Synthesis and characterization of a superparamagnetic iron oxide nanoparticle (SPION) coated with citric acid for MR imaging: effect of time and temperature Seyed Mohammadali Dadfar, Nihan Güvener, Josbart Metselaar, Srinivas Banala, Fabian Kiessling, Twan Lammers
Uniklinik RWTH Aachen Department of Experimental Molecular Imaging, Pauwelsstrasse 30, 52074 Aachen, Germany
#18
Tumor targeting with multimeric MRI contrast agents Martinelli Jonathan 1, Tei Lorenzo 2, Botta Mauro 2, Djanashvili Kristina 1 1Delft University of Technology Department of Biotechnology, Julianalaan 136, 2628BL Delft, Netherlands 2Universitŕ del Piemonte Orientale Department of Science and Technological Innovation, Viale Michel 11, 15121 Alessandria, Italy
#19
Host-guest systems in aqueous solutions as a platform for 19F molecular MR imaging
Liat Avram-Biton 1, Mark Iron 1, Amnon Bar-Shir 2 1Weizmann Institute of Science Department of Chemical Research Support, 234 Herzl, 76100 Rehovot, Israel 2Weizmann Institute of Science Department of Organic Chemistry, 234 Herzl, 76100 Rehovot, Israel
#20
Fibrin/Fibronectin complex as extracellular imaging biomarker of Prostate Adenocarcinoma Amerigo Pagoto, Rachele Stefania, Enza di Gregorio, Francesca Arena, Silvio Aime, Enzo Terreno
University of Torino Department of Molecular Biotechnology and Health Sciences, Via Nizza 52, 10126 Torino, Italy
#21
Rational Design of Fluorocarbon-loaded Polymeric Nanoparticles for Cell Tracking Using Multimodal In Vivo Imaging
Olga Koshkina, Edyta Swider, Eric van Dinther, Carl Figdor, Jolanda de Vries, Mangala Srinivas
Radboud University Medical Center Tumor Immunology, Radboud Institute for Molecular Life Sciences (RIMLS), 6500HB Nijmegen, Netherlands
#22
Glioblastoma pH mapping by using Yb-HPDO3A CEST MRI probe Giuseppe Ferrauto 1, Michel Sarraf 2, Enza di Gregorio 1, Ulysse Gimenez 2, Vincent Auboiroux 3, Francois Berger 2, Silvio Aime 1, Hana Lahrech 2 1Molecular Imaging Center-University of TORINO Molecular Biotechnologies & Health Sciences, Via Nizza 52, 10126 Torino, Italy 2CLINATEC Translational Technology Laboratory INSERM U1205 – CHU –UJF, Campus Minatec, 17 avenue des Martyrs, 38054 Grenoble, France 3CLINATEC – CEA- Grenoble, Campus Minatec, 17 avenue des Martyrs, 38054 Grenoble, France
#23
Insights on the main determinants of LipoCEST effect: modulation of intraliposomal water chemical shift and Water Exchange Rate Giuseppe Ferrauto, Enza di Gregorio, Silvio Aime
Molecular Imaging Center-University of TORINO Molecular Biotechnologies & Health Sciences, Via Nizza 52, 10126 Torino, Italy
#24
In vivo Manganese enhanced Magnetic Resonance imaging (MEMRI)as new tool to evaluate bone formation Francesca Rosa, Luca Basso, Romina Saporiti, Ilaria Verardo, Daniele Pace, Carlo Emanuele Neumaier
IST-IRCCS San Martino Hospital Radiology, largo R. Benzi, 16143 Genova, Italy
#25
New biocompatible nanohydrogels to obtain highly efficient MRI Gd contrast agents
Maité Callewaert1, Guillaume Rigaux1, Yasmina Belabassi1, Cyril Cadiou1, Juliette Moreau1, Maxime Ewald2, Michael Molinari2, Christophe Portefaix3, Céline Henoumont4, Luce Vander Elst4, Muller Robert4,5,4, Benoit Baudouin5, Sebastien Boutry4, Anca Dinischiotu6, Françoise Chuburu1, Sophie Laurent4,5 1URCA, ICMR, CNRS UMR 7312 - Reims, France 2URCA, LRN, EA 4682, - Reims, France 3CHU de Reims, Radiology Department - Reims, France 4University of Mons - MONS, Belgium 5Center for Microscopy and Molecular Imaging - Charleroi-Gosselies, Belgium 6Biochemistry and Molecular Biology Department - Bucharest, Romania
#26
Design of theranostic PLGA-based nanoparticles loaded with MRI imaging agents and boron/curcumin adducts to combine Boron Neutron Capture Therapy (BNCT) and chemotherapy Diego Alberti 1, Morgane Franck 1, Rachele Stefania 1, Silva Bortolussi 2, Nicoletta Protti 2, Saverio Altieri 2, Annamaria Deagostino 3, Simonetta Geninatti Crich 1, Silvio Aime 1 1University of Torino Department of Molecular Biotechnology and Health Sciences, via Nizza 52, 10126 Torino, Italy 2University of Pavia Department of Physics, via Bassi 6, 27100 Pavia, Italy 3University of Torino Department of Chemistry, via Giuria 7, 10125 Torino, Italy
#27
