Martiri della Libertà, 33, 56127 Pisa, Italy
6Fondazione CNR/Regione Toscana G.Monasterio, via G. Moruzzi, 1, 56124 Pisa, Italy
 
  #67 In vitro characterization of a new optical imaging probe targeting αvβ3 integrin
Federica Chianale , Chiara Brioschi , Mariapaola Bartolomeo , Federico Crivellin , Matteo Beretta , Giovanni Valbusa , Federico Maisano , Fabio Tedoldi
Bracco Imaging S.p.A CRB, Centro Ricerche Bracco, via Ribes 5, 10010 Colleretto Giacosa, Italy
 
  #68 Theranostic nanovectors for early diagnosis and therapy of cancer
Jungyoon Choi 1, Tao Jia 1, Jéremmie Ciccione 2, Emilie Roustique 3, Maxime Henry 1, Muriel Amblard 2, Jérome Boutet 3, Ahmad Mehdi 2, Jean Martinez 2, Gilles Subra 2, Jean-Luc Coll 1
1CRI INSERM-UJF U823, Institut Albert Bonniot, Grenoble, France
2UMR5247 CNRS IBMM, Grenoble, France
3CEA Grenoble, LETI-DTBS, Grenoble, France
 
  #69 Synthetic studies towards a nitroreductase-activated Cy7 based fluorescent probe
Elvira García de Jalón 1,2, Endre Stigen 2, Mireia Mayoral 2, Kjetil Børve Lund 2, Bengt Erik Haug 1, Emmet Mc Cormack 2
1University of Bergen Department of Chemistry and Centre for Pharmacy, Allégate 41, 5007 Bergen, Norway
2University of Bergen. Haukeland University Hospital Hematology Section, Department of Clinical Science and Department of Internal Medicine, Jonas Lies veg 87, 5021 Bergen, Norway
 
  #70 New transgenic reporter mouse to study live gelling mucin and mucous cell density
Céline Portal 1,2,3, Valérie Gouyer 1,2,3, Frédéric Gottrand 1,2,3, Jean-Luc Desseyn 1,2,3
1Inserm LIRIC U995, 1 place de Verdun, 59045 Lille, France
2Université Lille, 1 place de Verdun, 59045 Lille, France
3CHU Lille, 1 place de Verdun, 59045 Lille, France
 
  #71 Positively charged microbubbles for gene transfer in the liver using sonoporation triggered under ultrasound imaging.
Gilles Renault1, Anthony Delalande2, Simona Manta3, Michel-Francis Bureau3, Patrick Midoux2, Scherman Daniel3, Chantal Pichon2, Nathalie Mignet3
1Paris Descartes University, Cochin hospital, Ultrasound Imaging platform - Paris, France
2CNRS UPR 4301, Centre de Biophysique Moléculaire - Orleans, France
3UTCBS, CNRS UMR8258, INSERM U1022, Paris Descartes University, Chimie Paris tech - Paris, France
 
  #72 RESURGENCE OF DEVELOPMENTAL MECHANISMS AFTER ISCHEMIC STROKE IN ADULT MICE
Dunja Gorup 1, Ivan Bohaček 1,2, Tena Miličević 1, Roland Pochet 1,3, Dinko Mitrečić 1, Jasna Kirž 2, Srećko Gajović 1
1Croatian Institute for Brain Research, School of Medicine, University of Zagreb Department of Neurogentics, Salata 12, 10000 Zagreb, Croatia
2Research Centre of Institute Universitaire en Santé Mentale, Laval University Department of Psychiatry and Neuroscience, Quebec City Quebec G1J2G3a, Canada
3Faculty of Medicine, Université Libre de Bruxelles Laboratory of Histopathology, 808 Route de Lennik, B-1070 Brussels, Belgium
 
  #73 A bio-inspired amphiphile for tumor-targeted photoacoustic liposomes: in vitro and in vivo study
Nataliia Beztsinna 1,2, Yoanna Tsvetkova 3, Wa'el Al Rawashdeh 3, Twan Lammers 3, Fabian Kiessling 3, Isabelle Berque-Bestel 2
1Utrecht University Utrecht Institute for Pharmaceutical sciences, Universiteitsweg 99, 3584 CG Utrecht, Netherlands
2Université de Bordeaux CBMN UMR 5248, 14 Allée Geoffroy St Hiliare, 33600 Pessac, France
3RWTH Aachen University Clinic Experimental Molecular Imaging (ExMI), Pauwelsstraße 30, 52074 Aachen, Germany
 
  #74 In vivo ultrasound imaging and activation of an acoustic cluster therapy (ACT) agent with optical and optoacoustic assessment of reporter dye delivery enhancement
Nigel Bush 1, Andrew Healey 2, Per Christian Sontum 2, Svein Kvåle 2, Gary Box 3, Sue Eccles 3, Anant Shah 1, Annemieke van Wamel 4, Catharina de Lange Davies 4, Jeffrey Bamber 1
1The Institute of Cancer Research Joint Department of Physics and CRUK Cancer Imaging Centre, 15 Cotswold Road, Sutton, SM2 5NG, United Kingdom
2Phoenix Solutions AS, Nycoveien 2, N-0485 Nydalen, Norway
3The Institute of Cancer Research Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, SM2 5NG, United Kingdom
4NTNU Department of Physics, Realfagbygget, Høgskoleringen 5, NO-7491 Trondheim, Norway
 
  #75 Imaging Tumour Cell Death Using C2Am labelled with a Near-infrared Fluorophore
Bangwen Xie 1, Andre Neves 1, Stefanie Mullins 2, Robert Wilkinson 2, Kevin Brindle 1
1University of Cambridge Cancer Research UK, Robinson Way, CAMBRIDGE, CB2 0RE, United Kingdom
2MedImmune Limited, Granta Park, CAMBRIDGE, CB21 6GH, United Kingdom
 
top PW 04 - MRI and MPI | Technology & Methods
Chair: Arnaud Comment, Olivier Clément
  #80 Assessment of Thrombus Stage by ‘Multicolor’ 19F MRI
Sebastian Temme 1, Christoph Jacoby 2, Christoph Owenier 1, Christoph Grapentin 3, Xiaowei Wang 4, Rolf Schubert 3, Karlheinz Peter 4, Jürgen Schrader 1, Ulrich Flögel 1,2
1Heinrich-Heine-Universität Institut für Molekulare Kardiologie, Universitätsstraße 1, 40225 Düsseldorf, Germany
2Universitätsklinik Düsseldorf Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsstraße 1, 40225 Düsseldorf, Germany
3Albert-Ludwigs Universität Pharmazeutische Technologie und Biopharmazie, Hermann-Herder Straße 9, 79104 Freiburg i.Br., Germany
4Baker IDI Heart & Diabetes Institute Atherothrombosis and Vascular Biology, 75 Commercial Road, Melbourne 3400, Australia
 
  #81 19F ZTE MR Imaging of 19F labeled calcium phosphate cement at 11.7T
Weiqiang Dou 1, Simone Mastrogiacomo 2, Olga Koshkina 3, Andor Veltien 1, Mangala Srinivas 3, X. Frank Walboomers 2, Arend Heerschap 1
1Radboud University Medical Centre, Nijmegen, The Netherlands Department of Radiology, Radboud umc, Radiology Dept. (766), Postbus 9101, 6500 HB Nijmegen, Netherlands
2Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Biomaterials, Ph van Leijdenlaan 25, 6525EX Nijmegen, Netherlands
3Radboud University Nijmegen Medical Centre, Nijmegen Department of Tumor Immunology, RadboudUMC, Department of Tumor Immunology (278), Postbox 9101, 6500 HB Nijmegen, Netherlands
 