Imaging of glycosylation in vivo using metabolic labeling and MRI. Neves Andre1, Wainman Yéléna1,2, Wright Alan1, Kettunen Mikko1,3, Rodrigues Tiago1, McGuire Sarah1, Hu De-En1, Bulat Flaviu2,2, Geninatti Crich Simonetta4, Leeper Finian2, Brindle Kevin1 1CRUK Cambridge Institute, Li Ka Shing Centre - Cambridge, United Kingdom 2University of Cambridge, Chemistry - Cambridge, United Kingdom 3University of Eastern Finland, A. I. Virtanen Institute for Molecular Sciences - Kuopio, Finland 4Molecular Imaging Center, Department of Molecular Biotechnology and Health Science - Turin, Italy
#28
Optimization of parameters for monodisperse Fe2O3 nanoparticles suitable for Magnetic Particle Imaging Srinivas Banala 1,2, Katharina Schmitz 2, Marcel Straub 1, Volkmar Schulz 1, Mareike Hoss 1, Magnus Rueping 2, Fabian Kiessling 1 1UniKlinik Aachen, Pauwelstrasse 20,, 52074 Aachen, Germany 2Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen, Germany
#29
PEGylation effects on relaxivity properties of Gd-loaded Nanozeolite LTL as a potential pH-responsive probe for MRI
Wuyuan Zhang 1, Jonathan Martinelli 1, Joop A. Peters 1, Célia S. Bonnet 2, Frédéric Szeremeta 2, Kristina Djanashvili 1 1Delft University of Technology Biotechnology, Julianalaan 136, 2628 BL Delft, Netherlands 2CNRS Centre de Biophysique Moléculaire, Rue Charles Sadron, 45071 Orléans Cedex 2, France
#30
Multiparametric characterization of murine Prostate Cancers by MRI di Gregorio Enza1, Ferrauto Giuseppe1, Lanzardo Stefania 1, Iezzi Manuela 2, Gianolio Eliana 1, Aime Silvio 1 1Molecular Imaging Center-University of TORINO Molecular Biotechnologies & Health Sciences - Torino, Italy 2Universitŕ degli Studi "G. d'Annunzio" DIPARTIMENTO DI MEDICINA E SCIENZE DELL'INVECCHIAMENTO - Chieti, Italy
#31
External magnetic navigation of iron-oxide laden cells – proof-of-concept as a prerequisite for magnetic drug targeting Michael Bietenbeck 1,2, Sandra Gran 3, Verena Hoerr 2, Johannes Roth 3, Cornelius Faber 2, Ali Yilmaz 1 1University Hospital Münster Deparment of Cardiology and Angiology, Albert-Schweitzer-Campus 1, 48149 Münster, Germany 2University Hospital Münster Institute of Clinical Radiology, Translational Research Imaging Center, Albert-Schweitzer-Campus 1, 48149 Münster, Germany 3University Hospital Münster Institute of Immunology, Röntgenstraße 21, 48149 Münster, Germany
#32
Tailored Colloidal Nanocrystal Clusters for Diagnosis and Therapy
Athanasia Kostopoulou 1, Konstantinos Brintakis 1,2, Alexandros Lappas 1, Giannis Zacharakis 1 1Foundation for Research and Technology - Hellas (FORTH) Institute of Electronic Structure and Laser (IESL), Vassilika Vouton, 71110 Heraklion, Greece 2Aristotle University of Thessaloniki Department of Physics, 54124 Thessaloniki, Greece
#33
Fluorine Labels for 19F Magnetic Resonace Imaging
Olatz Mitxelena 1, Jorge Blanco 1, Daniel Padró 1, Pablo Del Pino 1, Wolfgang J. Parak 1, Mónica Carril 1,2 1CIC biomaGUNE, 20009 San Sebastian, Spain 2Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain
#34
Polysiloxane coated nanoparticles, an innovative platform for pre-clinical MRI Sophie Laurent1,2, Dimitri Stanicki1, Sebastien Boutry2, Lionel Larbanoix2, Luce Vander Elst1,2, Muller Robert1,2 1University of Mons - MONS, Belgium 2Center for Microscopy and Molecular Imaging - Charleroi-Gosselies, Belgium
High rate tests on SiPM readout ASICs for the SAFIR project Chiara Casella
ETH Zurich IPP (Institute Particle Physics), Otto-Stern-Weg 5, 8093 Zurich, Switzerland
#96
Accuracy and reproducibility of PET derived [18F]FDG concentrations in the rat brain Marc Huisman 1, Emerson Itikawa 1,2, Ricardo Vos 1, Mariska Verlaan 1, Eline Elshof 1, Julia Mannheim 3, Adriaan Lammertsma 1, Guus van Dongen 1, Carla Molthoff 1 1VU University Medical Center Radiology and Nuclear Medicine, 1007 MB Amsterdam, Netherlands 2Ribeirăo Preto School of Medicine, Ribeirăo Preto, Brazil 3Labor für Präklinische Bildgebung und Bildgebungstechnologie der Werner Siemens-Stiftung, Tubingen, Germany
#97
Synchrotron Radiation Computed Tomography for functional and morphological studies in pre-clinical research: focus on lungs imaging