  #82 Magnetic Particle Imaging (MPI) for in vitro and in vivo intracellular iron quantification and cell detection
Päfgen Vera1, Straub Marcel1,2, Kiessling Fabian1, Schulz Volkmar1,2
1University Hospital Aachen, Experimental Molecular Imaging - Aachen, Germany
2University Hospital Aachen, Physics of Molecular Imaging - Aachen, Germany
 
  #83 In-vivo Measurements with UW-tracers in a harmonic 5.5 T/m MPI
Straub Marcel1, Päfgen Vera2, Teeman Eric3, Krishnan Kannan M.3, Kiessling Fabian2, Schulz Volkmar1
1University Hospital Aachen, Physics of Molecular Imaging - Aachen, Germany
2University Hospital Aachen, Experimental Molecular Imaging - Aachen, Germany
3University of Washington, Department of Materials Science - Seattle, United States
 
  #84 Heteronuclear Proton MRI - temperature effects and frequency separation of UTE versus CSI readout
Tim Klasen , Carsten Höltke , Cornelius Faber
University of Münster Department of Clinical Radiology, Albert-Schweitzer-Campus 1, Building A16, 48149 Münster, Germany
 
  #85 3D quantitative T1 and T2 MRI in a rabbit model of atherosclerosis at clinical 7T
Bram Coolen 1,2,3, Aimane Saarig 2, Hadrien Dyvorne 2, Bei Zhang 2, Aart Nederveen 3, Gustav Strijkers 1,2, Willem Mulder 2,4, Zahi Fayad 2, Claudia Calcagno 2
1Academic Medical Center Department of Biomedical Engineering and Physics, Amsterdam, Netherlands
2Translational and Molecular Imaging Institute Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY United States
3Academic Medical Center Department of Radiology, Amsterdam, Netherlands
4Academic Medical Center Department of Exp Vascular Medicine, Amsterdam, Netherlands
 
  #86 In vivo hyperpolarized 13C MRS studies in mice: an integrated device for clinical scanner
Alessandra Flori 1, Claudia Kusmic 2, Daniele de Marchi 3, Giovanni Donato Aquaro 3, Luca Menichetti 2,3, Giulio Giovannetti 2,3
1. Fondazione CNR/Regione Toscana G.Monasterio Bioengineering & Clinical Engineering Unit, via G. Moruzzi, 1, 56124 Pisa, Italy
2National Research Council (CNR) Institute of Clinical Physiology, via G. Moruzzi, 1, 56124 Pisa, Italy
3Fondazione CNR/Regione Toscana G.Monasterio, via G. Moruzzi, 1, 56124 Pisa, Italy
 
  #87 Relating in vivo MRI with histology images with multiple stainings
Vasilis Terzopoulos 1,2, Zhenhua Mai 3,1,4, Jelle Praet 3, Steve de Backer 5, Johan van Audekerke 3, Jan Sijbers 4, Darrel Pemberton 6, Mark Schmidt 6, Annemie van der Linden 3, Marleen Verhoye 3, Dirk Smeets 1,3
1Icometrix R&D, Leuven, Belgium
2Technische Universität München Institute for Biological and Medical Imaging, Munich, Germany
3University of Antwerp Bio-Imaging Lab, Antwerp, Belgium
4University of Antwerp iMinds - Vision Lab, Antwerp, Belgium
5DCI Labs, Keerbergen, Belgium
6Janssen Pharmaceutica NV, Beerse, Belgium
 
  #88 SPIO-enhanced MRI as a nondestructive in vivo Method to assess Vascularization of a 3D Matricel Collagen Scaffold planted on the Chorioallantoic Membrane of the Chick Embryo in ovo
Conny F. Waschkies 1,2, Fatma Kivrak Pfiffner 3, Yinghua Tian 2, Maurizio Calcagni 3, Pietro Giovanoli 3, Markus Rudin 1, Johanna Buschmann 3
1ETH and University Zurich Institute for Biomedical Engineering, Wolfgang-Pauli-Str. 27, HIT E22.3, 8093 Zurich, Switzerland
2University Hospital Zurich Division of Visceral and Transplantation Surgery, Sternwartstrasse 14, 8091 Zurich, Switzerland
3University Hospital Zurich Plastic Surgery and Hand Surgery, Sternwartstrasse 14, 8091 Zurich, Switzerland
 
  #89 T1 Longitudinal quantification of iron-oxyde particles using a 3D UTE Look-Locker sequence at 7T
Emeline Ribot , Charles Castets , Neha Koonjoo , Sylvain Miraux
Centre de Résonance Magnétique des Systèmes Biologiques CNRS/University Bordeaux, 146 rue Léo Saignat, 33700 Bordeaux, France
 
  #90 Multimodal Imaging of the Prostate with combined 11CAcetate PET/MRI
Stephan Polanec 1, Piotr Andrzejewski 2, Pascal Baltzer 1, Martin Susani 3, Thomas Helbich 1, Georgios Karanikas 1, Dietmar Georg 2, Katja Pinker-Domenig 1
1Akh Vienna Department of Biomedical Imaging and Image-guided Therapy, Währingergürtel 18-20, 1090 Vienna, Austria
2Akh Vienna Radiotherapy, Währingergürtel 18-20, 1090 Vienna, Austria
3Akh Vienna Pathology, Währingergürtel 18-20, 1090 Vienna, Austria
 
  #91 SQUID based magnetic resonance imaging for the investigation of hyperpolarized samples
Kai Buckenmaier 1, Matthias Rudolph 2, Miszal Tomasz 3, Juri Rudin 1, Hermann Mayer 3, Dieter Koelle 2, Reinhold Kleiner 2, Klaus Scheffler 1
1Max Planck Institute for Biological Cybernetics High-Field Magnetic Resonance Center, Spemannstr. 41, 72076 Tuebingen, Germany
2Universität Tübingen Physikalisches Institut and Center for Collective Quantum Phenomena in LISA+, Auf der Morgenstelle 14, 72076 Tuebingen, Germany
3Universität Tübingen Institut für Anorganische Chemie, Auf der Morgenstelle 18, 72076 Tuebingen, Germany
 
  #92 PHIP of fluorinated quaternary pyridinium ions
Frederike Euchner 1, Ute Bommerich 1, Rainer Ringleb 1, Joachim Bargon 2, Johannes Bernarding 1, Markus Plaumann 1
1Otto-von-Guericke-University Magdeburg Department for Biometrics and Medical Informatics, Leipziger Str. 44, 39120 Magdeburg, Germany
2University of Bonn Institute of Physical Chemistry, Wegelerstrasse 12, 53115 Bonn, Germany
 
  #93 MRI Demonstrated Hepatobiliary Changes in Human Liver Fluke Infection after Praziquantel Treatment: Animal Model
Petcharakorn Hanpanich 1, Thewarach Laha 2,3, Banchob Sripa 4,3, Eimorn Mairiang 1, Prasarn Tangkawattana 5,3, Sirikachorn Tangkawattana 6,3
1Khon Kaen University Radiology, Mittraparp, Khon Kaen 40002, Thailand
2Khon Kaen University Parasitology, Mittraparp, Khon Kaen 40002, Thailand
3Khon Kaen University Tropical Disease Research Laboratory, Mittraparp, Khon Kaen 40002, Thailand
4Khon Kaen University Pathology, Mittraparp, Khon Kaen 40002, Thailand
5KhonKaen University Veterinary Anatomy, Mittraparp, Khon Kaen 40002, Thailand
6Khon Kaen University Veterinary Pathobiology, Mittraparp, Khon Kaen 40002, Thailand
 