Christian Dullin 1, Simeone Dal Monego 2, Emanuel Larsson 3,4,5, Sara Mohammadi 6, Martin Krenkel 7, Chiara Garrovo 8, Stefania Biffi 8, Andrea Lorenzon 2, Andrea Markus 9, Joanna Napp 9,10,1, Tim Salditt 7, Jennine Missbach-Günther 1, Agostino Accardo 4, Frauke Alves 9,10,1, Giuliana Tromba 3 1University Medical Center Goettingen Dept. of Diagnostic and Interventional Radiology, Robert Koch Str. 40, 37075 Göttingen, Germany 2Cluster in Biomedicine, AREA Science Park, 34149 Basovizza (Trieste), Italy 3Elettra-Sincrotrone Trieste, Strada Statale 14, km 163.5 in AREA Science Park, 34149 Basovizza (Trieste), Italy 4University of Trieste Department of Architecture and Engineering, Piazzale Europa 1, 34127 Trieste, Italy 5Linköping University Department of Physics, Chemistry and Biology, 83 Linköping, SE-58 Linköping, Sweden 6LAC + USC Medical Center, 2051 Marengo St, Los Angeles, CA 90033, United States 7University of Göttingen Institute for X-ray Physics, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany 8Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell'Istria, 65, 34137 Trieste, Italy 9University Medical Center Göttingen Department of Haematology and Medical Oncology, Robert Koch Str. 40, 37075 Göttingen, Germany 10Max Planck Institute for Experimental Medicine Molecular Biology of Neuronal Signals, Hermann-Rein-Str. 3, 37075 Göttingen, Germany
#98
Knowledge of magnetic nanoparticle distribution using microCT-imaging if beneficial for the treatment of tumors in mice via magnetic hyperthermia
Heidi Dähring, Julia Grandke, Ulf Teichgräber, Ingrid Hilger
University Hospital Jena Experimental Radiology, Erlanger Allee 101, 07747 Jena, Germany
#99
Quantitative Assessment of MicroCT Indexes in Mice with Bleomycin-Induced Lung Injury. Fabio Stellari 1, Yanto Ridwan 2, Paula van Heiningen 2, Sasha Belenkov 3, Jeroen Essers 2, Francesca Ruscitti 4, Francesca Ravanetti 5, Gino Villetti 1 1chiesi Corporate Pre-Clinical R&D, lago Belloli, 43123 Parma, Italy 2ERASMUS Genetics, Department of Vascular Surgery and Department of Radiation Oncology, Rotterdam, Netherlands 3PerkinElmer, Inc PerkinElmer, Inc, Waltham, MA United States 4Universitá di Parma Dipartimento di Scienze Biomediche, Biotecnologiche e Traslazionali, parma, Italy 5Universitá di Parma Dipartimento di Scienze Medico Veterinarie, Parma, Italy
#100
Evaluation of intra- and interpatient variability of cranial bone attenuation correction factors for brain PET/MR imaging Simone Beer, David Elmenhorst, Tina Kroll, Andreas Bauer
Forschungszentrum Juelich Institute of Neuroscience and Medicine (INM-2), Leo-Brandt-Strasse, 52425 Jülich, Germany
#101
Development and validation of a new 62Cu/62Zn generator system and the radio-synthesis of 62Cu-ATSM Zilin Yu 1, David Parker 2, Antony Gee 1, Philip Blower 1,3 1King’s College London Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, London, SE1 7EH, United Kingdom 2University of Birmingham School of Physics and Astronomy, Birmingham, B15 2TT, United Kingdom 3King’s College London Division of Chemistry, London, SE1 4DB, United Kingdom
#102
Biodistribution and Imaging of 177Lu-labeled macrocyclic bisphosphonates Ralf Bergmann 1, Marian Meckel 2, Vojtěch Kubíček 3, Jens Pietzsch 1, Jörg Steinbach 1, Petr Hermann 3, Frank Rösch 2 1Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328 Dresden, Germany 2University Mainz Institute of Nuclear Chemistry, Fritz-Strassmann-Weg 2, 55128 Mainz, Germany 3Charles University in Prague Department of Inorganic Chemistry, Hlavova 2030/8, 12843 Prague, Czech Republic
#103
A new method for obtaining continuous Depth of Interaction (DOI) information with single side readout in PET scanners Marco Pizzichemi 1, Gianluca Stringhini 1,2, Tahereh Niknejad 3, Stefaan Tavernier 3,4, Joao Varela 3, Paul Lecoq 2, Marco Paganoni 1, Etiennette Auffray 2 1University of Milano-Bicocca Physics, Piazza della Scienza 3, 20126 Milano, Italy 2CERN, Geneve, Switzerland 3Laboratorio de Instrumentacao e Fisica Experimental de Particulas, Lisbon, Portugal 4Vrije Universiteit Brussel, Brussels, Belgium
#104
Pharmacokinetic analysis of dynamic PET data: comparison between direct parametric reconstruction and conventional indirect voxel-based estimation Michele Scipioni 1, Maria Filomena Santarelli 2,3, Assuero Giorgetti 3, Vincenzo Positano 3, Sabrina Fucci 3, Luigi Landini 1,3 1University of Pisa Information Engineering, via Caruso,16, 56122 Pisa, Italy 2CNR Institute of Clinical Physiology, via Moruzzi,1, 56124 Pisa, Italy 3Fondazione Toscana "G. Monasterio", via Moruzzi,1, 56124 Pisa, Italy
#105