  #94 Diffusion-Weighted Imaging of Breast Lesions – Region-of-Interest Placement and Different ADC Parameters Influence Apparent Diffusion Coefficient Values, Reproducibility, and Diagnostic Performance
Hubert Bickel 1, Katja Pinker 1, Stephan Polanec 1, Heinrich Magometschnigg 1, Georg Wengert 1, Claudio Spick 1, Wolfgang Bogner 1, Zsuzsanna Bago-Horvath 2, Thomas Helbich 1, Pascal Baltzer 1
1Medical University Vienna Dpt. of Biomedical Imaging and Image Guided Therapy, Wachringer Guertel 18-20, 1090 Vienna, Austria
2Medical University Vienna Dpt. of Pathology, Wachringer Guertel 18-20, 1090 Vienna, Austria
 
top PW 05 - Advanced Mass Spectrometry Imaging Technology
Chair: John Fletcher, Andras Kiss
  #140 Elemental Imaging for preclinical and medical applications
Lucie Sancey 1, Benoit Busser 1,2, Florian Trichard 1, Frédéric Pelascini 3, Nicole Pinel 4, Olivier Tillement 1, Jean-Luc Coll 2, Julie Charles 4, Vincent Motto-Ros 1
1Institut Lumière Matière, UMR5306 Univ. Lyon 1-CNRS Team FENNEC, 2 rue V. Grignard, 69622 Villeurbanne, France
2Inserm U823-IAB, Univ. Grenoble Alpes, CHU de Grenoble, 38000 Grenoble, France
3CRITT Matériaux Alsace, 67305 Schiltigheim, France
4CHU Grenoble, 38000 Grenoble, France
 
  #141 In vivo metabolite analysis of anti-angiogenic PET tracer [11C]nintedanib using a newly developed LC-MS/MS method.
Slobbe Paul, Hauman Rianne, Schuit Robert C., van Dongen Guus, Windhorst Albert D., Poot Alex
VU University Medical Center, Radiology & Nuclear Medicine - Amsterdam, Netherlands
 
  #142 Complementary information by ambient low-temperature plasma mass spectrometry imaging
Kooijman Pieter1, Verhoeven Bart.2, Ellis Shane1, Heeren Ron M. A.1
1Maastricht University, M4I Institute - MAASTRICHT, Netherlands
2Maastricht University, IDEE - MAASTRICHT, Netherlands
 
  #143 Optimal on-tissue enzymatic digestion conditions for direct protein analysis on fresh frozen tissue preceding matrix-assisted laser desorption/ionization (MALDI) MSI analysis.
Martha Ingola , Jo Cappell , Tiffany Porta , Ron M. A. Heeren
Maastricht university M4i, Universiteitssingel 50, 6229 ER Maastricht, Netherlands
 
  #144 Mass spectrometry imaging as a tool to visualize drug distribution and metabolism
Huizing Lennart1, Flinders Bryn1, Vreeken Rob1,2, Heeren Ron M. A.1
1Maastricht University, M4I-MSI - Maastricht, Netherlands
2Janssen, R&D - Beerse, Belgium
 
  #145 Molecular profiling of cholangiocarcinoma and its potential for clinical implication
Tiffany Porta 1, Keely Pierzchalski 1, Klara Scupakova 1, Jessica Wappler 2, Lara Heij 3, Thorsten Cramer 2, Ulf P. Neumann 2, Heike Grabsch 3, Axel zur Hausen 3, Steven W.m. Olde Damink 4, Ron M.a. Heeren 1
1Maastricht University M4I institute, Maastricht, Netherlands
2RWTH Universitätsklinikum, Aachen, Germany
3Maastricht University Medical Center+ Department of Pathology, Maastricht, Netherlands
4Maastricht University Medical Center+ Department of Surgery, Maastricht, Netherlands
 
  #146 Multispectral high resolution imaging of tumour spheroids using Light Sheet Fluorescence Microscopy (LSFM)
Stylianos E. Psycharakis 1, Evangelos Liapis 1, Ilias Kyparissidis-Kokkinidis 1, Athanasios Zacharopoulos 1, Joseph Papamatheakis 2, Jorge Ripoll 3, Giannis Zacharakis 1
1Foundation for Research and Technology - Hellas Institute of Electronic Structure & Laser, 100 Nikolaou Plastira str, Vassilika Vouton, 70013 Heraklion, Crete, Greece
2Foundation for Research and Technology - Hellas Institute of Molecular Biology and Biotechnology, 100 Nikolaou Plastira str, Vassilika Vouton, 70013 Heraklion, Crete, Greece
3Universidad Carlos III de Madrid Department of Bioengineering and Aerospace Engineering, Madrid, Spain
 
  #147 The effect of heat stabilization on lipid profiles in mouse liver by Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging (MALDI-MSI).
Arts Martijn 1,2, Pierzchalski Keely 2, Dubois Ludwig 3, Soons Zita 1, Heeren Ron Ma 2, Olde-Damink Steven 1
1Maastricht University Medical Center+ Department of Surgery - Maastricht, Netherlands
2Maastricht University Division of Mass Spectrometry Imaging, M4I - Maastricht, Netherlands
3Maastricht University Medical Center+ Radiation Oncology (Maastro) - Maastricht, Netherlands
 
top PW 06 - Immunology and Inflammation
Chair: Manfred Kneiling, Henryk Faas
  #149 Follow up of paw inflammation and bone lesions in a mouse model of psoriatic arthritis using fluorescence and X-Ray imaging
Catherine Robin-Jagerschmidt 1, Stéphanie Lavazais 2, Emilie Chanudet 1, Isabelle Parent 2, Marielle Auberval 1, Anna Yudina 3
1Galapagos in vivo pharmacology, 102 avenue Gaston Roussel, 93230 Romainville, France
2Galapagos translational sciences, 102 avenue Gaston Roussel, 93230 Romainville, France
3Bruker Biospin, 34 rue de l’Industrie, 67166 Wissembourg, France
 
  #150 What would be the optimal combination of inflammation imaging and tissue analysis for cardiovascular risk assessment?A study in Non-Human Primates under atherogenic diet
Vanessa di Cataldo 1, Joao Piraquive Agudelo 2, Hugues Contamin 3, Alain Geloen 1, Clément Grandin 3, André Serusclat 4, Franck Lamberton 2, Danielle Ibarolla 2, Franck Lavenne 2, Didier Le Bars 2, Emmanuelle Canet-Soulas 1
1CarMeN Laboratory, INSERM U1060, Faculté de Médecine Lyon Sud, 69600 OULLINS, France
2CERMEP Groupement hospitalier Est, Boulevard Pinel, 69677 BRON, France
3CYNBIOSE, Avenue Bourgelat, 69280 Marcy l'Etoile, France
4Hopital Louis Pradel Department of Radiology, Boulevard Pinel, 69677 BRON, France
 
  #151 Involvement of Vascular Adhesion Protein-1 in Development of Inflammatory Lesions in Rat Models of Multiple Sclerosis
Petri Elo 1, Sina Tadayon 1, Heidi Liljenbäck 1,2, Käkelä Meeri 1, Kalle Koskensalo 3, Virva Saunavaara 3, Jenni Virta 1, Aida Kiviniemi 1,3,4, Antti Saraste 1, Päivi Marjamäki 1, Laura Airas 5, Sirpa Jalkanen 1,6, Anne Roivainen 1,2,3
1University of Turku Turku PET Centre, Kiinamyllynkatu 4-8, 20521 Turku, Finland
2University of Turku, Turku Center for Disease Modeling, Kiinalyllynkatu 10, 20520 Turku, Finland
3Turku University Hospital Turku PET Centre, Kiinamyllynkatu 4-8, 20521 Turku, Finland
4Turku University Hospital Department of Radiology, Medical Imaging Centre of Southwest Finland, Kiinamyllynkatu 4-8, 20521 Turku, Finland
5Turku University Hospital Department of Neurology, Hämeentie 11, 20521 Turku, Finland
6University of Turku MediCity Research Laboratory, Tykistökatu 6, 20520 Turku, Finland
 
  #152 Easy and efficient method to reduce bladder FDG signal on small animals PET-CT
Ana Villarejo 1, Lorena Cussó 1,2,3, Manuel Desco 1,2,3
1Instituto de Investigación Sanitaria Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, Spain
2Universidad Carlos III de Madrid Departamento de Bioingeniería e Ingeniería Aeroespacial, Avda. Universidad 30, 28911 Madrid, Spain
3Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Monforte de Lemos 3-5, 28029 Madrid, Spain
 
  #153 [18F]fluoro-PEG-folate as a potential tracer for monitoring anti-folate therapy in rheumatoid arthritis
Chandrupatla D.m.s.h1, Molthoff Carla2, Greeuw I.de3, Verlaan M2, van Kooij R.2, Al M.1, Windhorst Albert D.2, Chen Q4, Low Philip4, Lammertsma Adriaan A.2, Jansen G.1, van der Laken C. J.1
1Amsterdam Rheumatology and Immunology Centre (ARC│VU University Medical Centre), Dept. of Rheumatology - Amsterdam, Netherlands
2VU University Medical Centre, Dept. of Radiology and Nuclear Medicine - Amsterdam, Netherlands
3VU University, HRM, Arbo & milieu - Amsterdam, Netherlands
4Purdue University, Dept. of Chemistry - West Lafayette, United States
 
  #155 Monitoring allograft rejection with and without immunosuppressive treatment by glucoCEST MRI
Bovenkamp Philipp 1, Kentrup Dominik 2, Busch Annika 1, Pawelski Helga 2, Yadav Nirbhay 3,4, Liu Guanshu 3,4, van Zijl Peter 3,4, Reuter Stefan 2, Hoerr Verena 5,1
1University Hospital Münster Department of Clinical Radiology - Münster, Germany
2University Hospital Münster Department of Medicine D - Experimental Nephrology - Münster, Germany
3John Hopkins University School of Medicine Russel H. Morgan Department of Radiology and Radiological Science - Baltimore, United States
4Kennedy Krieger Research Institute F.M. Kirby Research Center of Functional Brain Imaging - Baltimore, United States
5Jena University Hospital Istitute of Medical Microbiology - Jena, Germany
 
  #156 'Characterization of the inflammatory process in two in vivo animal models of Neurodegeneration using PET and the TSPO radioligand [18F]DPA-714'
Géraldine Pottier 1, Nicholas Bernards 2,1, Joanne Solet 1, Frédéric Dollé 1, Raphaël Boisgard 1
1Inserm / CEA / Université Paris Sud, UMR 1023 – ERL 9218 CNRS, IMIV, Orsay, France, 4 place du Général Leclerc, 91401 Orsay, France
2STTARR/TECHNA/UHN, 101 College street, Toronto Ontario M5G 1L7, Canada
 
  #157 Pre-clinical evaluation of inflammatory response after implantation of bone-conductive biomaterials by non-invasive optical imaging in a calvarial defect mouse model
A. M. Markus 1,2, Christian Dullin 3, C. Kampleitner 4, L. Poocza 5, C. Gonzalez 6, M. Espanol 7, J. C. Rodriguez-Cabello 6, G. Hildebrand 5, O. Hoffmann 4, Frauke Alves 1,2
1Max-Planck-Institute for Experimental Medicine Molecular Biology of Neuronal Signals, Hermann-Rein-Straße 3, 37075 Göttingen, Germany
2University Medical Centre Dept. of Haematology and Medical Oncology, Robert-Koch-Straße 40, 37075 Göttingen, Germany
3University Medical Centre Department of Diagnostic and Interventional Radiology, Robert-Koch-Straße 40, 37075 Göttingen, Germany
4University of Vienna Dept. of Pharmacology and Toxicology, Universitätsring 1, 1010 Vienna, Austria
5Institute for Bioprocessing and Analytical Measurement Techniques Dept. of Biomaterials, Rosenhof, 37308 Heiligenstadt, Germany
6University of Valladolid Bioforge, C/Plaza de Santa Cruz 8, 47002 Valladolid, Spain
7Universitat Politècnica de Catalunya; BarcelonaTech Biomaterials; Biomechanics and Tissue Engineering Group; Dept. Materials Science and Metallurgical Engineering, Calle Jordi Girona 31, 08034 Barcelona, Spain
 
  #158 Eosinophil skin infiltration in the calcipotriol-induced atopic dermatitis-like mouse model
Catherine Robin-Jagerschmidt 1, Stéphanie Lavazais 2, Florence Marsais 3, Emilie Chanudet 1, Marielle Auberval 1, Anna Yudina 4
1Galapagos In vivo pharmacology, 102 avenue Gaston Roussel, 93230 Romainville, France
2Galapagos Translational sciences, 102 avenue Gaston Roussel, 93230 Romainville, France
3Galapagos Histology, 102 avenue Gaston Roussel, 93230 Romainville, France
4Bruker Biospin, 34 rue de l'Industrie, 67166 Wissembourg, France
 
  #159 Imaging joint inflammation with 111In-Octreoscan
Sandra van Tiel 1, Lizette Utomo 2, Jan de Swart 3, Marion Hendriks-de Jong 4,5, Yvonne Bastiaansen-Jenniskens 6, Monique Bernsen 7,8
1PhD student Radiology, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
2PhD student Orthopedics, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
3BSc Nuclear Medicine, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
4Professor Nuclear Medicine, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
5Professor Radiology, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
6Assistant professor Orthopedics, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
7Assistant professor Radiology, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
8Assistant professor Nuclear Medicine, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
 
  #160 Stable Fe-citrate effect on 68Ga-citrate tissue distribution for fast PET imaging of inflammation/infection
Aleksandr Lunev 1,2, Kristina Petrosova 2, Anton Larenkov 2, Olga Klementyeva 2, Galina Kodina 2
1Moscow State Academy of Veterinary Medicine and Biotechnology Radiobiology, Skryabin academic, 109472 Moscow, Russia
2Burnasyan Federal Medical Biophysical Center of FMBA Russia Radiation Technologies in Nuclear Medicine, Zhivopisnaya, 46, 123098 Moscow, Russia
 
  #161 Chronic Neural Inflammatory Response to High Dose Radiotherapy Monitored Using 18F-DPA-714 PET and 1H MRS
Duncan Forster 1, Michael Kassiou 2, Kaye Williams 1
1University Of Manchester Institute of Population Health, 27 Palatine Road, Manchester, M20 3LJ, United Kingdom
2The University of Sydney School of Chemistry and Faculty of Health Sciences, Sydnew NSW2006, Australia
 
  #162 Following the homing patterns of 64Cu-PTSM- or 64Cu-1A8 antibody (Ab) labeled granulocytic myeloid derived suppressor cells (G-MDSC) in experimental rheumatoid arthritis (RA) by PET/MRI
Fuchs Kerstin1, Oez Hasan-Halit2, Carevic Melanie2, Altmeyer Natalie1, Bukala Daniel1, Hartl Dominik2, Pichler Bernd J.1, Kneilling Manfred1,3
1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen - Tübingen, Germany
2Department of Pediatrics I, Infectious Diseases & Immunology, Eberhard Karls University Tübingen - Tübingen, Germany
3Department for Dermatology, Eberhard Karls University Tübingen - Tübingen, Germany
 
  #163 Monitoring liver fibrosis disease progression and resolution with cell therapy.
Connell John, Ramasawmy Raj, Roberts Tom, Zaw-Thin May, Patrick Stephen, Eoin O'fionnachta, Walker-Samuel Simon, Lythgoe Mark, Kalber Tammy
University College London, Centre for Advanced Biomedical Imaging - London, United Kingdom
 
  #164 Epidermal dendritic cells’ morphology of atopic dermatitis skin by multi-photon imaging
Gwendal Josse 1, Jimmy Le Digabel 1, Marion Martin 2, Aurelie Villaret 1, Muriel Golzio 2, Daniel Redoules 1
1Skin Research Center - PFDC Biophysics & Imaging, Toulouse, France
2Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
 