Fully Automatic Analysis Tool for Dynamic Cardiac PET Studies Carlos Velasco 1,2, Jesús Mateo 1,2, Teresa Arias 1,2, Jesús Ruiz-Cabello 1,2, Samuel Espańa 1,2 1Centro Nacional de Investigaciones Cardiovasculares Advanced Imaging Unit, Melchor Fernández Almagro, 28029 Madrid, Spain 2CIBER de Enfermedades Respiratorias (CIBERES), Monforte de Lemos, 3-5, 28029 Madrid, Spain
#106
Analysis of dermal collagen composition by Small Angle X-ray scattering (SAXS) and Atomic force microscopy (AFM) in genetically modified mice Jeannine Missbach-Guentner 1,2, Sigrid Bernstorff 3, Thilo Baronsky 4, Andreas Janshoff 4, Frauke Alves 1,2,5, Christian Dullin 1 1University Medical Center Goettingen Dept. of Diagnostic and Interventional Radiology, Robert-Koch-Str. 40, 37075 Goettingen, Germany 2University Medical Center Goettingen Dept. of Haematology and Medical Oncology, Robert-Koch-Str. 40, 37075 Goettingen, Germany 3Elettra Synchrotron Group Spectroscopy/ Scattering beamlines, Strada Statale 14 - km 163,5, 34149 Basovizza, Italy 4University Goettingen Institute for Physical Chemistry, Tammannstr.6, 37077 Goettingen, Germany 5Max Planck Institute for Experimental Medicine Dept. of Molecular Biology of Neuronal Signals, Herrmann-Rein-Str2, 37075 Goettingen, Germany
#107
Longitudinal micro-computed tomography-derived biomarkers for lung metastasis detection in a preclinical mouse model: added value to bioluminescence imaging
Eyra Marien 1, Amy Hillen 2, Johannes V. Swinnen 1, Greetje Vande Velde 2 1University of Leuven - KU Leuven Department of Oncology - Lab of Lipid Metabolism and cancer, Herestraat 49 – box 902, 3000 Leuven, Belgium 2University of Leuven - KU Leuven Department of Imaging and Pathology - Biomedical MRI, Herestraat 49 – box 505, 3000 Leuven, Belgium
#108
Characterization of the imaging performance of a micro-CT system based on the photon counting XPAD3/Si hybrid pixel detectors Franca Cassol 1, Mathieu Dupont 1, Carine Kronland-Martinet 1, Hamid Ouamara 2, Arkadiusz Dawiec 3, Yannick Boursier 1, Alain Bonissent 1, Jean-Claude Clémens 1, Loriane Portal 1, Franck Debarbieux 4, Christian Morel 1 1Aix Marseille Université, CNRS/IN2P3, CPPM UMR 7346, 13288, Marseille, France 2EOS imaging, Paris, France 3Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin BP 48 91192,, Gif-sur-Yvette, France 4Aix Marseille Université, CNRS INT, UMR 7289, Marseille, France
#109
Performance evaluation of “γ-eye” benchtop camera for scintigraphic mouse imaging
Maria Georgiou 1, Panagiotis Papadimitroulas 1, Eleftherios Fysikopoulos 1, Konstantinos Mikropoulos 1, George Loudos 2 1BET Solutions R & D, Alexandras Avenue 116, 11472 Athens, Greece 2Technological Educational Institute of Athens Biomedical Engineering, Ag. Spiridonos 28, 12210 Athens, Greece
#110
Generation and validation of image-derived input functions from rodents using a dynamic 3D printed phantom Marie-Claude Asselin 1, Gabrielle Baxter 2, Archie Skone 2, Jack Kennedy 2, George Ralli 2, Hervé Boutin 1 1The University of Manchester Wolfson Molecular Imaging Centre, 27 Palatine Road, Manchester, M20 3LJ, United Kingdom 2The University of Manchester School of Physics and Astronomy, Manchester, United Kingdom
#111
Novel technique for repeated arterial blood sampling in small animals: Application in a test-retest study with an adenosine A1 receptor ligand and positron emission tomography Sijbesma Jürgen1, Zhou Xiaoyun 1, Vállez Garcia David 1, Houwertjes Martin 2, Doorduin Janine 1, Kwizera Chantal 1, Maas Bram 1, Meerlo Peter 3, Dierckx Rudi1, Slart Riemer 1, Elsinga Philip H. 1, van Waarde Aren 1 1University of Groningen, University Medical Center Groningen Nuclear Medicine and Molecular Imaging - Groningen, Netherlands 2University of Groningen, University Medical Center Groningen Experimental Anesthesiology - Groningen, Netherlands 3University of Groningen, Center for Behavior and Neurosciences Behavioral Physiology - Groningen, Netherlands
#112
Proof of Principle of a Custom-Made γ-Ray Coincidence Counter for Analysis of Cardiac PET Tracer Kinetics on Isolated Perfused Rat Hearts Ian Somlai-Schweiger, Marie Bieth, Sybille Reder, Stephan G. Nekolla, Sibylle I. Ziegler, Markus Schwaiger
Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany
#113
Reading thousands of SiPMs in Nuclear medicine applications with excellent Time resolution.
Tahereh Niknejad, Ricardo Bugalho, Agostino di Francerso, Luis Ferramacho, Carlos Leong, Jose Carlos Rasteiro da Silva, Manuel Rolo, Rui Silva, Stefaan Tavernier, Varela Joăo, Miguel Silveira
Inst. Superior Tecnico LIP, R. Professor Anibal Cavaco Silva, 26, 2740-122 Oeiras, Portugal
#114
3D brain reconstructions from serial autoradiographic sections Fabien Chauveau 1, Gaëlle Emvalomenos 2, Mathieu Verdurand 1, Thierry Delzescaux 3, Luc Zimmer 1, Marie-Claude Gregoire 2, Anthonin Reilhac 1, Arnaud Charil 2 1University of Lyon, Lyon Neuroscience Research Center (CRNL); CNRS UMR5292; INSERM U1028; Univ. Lyon 1, Lyon, France 2Australian Nuclear Science and Technology Organisation (ANSTO) ANSTO LifeSciences, Lucas Heights Australia 3Molecular Imaging Research Center (MIRCen), CEA-I2BM; CNRS UMR9199, Fontenay-aux-Roses, France
#115
In vivo quantitative assessment of lung structural abnormalities and inflammation in small animal emphysema and fibrosis models using micro-computed and optical tomography. Jeroen Essers
Erasmus MC Genetics, Wytemaweg 80, 3015CN Rotterdam, Netherlands
In-vivo imaging of human intestinal perfusion and oxygen saturation in patients with Crohn’s disease using multispectral optoacoustic tomography Ferdinand Knieling 1,2, Stefan Morscher 3, Alexander Urich 3, Rüdiger Stephan Görtz 2, Cornelia Egger 2, Alexander Hagel 2, Dane Wildner 2, Marcel Vetter 2, Christian Kielisch 2, Deike Strobel 2, Raja Atreya 2, Markus Neurath 2, Maximilian Waldner 1,4 1Friedrich-Alexander Universität Erlangen-Nürnberg Clinic for Children and Youth, Loschgestr. 15, 91054 Erlangen, Germany 2Friedrich-Alexander Universität Erlangen-Nürnberg Medical Department 1, Ulmenweg 18, 91054 Erlangen, Germany 3iThera Medical, Zielstattstraße 13, 81379 München, Germany 4Friedrich-Alexander Universität Erlangen-Nürnberg Erlangen Graduate School in Advanced Optical Technologies (SAOT), Paul-Gordan-Straße 6, 91052 Erlangen, Germany
#117
Indocyanine Green clearance measurement by means of Multispectral Optoacoustic Tomography correlates with liver function impairment in APAP-induced liver injury mice Nathalie Brillant 1, Jack Sharkey 1, Neal Burton 2, Dan Antoine 1 1University of Liverpool Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, Sherrington Building, Liverpool, L693GE, United Kingdom 2iThera Medical, Zielstattstrasse 13, 81379 Munich, Germany
#118
3D Photoacoustic Microscopy for Cell Tracking
Po-Yi Lee 1, Wei-Wen Liu 1, Shu-Ching Chen 2, Pai-Chi Li 1, Tseng Linyi 3, Cao Liji 3 1National Taiwan University Graduate Institute of Biomedical Electronics and Bioinformatics, Taipei 106 Taiwan 2National Taiwan University Hospital Internal Medicine, Taipei 100 Taiwan 3S-Sharp Corporation, Beixin Road, New Taipei City 231 Taiwan
#119
Towards quantitative photoacoustic tomography by acousto-optically measured light fluence Altaf Hussain, Wiendelt Steenbergen
Biomedical Photonic Imaging group, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE ENSCHEDE, Netherlands
#120
Multispectral photoacoustic imaging of tumors in vivo Jonathan Lavaud 1,2,3, Maxime Henry 1,2,3, Pascal Gayet 4, Jean-Luc Coll 1,2,3, Véronique Josserand 1,2,3 1INSERM U823, Institut Albert Bonniot Targeted Therapy, Early Diagnostic, Cancer Imaging, 38000 Grenoble, France 2Univ. Grenoble Alpes, Institut Albert Bonniot Targeted Therapy, Early Diagnostic, Cancer Imaging, 38000 Grenoble, France 3OPTIMAL small animal imaging facility, 38000 Grenoble, France 4Fluoptics, 38000 Grenoble, France