  #165 In vivo MRI monitoring of phagocyte migration in mouse brain at 7T
Hubert Violaine 1,2, Chauveau Fabien 3, Durand Anne 4, Cho Tae-Hee 4, Bolbos Radu 5, Canet-Soulas Emmanuelle 1,2, Wiart Marlène 2
1Université de Lyon Lyon 1 - Villeurbanne, France
2Cardiovascular, Metabolism, Diabetes, and Nutrition (CarMeN Laboratory), University Lyon 1, INSERM U.1060, INRA U.1397 - Bron, France
3Centre de Recherche en Neurosciences de Lyon (CRNL), Inserm U1028 - CNRS UMR5292 - Bron, France
4CREATIS (CNRS UMR 5220), INSERM, University Claude Bernard Lyon1 - Villeurbanne, France
5CERMEP - Bron, France
 
  #166 Photoacoustic imaging of macrophages using gold nanorods
Cinzia Avigo 1, Claudia Borri 2,3, Claudia Kusmic 1, Paolo Armanetti 4, Nicole di Lascio 5,1, Francesco Faita 1, Sonia Centi 3, Lucia Cavigli 3, Roberto Pini 3, Fulvio Ratto 3, Luca Menichetti 1,6
1Institute of Clinical Physiology National Research Council, G. Moruzzi, 1, 56124 Pisa, Italy
2Dipartimento di scienze biomediche sperimentali e cliniche "Mario Serio" Università di Firenze, Firenze, Italy
3Institute of Applied Physics “N. Carrara” National Research Council, Via Madonna del Piano, 10, 50019 Sesto Fiorentino (FI), Italy
4Department of Physics “E. Fermi” University of Pisa, Largo Bruno Pontecorvo, 3, 56127 Pisa, Italy
5Scuola Superiore Sant'Anna, Piazza Martiri della Libertà, 33, 56127 Pisa, Italy
6Fondazione CNR/Regione Toscana G.Monasterio, via G. Moruzzi, 1, 56124 Pisa, Italy
 
  #167 Optical imaging of phagocyte migration in inflammatory processes in vivo.
Sandra Gran 1, Zenker Stefanie 1, Michael Schäfers 2, Johannes Roth 1, Thomas Vogl 1
1Institute of Immunology, Röntgenstraße 21, 48149 Münster, Germany
2European Institute for Molecular Imaging, Waldeyerstraße 15, 48149 Münster, Germany
 
top PW 07 - Novel Diagnostic and Therapeutic Imaging Strategies in Oncology
Chair: Susanne Kossatz, Eric Kaijzel
  #190 Modeling cellular dosimetry for molecular radiotherapy: computation of dose distribution in 3D tumor cell spheroids
Reijonen Vappu 1, Kanninen Liisa 2, Hippeläinen Eero 3,4, Lou Yan-Ru 2, Salli Eero 3, Sofiev Alexey 3,4, Malinen Melina 2, Paasonen Timo 3,4, Yliperttula Marjo 2, Kuronen Antti 4, Savolainen Sauli 3,4
1Helsinki University Hospital Cancer Center - Helsinki, Finland
2University of Helsinki Centre for Drug Research - Helsinki, Finland
3Helsinki University Hospital HUS Medical Imaging Center - Helsinki, Finland
4University of Helsinki Department of Physics - Helsinki, Finland
 
  #191 Longitudinal in vivo tumor cell tracking using a CT/fluorescence liposome labeling agent
Manuela Ventura 1, Linyu Fan 1, Jinzi Zheng 1,2
1TECHNA Institute for the Advancement of Technology for Health, University Health Network – Toronto, Ontario, Canada, 101 College street, Toronto ON M5G 1L7, Canada
2Institute of Biomaterials & Biomedical Engineering, University of Toronto – Toronto, Ontario, Canada, Toronto ON Canada
 
  #192 Characterizing pathophysiological mechanisms underlying EPR mediated tumor accumulation
Susanne K. Golombek 1, Robert Pola 2, Michael Pechar 2, Dionne Klein 3, Fabian Kiessling 1, Twan Lammers 1
1RWTH Aachen University Clinic Experimental Molecular Imaging Institute, Pauwelsstraße 20, 52074 Aachen, Germany
2Academy of Sciences Institute of Macromolecular Chemistry, Heyrovský square 2, 162 06 Prague, Czech Republic
3RWTH Aachen University Clinic Institute for Molecular Cardiovascular Research, Pauwelsstraße 20, 52074 Aachen, Germany
 
  #193 Immune-checkpoint blockade strongly amplifies CD4+ T cell driven antitumoral therapy in mice with progressed pancreatic cancer
Barbara F. Schörg 1, Dominik Krüger 1, Christoph M. Griessinger 1, Sabrina Eilenberger 1, Gerald Reischl 1, Walter Ehrlichmann 1, Ursula Kohlhofer 2, Leticia Quintanilla-Martinez 2, Martin Röcken 3, Bernd J. Pichler 1, Manfred Kneilling 1,3
1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tuebingen, Röntgenweg 13, 72076 Tuebingen, Germany
2Department of Pathology, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany
3Department of Dermatology, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany
 
  #194 Preclinical evaluation of 68Ga-DOTA-NT20.3 as a PET imaging agent for neurotensine receptor-1 expression in a model of exocrine pancreatic adenocarcinoma.
Prignon Aurélie1, Provost Claire1, Gruaz-Guyon Anne1, Talbot Jean-Noël1,2
1UPMC, Laboratoire d'Imagerie Moléculaire Positonique - Paris, France
2APHP, Department of Nuclear Medicine - Paris, France
 
  #195 c-Met PET Imaging Detects Early Stage Loco-Regional Recurrence of Basal-Like Breast Cancer
Appitha Arulappu 1, Mark Battle 2, Michel Eisenblaetter 1, Mcrobbie Graeme 2, Imtiaz Khan 2, James Monypenny 1, Gregory Weitsman 1, Myria Galazi 3, Susan Hoppmann 2, Patrycja Gazinska 4, Wulan Wulaningsih 1, Grethe Tang Dalsgaard 2, Sven MacHoll 5, Tony Ng 1,3
1King's College London Richard Dimbleby Department of Cancer Research, London, United Kingdom
2GE Healthcare Life Sciences, London, United Kingdom
3UCL Cancer Institute University College London, London, United Kingdom
4Breast Cancer NOW Uni King's College London School of Medicine, London, United Kingdom
5Queen Mary University Barts Cancer Institute, London, United Kingdom
 
  #196 [18F]FLT PET Visualizes Recovery of Hematopoietic Organs in Mice after Therapy with the Myelosuppressive Agent Gemcitabine
Sonja Schelhaas 1, Annelena Held 1, Nicole Bäumer 2, Thomas Viel 1,3, Sven Hermann 1, Carsten Müller-Tidow 2,4, Andreas H. Jacobs 1,5
1University of Münster European Institute for Molecular Imaging, Waldeyerstr. 15, 48147 Münster, Germany
2Universityhospital of Münster Department of Hematology and Oncology, Münster, Germany
3Université Paris Descartes PARCC INSERM, Paris, France
4University Hospital Halle Department of Hematology and Oncology, Halle, Germany
5Johanniter Hospital Bonn Department of Geriatric Medicine, Bonn, Germany
 
  #198 Photopharmacology: light-controlled therapy for theranostics
Wiktor Szymanski 1,2, Ben L. Feringa 2
1University Medical Center Groningen Department of Radiology, Hanzeplein 1, 9713GZ Groningen, Netherlands
2University of Groningen Stratingh Institute, Nijenborgh 7, 8747AG Groningen, Netherlands
 
  #199 Assessment of Doxorubicin Penetration in the Tumor Microenvironment after Release from Thermosensitive Liposomes during Mild Hyperthermia
Marc Derieppe 1, Baudouin Denis de Senneville 1,2, Jean-Michel Escoffre 1, Quincy van Houtum 1, Angelique Barten 1, Clemens Bos 1, Chrit Moonen 1
1University Medical Center Utrecht Imaging Division, Heidelberglaan 100 P.O. Box 85500, Utrecht, Netherlands
2UMR 5251, CNRS, Université de Bordeaux Institut de Mathématiques de Bordeaux, 351, cours de la Libération, F33405 Talence, France
 
  #200 Assessment of tumour progression and response to treatment in a glioma animal model using a set of imaging procedures
Silvia Valtorta 1,2, Cristina Martelli 3,4, Letterio Salavatore Politi 5, Isabella Raccagni 2,6, Cecilia Diceglie 7, Sara Belloli 1,2, Francesco Sudati 2, Giuseppe di Grigoli 1,2, Luigi Gianolli 2, Giovanni Lucignani 4,8,9, Luisa Ottobrini 1,3,4, Rosa Maria Moresco 2,6
1Institute of Molecular Bioimaging and Physiology, National Researches Council (IBFM-CNR), Segrate, Italy
2IRCCS San Raffaele Scientific Institute Experimental Imaging Center, Milano, Italy
3University of Milan Department of Medical-Surgical Physiopathology and Transplants, Segrate, Italy
4University of Milan Centre of Molecular and Cellular Imaging-IMAGO, Segrate, Italy
5IRCCS San Raffaele Scientific Institute Department of Neuroradiology and Neuroradiology Research Group, Milano, Italy
6University of Milan-Bicocca Department of Medicine and Surgery, Monza, Italy
7Tecnomed Foundation of University of Milan-Bicocca, Monza, Italy
8University of Milan Department of Health Sciences, Milano, Italy
9San Paolo Hospital Department of Diagnostic Services, Unit of Nuclear Medicine, Milano, Italy
 
  #201 Image-guided neurosurgical resection using an activated probe and a multimodality optical device for wide-field fluorescence and in vivo microscopy
Stephan Rogalla 1, Michael Mandella 1, Megan Garland 2, Matthew Bogyo 2, Christopher H. Contag 1
1Stanford University Pediatrics, 318 Campus Drive, Stanford, CALIFORNIA 94305, United States
2Stanford University Pathology, 300 Pasteur Drive, Stanford, CALIFORNIA 94305, United States
 
  #202 Diffusion-weighted magnetic resonance imaging of breast lesions: a prospective clinical investigation of reproducibility, repeatability and diagnostic accuracy
Claudio Spick 1, Hubert Bickel 1, Katja Pinker-Domenig 1, Maria Bernathova 1, Ramona Woitek 1, Panagiotis Kapetas 1, Paola Clauser 1, Stephan Polanec 1, Margaretha Rudas 2, Thomas Helbich 1, Pascal Baltzer 1
1Medical University of Vienna Department of biomedical imaging and image-guided therapy, Waehringer Guertel 18-20, 1090 Vienna, Austria
2Medical University of Vienna Clinical institute of pathology, Vienna, Austria
 
  #203 Cell-Uptake Kinetics of Doxorubicin in the Tumor Microenvironment after Release from Thermosensitive Liposomes during Mild Hyperthermia
Marc Derieppe 1, Jean-Michel Escoffre 1, Baudouin Denis de Senneville 1,2, Angelique Barten 1, Quincy van Houtum 1, Clemens Bos 1, Chrit Moonen 1
1University Medical Center Utrecht Imaging Division, Heidelberglaan 100 P.O. Box 85500, Utrecht, Netherlands
2UMR 5251, CNRS, Université de Bordeaux Institut de Mathématiques de Bordeaux, 351, cours de la Libération, F33405 Talence, France
 
  #204 Extracellular vesicles radiolabeled with 99mTc for quantitative in vivo imaging studies
Varga Zoltan 1, Gyurko Istvan 1, Paloczi Krisztina 2, Buzas Edit 2, Szigeti Krisztian 3, Mathe Domokos 4
1Research Centre for Natural Sciences, Hungarian Academy of Sciences Biological Nanochemistry Research Group, Institute of Materials and Environmental Chemistry, Budapest, Hungary
2Semmelweis Univerisity Department of Genetics, Cell- and Immnune Biology, Budapest, Hungary
3Semmelweis University Dept. of Biophysics and Raditation Biology, Budapest, Hungary
4CROmed Research and Service Centers Ltd, Budapest, Hungary
 
  #205 Dose exposure assessment of 223Ra during external manipulation and possibility of 223Ra SPECT imaging for image-derived internal dosimetry
Taba Gabriella 1, Kari Bela 2, Garai Ildiko 3, Szucs Eva 3, Arva Ferenc 4, Horvath Ildiko 5, Mathe Domokos 6
1Semmelweis University Radiation Protection Service, Budapest, Hungary
2Semmelweis University Nuclear Medicine Clinic, Budapest, Hungary
3Scanomed Ltd., Debrecen, Hungary
4Hungarian Academy of Sciences EK - Environmental Protection Service, Budapest, Hungary
5Semmelweis University Department of Biophysics and Radiation Biology, Budapest, Hungary
6CROmed Research and Service Centers Ltd., Budapest, Hungary
 
  #206 Hybrid-PET/MRI imaging: Orthotopic tumors show different tumor tissue characteristics than subcutaneously grown tumors
Eva Jolanthe Koziolek 1, Jakob Albrecht 1, Sarah Erdmann 2, Dietrich Polenz 3, Samantha Exner 2, Leder Annemarie 3, Nicola Beindorff 1, Winfried Brenner 1
1Charite Berlin Berlin Experimental Radionuclide Imaging Center, Augustenburger Platz 1, 13535 Berlin, Germany
2Charite Berlin Department of Hepatology and Gastroenterology, Molecular Cancer Research Center, Augustenburger Platz 1, 13535 Berlin, Germany
3Charite Berlin General, Visceral, and Transplantation Surgery Experimental Surgery and Regenerative Medicine, Augustenburger Platz 1, 13535 Berlin, Germany
 
  #207 AAC-11 inhibitor for melanoma therapy: longitudinal evaluation using 18F-FDG PET/CT in mice xenografts
Nicolas Vignal 1, Ewa Kotula 2, Fortune Hontonnou 3, Benoit Hosten 1,4, Vadim Tsoupko-Sitnikov 3, Nathalie Rizzo 1,4, Jean-Luc Poyet 2, Laure Sarda 3,5
1APHP St-Louis Hospital Radiopharmacy / UCK IUH, 1 av Claude Vellefaux, 75010 Paris, France
2Inserm St-Louis Hospital UMR-S1160, 27 rue Juliette Dodu, 75010 Paris, France
3IUH Paris Diderot University St-Louis Hospital Unité Claude Kellershohn, 1 av Claude Vellefaux, 75010 Paris, France
4Paris Descartes University Faculty of Pharmacy Inserm UMR-S1144, 4, avenue de l'Observatoire, 75006 Paris, France
5APHP Lariboisière Hospital Nuclear Medicine, 2 rue Ambroise Paré, 75010 Paris, France
 
top PW 08 - Tumour Metabolism
Chair: Kevin Brindle, Frauke Alves
  #210 A highly sensitive permanent switch to identify hypoxia effects on cancer cell invasion
Eleni Skourti 1, Gilbert Fruhwirth 2
1King's College London Imaging Chemistry and Biology, St Thomas Hospital, London, SE1 7EH, United Kingdom
2King's College London Imaging Chemistry and Biology, St Thomas Hospital, London, SE1 7EH, United Kingdom
 