#121
Sensitivity and reproducibility of multispectral optoacoustic tomography for deep tissue non-invasive imaging James Joseph 1,2, Michal Tomaszewski 1,2, Isabel Quirós-Gonzalez 2, Judith Weber 2,1, Sarah Bohndiek 1,2 1University of Cambridge Physics, JJ Thomson Avenue, Cambridge, CB30HE, United Kingdom 2University of Cambridge Cancer Research UK Cambridge Institute, Li Ka Shing Center, Robinson Way, Cambridge, CB2 0RE, United Kingdom
#122
Monitoring shock wave ablation using high frequency ultrasound and photoacoustics Khalid Daoudi 1, Martijn Hoogenboom 2, Jurgen Fütterer 2, Chris de Korte 1 1Radboud University Nijmegen Medical Centre Department of Radiology and Nuclear Medicine, Medical UltraSound Imaging Centre (MUSIC), Nijmegen, Netherlands 2Radboud University Nijmegen Medical Centre Department of Radiology, Nijmegen, Netherlands
#123
Positron Emission Tomography registered Ultrafast Sonography: qualification of the PETRUS prototype Anikitos Garofalakis 1, Jean Provost 2, Thomas Viel 1,3, Damien Bouda 1, Prashanth Kumar Vaddeboina 1, Geert Leenders 1, Mickael Tanter 2, Bertrand Tavitian 1,3,4 1INSERM UMR 970, Paris Cardiovascular Research Center, 56, rue Leblanc, 75015 Paris, France 2Institut Langevin, ESPCI ParisTech, INSERM U979, CNRS UMR 7587, 1 rue Jussieu, France, 75238 Paris Cedex 05, France 3Université Paris Descartes, Sorbonne Paris Cité, Paris, France 4Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Radiology Department, Paris, France
#124
In vivo characterization of tumor heterogeneity under antiangiogenic and cytotoxic therapy using ultrasonography modalities: Shear Wave Elastography (SWE), Contrast Enhanced Ultrasound (CEUS) and Quantitative Ultrasound (QUS) Alexandre Dizeux 1, Thomas Payen 1, Guillaume Barrois 1, Michele Lamuraglia 1,2, Capucine Baldini 1, Delphine Le Guillou 1, Eva Comperat 3, Michael Oelze 4, Jean-Luc Gennisson 5, Mickael Tanter 5, S. Lori Bridal 1 1Laboratoire d’Imagerie Biomédicale UPMC, CNRS UMR7371, INSERM U1146 75, 15 rue de l'école de médecine, 75006 Paris, France 2Service d’Oncologie, Departement de Medecine Interne, APHP Louis-Mourier, Colombes, France 3Central Department of Pathological Anatomy and Cytology, GH Pitié-Salpętričre, AP-HP, Paris, France 4Electrical and Computer Engineering Department at the University of Illinois, Urbana, IL 61801, United States 5Institut Langevin ESPCI ParisTech, CNRS UMR7587, INSERM U979, Paris, France
#125
Evaluation of time intensity curve based parametric maps for the characterization of tumors with ultrasound imaging
Benjamin Theek 1, Tatjana Opacic 1, Dimitri Ackermann 2, Georg Schmitz 2, Fabian Kiessling 1 1RWTH Aachen University Clinic and Helmholtz Institute for Biomedical Engineering Department of Experimental Molecular Imaging, Pauwelsstr. 30, 52074 Aachen, Germany 2Ruhr-University Bochum Department of Medical Engineering, Universitätsstr. 150, 44801 Bochum, Germany
#126
Polymeric nanoparticles for enhancing HIFU ablation Edyta Swider 1, Dylan Eikelenboom 1, Martijn Hoogenboom 2, Olga Koshkina 1, Jurgen Futterer 2, Gosse Adema 1, Mangala Srinivas 1 1Radboud Institute for Molecular Life Sciences Department of Tumor Immunology, Geert Grooteplein 26-28, 6525 GA Nijmegen, Netherlands 2Radboud University Medical Center Department of Radiology and Nuclear Medicine, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, Netherlands
#127
A new High Frequency Ultrasound guided Orthotopic mouse model of Thyroid Carcinoma.
Luigi Auletta 1, Sandra Albanese 2,3, Antonella Zannetti 4, Peppino Mirabelli 1, Crescenzo D'alterio 5, Andrea Soricelli 1,6, Marco Salvatore 1, Adelaide Greco 2,3,4 1IRCCS SDN, Napoli, Italy 2Universitŕ degli studi di Napoli Federico II Dipartimento di Scienze Biomediche Avanzate, Napoli, Italy 3CEINGE Biotecnologie Avanzate, scarl, Napoli, Italy 4IBB CNR, Napoli, Italy 5Fondazione G. Pascale, IRCCS National Cancer Institute, Napoli, Italy 6Universitŕ Parthenope Dipartimento di Scienze Motorie e del Benessere, Napoli, Italy
#128
In-vitro optimisation of sonoporation conditions for a pancreatic cancer cell line in hypoxic conditions
Endre Stigen 1,2, Spiros Kotopoulis 2,3,4, Bjřrn Tore Gjertsen 5,6, Odd Helge Gilja 2,3, Emmet Mc Cormack 1,6 1University of Bergen Department of Clinical Science, Jonas Lies veg 87, 5021 Bergen, Norway 2Haukeland University Hospital National Centre for Ultrasound in Gastroenterology, Postboks 7804, 5020 Bergen, Norway 3University of Bergen Department of Clinical Medicine, Postboks 7804, 5021 Bergen, Norway 4University of Bergen Department of Physics and Technology, Allegaten 55, 5007 Bergen, Norway 5University of Bergen Centre for Cancer Biomarkes, CCBIO, Postboks 7804, 5020 Bergen, Norway 6University of Bergen Department of Internal Medicine, Hematology Section, Haukeland University Hospital, 5021 Bergen, Norway
#129
Effect of nanoparticle size on the displacement signal in magnetomotive ultrasound imaging Roger Andersson 1, Maria Evertsson 1, Hanna Toftevall 2, Magnus Cinthio 1, Sarah Fredriksson 2, Tomas Jansson 3,4 1Biomedical Engineering Lund University, Lund, Sweden 2Genovis AB, Lund, Sweden 3Clinical Sciences Lund, Biomedical Engineering Lund University, Lund, Sweden 4Medical Services Skĺne University Hospital, Lund, Sweden
Molecular-guided fluorescence endoscopy for colorectal polyp identification: a dose-escalation study with bevacizumab-800CW Tjalma Jolien1, Hartmans Elmire1, Garcia-Allende Beatriz2, Linssen Matthijs D.3, Koller Marjory4, Jorritsma-Smit Annelies3, E Silva de Oliveira Nery Mariana1, Karrenbeld Arend5, Kleibeuker Jan1, van Dam Gooitzen M.4, Robinson Dominic6, Ntziachristos Vasilis2, Nagengast Wouter1 1University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology - Groningen, Netherlands 2Technical University of Munich and Helmholtz Center Munich, Chair for Biological Imaging & Institute for Biological and Medical Imaging - Munich, Germany 3University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology - Groningen, Netherlands 4University of Groningen, University Medical Center Groningen, Department of Surgery - Groningen, Netherlands 5University of Groningen, University Medical Center Groningen, Department of Pathology - groningen, Netherlands 6Erasmus MC, Center for Optical Diagnostics and Therapy Department of Otolaryngology and Head & Neck Surgery - Rotterdam, Netherlands
#132
The added value of fluorescence imaging during laparoscopic resection of liver tumors Henricus Handgraaf 1, Leonora Boogerd 1, Hwai-Ding Lam 1, Volkert Huurman 1, John Frangioni 2,3,4, Cornelis van de Velde 1, Andries Braat 1, Alexander Vahrmeijer 1 1Leiden University Medical Center Surgery, Albinusdreef 2, Leiden, Netherlands 2Beth Israel Deaconess Medical Center Division of Hematology/Oncology, Department of Radiology, Boston, Massachusetts 02215, United States 3Beth Israel Deaconess Medical Center Department of Medicine, Boston, Massachusetts 02215, United States 4Curadel, LLC, Worcester, Massachusetts 01605, United States
#133
Visualization of Esophageal Adenocarcinoma with VEGF-targeted Near-infrared Molecular Fluorescence Endoscopy Elmire Hartmans1, Garcia-Allende Beatriz2, Peters Frans T.1, Koller Marjory3, Tjalma Jolien1, Linssen Matthijs D.4, Jorritsma-Smit Annelies4, Karrenbeld Arend5, Kleibeuker Jan1, van Dam Gooitzen M.6, Ntziachristos Vasilis2 1University Medical Center Groningen, Gastroenterology and Hepatology - Groningen, Netherlands 2Technical University of Munich and Helmholtz Center Munich, Chair for Biological Imaging & Institute for Biological and Medical Imaging - Munich, Germany 3University Medical Center Groningen, Surgery - Groningen, Netherlands 4University Medical Center Groningen, Clinical Pharmacy and Pharmacology - Groningen, Netherlands 5University Medical Center Groningen, Pathology - Groningen, Netherlands 6University Medical Center Groningen, Surgery, Nuclear Medicine and Molecular Imaging and Intensive Care - Groningen, Netherlands
#134