  #211 MALDI-MS and [11C] acetate PET imaging of lipid heterogeneity in non-small-cell lung cancer
Fiona Henderson 1, David Lewis 2, Dmitry Soloviev 2, Kevin Brindle 2, Kaye Williams 3, Adam McMahon 1
1Wolfson Molecular Imaging Centre, University of Manchester, Palatine Rd, Manchester, M20 3LJ, United Kingdom
2Cancer Research United Kingdom—Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom
3Manchester Pharmacy School, Stopford Building, University of Manchester, Manchester, United Kingdom
 
  #212 Comparison of [18F]FAZA and [18F]FAZAL for in vivo hypoxia imaging in mice
Thomas Wanek 1, Katharina Kreis 1, Christoph Denk 2, Johann Stanek 1, Severin Mairinger 1, Thomas Filip 1, Michael Sauberer 1, Oliver Langer 1,3, Claudia Kuntner 1
1AIT Austrian Institute of Technology GmbH Health & Environment, Biomedical Systems, 2444 Seibersdorf, Austria
2Vienna University of Technology Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163, 1060 Vienna, Austria
3Medical University of Vienna Department of Clinical Pharmacology, 1090 Vienna, Austria
 
  #213 Quantitative multispectral optoacoustic tomography for imaging of apoptosis in vivo
Josefine Reber , Antonio Nunes , Nicolas Bézière , Vasilis Ntziachristos
Helmholtz Zentrum München Institute for Biological and Medical Imaging, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
 
  #214 Early [18F]FLT PET Imaging is not Predictive for Later Therapy Outcome in Gemcitabine Treated Lung Cancer Xenografts
Sonja Schelhaas 1, Annelena Held 1, Thomas Viel 1,2, Sven Hermann 1, Andreas H. Jacobs 1,3
1University of Münster European Institute for Molecular Imaging, Waldeyerstr. 15, 48147 Münster, Germany
2Université Paris Descartes PARCC INSERM, Paris, France
3Johanniter Hospital Bonn Department of Geriatric Medicine, Bonn, Germany
 
  #215 Daily metformin treatment may decrease NSCLC xenograft tumor growth in a cell line-dependent way, without affecting tumor oxygenation
de Bruycker Sven1, Vangestel Christel1,2, van Den Wyngaert Tim1,2, Dockx Yanina1, Wyffels Leonie1,2, Pauwels Patrick3, Staelens Steven1, Stroobants Sigrid1,2
1University of Antwerp, Molecular Imaging Center Antwerp - Antwerp, Belgium
2Antwerp University Hospital, Nuclear Medicine - Antwerp, Belgium
3University of Antwerp, Center for Oncological Research - Antwerp, Belgium
 
  #216 The Warburg effect at the steering wheel of cancer cell migration
Steven Wink , Hans de Bont , Bob van de Water , Sylvia Le Dévédec
LACDR/Leiden University TOXICOLOGY, Einsteinweg 55, 2333 CC LEIDEN, Netherlands
 
  #217 Monitoring tumor response to carbogen breathing by oxygen-sensitive MR parameters to predict the outcome of radiation therapy: a preclinical study
Thanh Trang Cao Pham , Ly-Binh-An Tran , Florence Colliez , Nicolas Joudiou , Bernard Gallez , Bénédicte Jordan
Biomedical Magnetic Resonance Group, Université Catholique de Louvain, Avenue E. Mounier 73, 1200 Brussels, Belgium
 
  #218 Impacts of Anthelmintic Fenbendazole Diet on Tumor [18F]FDG Uptake in Mice
Lin Yun, Calaminus Carsten, Pichler Bernd J.
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University - Tübingen, Germany
 
top PW 09 - Disease Models | Neuro-Imaging
Chair: Andreas Hess, Cindy Casteels
  #250 DTI connectomics in a mouse model of vascular dementia
Philipp Boehm-Sturm 1, Martina Füchtemeier 1, Marco Foddis 1, Marietta Zille 1,2, Susanne Mueller 1, Rebecca C. Trueman 3, Ivan Amat-Roldan 4, Ulrich Dirnagl 1, Tracy D. Farr 1,3
1Charité University Medicine Berlin Department of Experimental Neurology, Center for Stroke Research Berlin, Charitéplatz 1, 10117 Berlin, Germany
2Weill Medical College of Cornell University Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, New York 10605, United States
3University of Nottingham School of Life Sciences, Medical School, Queen’s Medical Centre, Nottingham, United Kingdom
4Expert Ymaging SL, Barcelona, Spain
 
  #251 Investigating mediators of neutrophil recruitment to the brain with near-infrared fluorescence imaging
Vaas M.1, Enzmann G.1,2, Licha Kai1,3, Rudin Markus1,4, Engelhardt B.1, Klohs J.1
1Institute for Biomedical Engineering, Institute for Biomedical Engineering - Zurich, Switzerland
2Theodor Kocher Institute, University of Bern - Bern, Switzerland
3IC Discovery GmbH - Berlin, Germany
4Institute of Pharmacology and Toxicology, University of Zurich - Zurich, Switzerland
 
  #252 A novel PET protocol for measuring multidrug resistance associated protein 1 function and beta-amyloid plaque load in mouse brain
Severin Mairinger 1, Thomas Wanek 1, Alexander Traxl 1, Markus Krohn 2, Johann Stanek 1, Thomas Filip 1, Michael Sauberer 1, Claudia Kuntner-Hannes 1, Jens Pahnke 2, Oliver Langer 1,3
1AIT Austrian Institute of Technology GmbH Health & Environment Department, 2444 Seibersdorf, Austria
2University of Oslo (UiO) and Oslo University Hospital (OUS) Department of Neuro-/Pathology, Oslo, Norway
3Medical University of Vienna Department of Clinical Pharmacology, Vienna, Austria
 
  #253 Longitudinal Investigation of neuroinflammation and neurodegeneration in TGF344-AD Rats.
Chaney Aisling, Williams Steve, Boutin Hervé
University of Manchester, Medicine - Manchester, United Kingdom
 
  #254 Striatal changes in mGluR5 and glutamate availability in the 6-hydroxydopamine rat model of Parkinson’s disease, with and without dyskinesia
Melissa Crabbé 1,2, Cindy Casteels 1,2, Anke van der Perren 2,3, Akila Weerasekera 2,4, Tinne Buelens 2, Uwe Himmelreich 2,4, Veerle Baekelandt 2,3, Koen van Laere 1,2
1Division of Nuclear Medicine KU Leuven and University Hospital Leuven, Leuven, Belgium
2MoSAIC, Molecular Small Animal Imaging Centre KU Leuven, Leuven, Belgium
3Laboratory for Neurobiology and Gene Therapy KU Leuven, Leuven, Belgium
4Biomedical MRI Unit KU Leuven, Leuven, Belgium
 
  #255 Dexamethasone reduces blood-brain barrier leakage during early epileptogenesis in the intra-hippocampal kainate mouse model
Martin Meier 1, Heike Breuer 2,3, Pablo Bascunana Almarcha 2, Marion Bankstahl 3, Jens P. Bankstahl 2
1Hannover Medical School Preclinical Imaging Labs, Institute for Laboratory Animal Science, Carl-Neuberg-Str.1, 30625 Hannover, Germany
2Hannover Medical School Preclinical Molecular Imaging, Department of Nuclear Medicine, Carl-Neuberg-Str.1, 30625 Hannover, Germany
3University of Veterinary Medicine Hannover Department of Pharmacology, Toxicology and Pharmacy and Center for Systems Neuroscience, Bünteweg 2, 30559 Hannover, Germany
 
  #256 Can in vivo bioluminescence imaging in Dcx-Luc reporter mice assess neurogenesis in a chemically induced Parkinson’s disease mouse model?
Fricke Inga B1, Viel Thomas1,2, Hermann Sven1, Couillard-Després Sébastien3,4, Jacobs Andreas H.1,5
1Westfälische Wilhelms University Münster, European Institute for Molecular Imaging (EIMI) - Münster, Germany
2Université Paris Descartes, PARCC, Inserm UMR 970 - Paris, France
3Paracelsus Medical University, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS) - Salzburg, Austria
4Paracelsus Medical University, Institute of Experimental Neuroregeneration - Salzburg, Austria
5Johanniter Hospital, Evangelische Kliniken, Department of Geriatrics - Bonn, Germany
 
  #257 Imaging of brain TSPO expression with [18F]DPA-714 PET/CT and immunofluorescence analysis in mouse model of ALS
Anna Rita Daniela Coda 1, Sara Gargiulo 1,2, Serenella Anzilotti 3, Matteo Gramanzini 1,2, Adelaide Greco 4,2, Maria Rosaria Panico 1, Frederic Dollè 5, Giuseppe Pignataro 6, Mario Quarantelli 1, Lucio Annunziato 6,3, Arturo Brunetti 4, Marco Salvatore 3, Sabina Pappatà 1
1Institute of Biostructure and Bioimaging, CNR, Via T. De Amicis, 95, 80145 Naples, Italy
2Ceinge, Biotecnologie Avanzate, scarl, Via G. Salvatore, 486, 80146 Naples, Italy
3IRCCS SDN, Via E. Gianturco, 113, 80143 Naples, Italy
4University Federico II Department of Advanced Biomedical Sciences, Via Pansini, 5, 80145 Naples, Italy
5CEA, Institute for Biomedical Imaging, 4 Place du Général Leclerc, 91401 Orsay, France
6University Federico II Department of Neuroscience, Reproductive and Dentistry Sciences, Via Pansini, 5, 80145 Naples, Italy
 
  #258 Focal glucose hypo-metabolism in chronically epileptic rats extends to protein hypo-metabolism, measured by F-18-FDG and F-18-FET PET.
Bankstahl Jens P.1, Bascunana Almarcha Pablo1, Leiter Ina1,2, Bengel Frank M.1, Bankstahl Marion2
1Hannover Medical School, Nuclear Medicine - Hannover, Germany
2Veterinary University Hannover, Pharmacology - Hannover, Germany
 
  #259 Brain energy metabolism and neuroinflammation in Alzheimer’s disease: Longitudinal 18F-FDG and 18F-DPA-714 PET imaging study with APP/PS1-21 mice
Jatta S. Takkinen 1, Francisco R. López-Picón 1, Tomas Keller 2, Anna Krzyczmonik 2, Olli Eskola 2, Olof Solin 2,3, Juha O. Rinne 2,4, Merja Haaparanta-Solin 1
1University of Turku Medicity/PET Preclinical Laboratory, Tykistokatu 6 A, FI-20520 Turku, Finland
2University of Turku Turku PET Centre, Kiinamyllynkatu 4-8, FI-20520 Turku, Finland
3Abo Akademi University Turku PET Centre, Kiinamyllynkatu 4-8, FI-20520 Turku, Finland
4Turku University Hospital Turku PET Centre, Kiinamyllynkatu 4-8, FI-20520 Turku, Finland
 
  #260 Characterization of motor deficits on rats with corticostriatal strokes using behavioral assessments in combination with multiparametric MRI
Kristin Patzwaldt , Hanna Napieczynska , Carsten Calaminus , Bernd J. Pichler , Salvador Castaneda Vega
Werner Siemens Imaging Center Department of Preclinical Imaging and Radiopharmacy, Eberhart Karls University Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany
 
  #261 In vivo quantification of dopaminergic terminals loss in Parkinson’s Disease rat with AAV-induced overexpression of alpha-synuclein: a [18F]FMT microPET study.
Guillaume Becker 1, Mohamed Ali Bahri 1, Anne Michel 2, Fabian Hustadt 2, Andre Luxen 1, Gaëtan Garraux 1, Christian Lemaire 1, Alain Plenevaux 1
1University of Liege Cyclotron Research Center, allee du six Aout, 4000 Liege, Belgium
2UCB Pharma SPRL Parkinson’s disease group, Braine L’Alleud, Belgium
 
  #262 EVALUATION OF SV2Alox/Cre TRANSGENIC MICE USING [18F]UCB-H IN IN VITRO AUTORADIOGRAPHY
Serrano Marie Elisa1, Becker G.1, Menten C.2, Bahri Mohamed Ali1, Warnier Corentin1, Mievis F.1, Giacomelli F.1, Lemaire Christian1, Salmon E.1, Luxen Andre1, Rogister B.2, Plenevaux Alain1
1University of Liège, Cyclotron Research Center - Liège, Belgium
2University of Liège, GIGA Neurosciences - Liège, Belgium
 
  #263 Polymeric micelle MRI contrast agent exhibits hyper-permeable BBB in ischemic stroke-reperfusion injury
Kouichi Shiraishi , Zuojung Wang , Masayuki Yokoyama
The Jikei University School of Medicine Research Center for Medicinal Sciences, 3-25-8, Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan
 
  #264 In vivo comparison of tau-specific radioligands in the normal rat brain and in various rat models of sporadic and familial tauopathy using PET imaging
Nadja van Camp 1,2, Elsa Diguet 3, Dimitri Cheramy 3, Karine Cambon 1,2, Mylène Guérif 3, Léopold Eymin 1,2, Yann Bramoulle 1,2, Marie D'orange 1,2, Martine Guillermier 1,2, Gwennaëlle Auregan 1,2, Charlène Josephine 1,2, Noelle Dufour 1,2, Marie-Claude Gaillard 1,2, Anne-Marie Chollet 3, Alexis Bemelmans 1,2, Philippe Hantraye 1,2
1Molecular Imaging Research Center (MIRCen, I²BM) Department of Fundamental Sciences, Fontenay aux Roses, France
2UMR9199, Centre National de la Recherche Scientifique (CNRS) Université Paris-Sud, Université Paris-Saclay, Fontenay aux Roses, France
3Institut de Recherches Servier DRD-RDNPS, Croissy sur Seine, France
 
  #265 Visualizing molecular events after mouse brain ischemic lesion by in vivo bioluminescence imaging
Srecko Gajovic 1, Dora Polšek 1, Dunja Gorup 1, Jasna Kriz 2, Dinko Mitrečić 1
1University of Zagreb School of Medicine Croatian Institute for Brain Research, Salata 12, 10000 Zagreb, Croatia
2Laval University Faculty of Medicine Dpt. of Psychiatry and Neuroscience, Quebec Quebec Canada
 
  #266 Diffusion Kurtosis Imaging identifies early Alzheimer’s pathology in the APP/PS1 amyloidosis mouse model.
Jelle Praet 1, Leacky Muchene 2, Nikolay Manyakov 3, Zhenhua Mai 1, Vasilis Terzopoulos 4, Steve de Backer 5, An Torremans 6, Pieter-Jan Guns 1, Tom van de Casteele 3, Astrid Bottelbergs 3, Bianca van Broeck 3, Jan Sijbers 7, Dirk Smeets 4, Ziv Shkedy 2, Luc Bijnens 1,3, Darrel Pemberton 3, Mark Schmidt 3, Marleen Verhoye 1, Annemie van der Linden 1
1Universiteit Antwerpen FBD/Bio-Imaging Lab, Universiteitsplein 1, 2610 Wilrijk, Belgium
2UHasselt Science/Mathematics and statistics, Agoralaan - Building D, 3590 Diepenbeek, Belgium
3Janssen Pharmaceutica Discovery Sciences, Turnhoutseweg 30, 2340 Beerse, Belgium
4Icometrix, Tervuursesteenweg 244, 3001 Leuven, Belgium
5DCI Labs, Mwami Mutaradreef 18, 3140 Keerbergen, Belgium
6HistoGeneX, Lindendreef 1, 2020 Antwerpen, Belgium
7Universiteit Antwerpen Physics/Vision Lab, Universiteitsplein 1, 2610 Wilrijk, Belgium
 


 

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