The integration of single fiber reflectance spectroscopy during endoscopic ultrasound-guided fine needle aspirations in pancreatic masses: a feasibility study Leonora Boogerd 1, Paulien Stegehuis 2, Akin Inderson 3, Roeland Veenendaal 3, Jouke Dijkstra 2, Arjen Amelink 4, Bert Bonsing 1, Cornelis van de Velde 1, Alexander Vahrmeijer 1, Dominic Robinson 5 1Leiden University Medical Center Surgery, Albinusdreef 2, 2333ZA Leiden, Netherlands 2Leiden University Medical Center Division of Image Processing, Department of Radiology, Albinusdreef 2, 2333ZA Leiden, Netherlands 3Leiden University Medical Center Gastroenterology, Albinusdreef 2, 2333ZA Leiden, Netherlands 4Erasmus Medical Center Center for Optical Diagnostics and Therapy, Department of Dermatology, 3000CA Rotterdam, Netherlands 5Erasmus Medical Center Center for Optical Diagnostics and Therapy, Department of Otolaryngology, Head and Neck Surgery, 3000CA Rotterdam, Netherlands
#135
Parameters affecting the detection of photons with digital silicon photomultipliers for Cherenkov luminescence imaging Esther Ciarrocchi 1,2, Nicola Belcari 1,2, Alberto Del Guerra 1,2, Matteo Morrocchi 1,2, Adrienne Lehnert 3, William C J Hunter 3, Robert S Miyaoka 3, Paul E Kinahan 3 1University of Pisa Department of Physics, Largo Bruno Pontecorvo 3, 56127 Pisa, Italy 2INFN Section of Pisa, Largo Bruno Pontecorvo 3, 56127 Pisa, Italy 3University of Washington Department of Radiology, Portage Bay Building, 1715 NE Columbia Road, Seattle, Washington State 98195-7987, United States
#136
In-vivo fluorescence lifetime imaging to differentiate bound from unbound cRGD-coupled NIR tracers Paulien Stegehuis 1,2, Mark Boonstra 1, Karien de Rooij 2, Harald Homulle 3, Claudio Bruschini 4, Edoardo Charbon 4,3, Boudewijn Lelieveldt 5,2, Cornelis van de Velde 1, Alexander Vahrmeijer 1, Jouke Dijkstra 2, Martijn van de Giessen 2 1Leiden University Medical Center Surgery, Albinusdreef 2, 2333ZA Leiden, Netherlands 2Leiden University Medical Center Radiology, Albinusdreef 2, 2333ZA Leiden, Netherlands 3Delft University of Technology, Stevinweg 1, Delft, Netherlands 4Ecole Polytechnique Fédérale de Lausanne, Route Cantonale, Lausanne, Switzerland 5Leiden University Medical Center Division of Image Processing, Department of Radiology, Albinusdreef 2, 2333ZA Leiden, Netherlands
#137
In vivo Quantitative Fluorescence Imaging Enabled by Spatial Frequency Domain Imaging for Enhanced Glioma Resection Mira Sibai 1,2, Brian Wilson 1,2 1University of Toronto Medical Biophysics, 101 College Street, Toronto Ontario M5G1L7, Canada 2Princess Margaret Cancer Center/Universal Health Network Molecular Imaging and Biophotonics, 610 University Avenue, Toronto Ontario M5G2M3, Canada
#138
Quantification study of the biochemical fingerprints issued from Raman Spectroscopy for the detection of the head and neck squamous cell carcinoma on mice tissues. Strola Samy Andrea1,2,3, Lamare Camille-Hélčne1, Henry Maxime1, Coll Jean-Luc1,2, Lantuejoul Sylvie2,1, Allier Cedric3, Dinten Jean-Marc3, Atallah Ihab2,1, Righini Christian2,1, Hamou Cynthia1, Bensaadi Lamia1 1CRI INSERM-UJF U823, Institut Albert Bonniot - La Tronche, France 2Centre Hospitalier Universitaire de Grenoble, OPTIC CLINIC Platform - Grenoble CEDEX 9, France 3CEA-LETI, DTBS-LISA - Grenoble, France
#139
Intravital Analysis of Vascular Permeability in the Bone Marrow of Calvarium Using Two-Photon Microscopy Malgorzata M. Kamocka 1, Amy L. Zollman 2, Kenneth Dunn 1, Nadia Carlesso 2 1Indiana Center for Biological Microscopy, Indiana University School of Medicine Medicine, 950 W. Walnut, Indianapolis, IN 46202, United States 2Indiana University School of Medicine Pediatrics, 1044 West Walnut, Indianapolis, IN 46202, United States
Optical projection tomography and selective plane illumination microscopy of intact mouse lungs and brains: added value to multimodal in vivo fungal infection imaging Greetje Vande Velde 1, Alexandre Robert-Moreno 2,3, Amy Hillen 1, Liesbeth Vanherp 1, James Sharpe 2,3,4, Uwe Himmelreich 1, Jim Swoger 2,3 1Biomedical MRI unit/ MoSAIC Imaging and Pathology, Herestraat 49 O&N1 box 505, 3000 Leuven, Belgium 2Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology EMBL-CRG Systems Biology Research Unit, Barcelona, Spain 3Universitat Pompeu Fabra (UPF), Barcelona, Spain 4Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
#171
Textural features of 18F-fluorodeoxyglucose positron emission tomography scanning in diagnosing aortic prosthetic graft infection Beukinga Jorn1,2, Saleem Ben 3, Zeebregts Clark 3, Slart Riemer 1,2 1Nuclear Medicine and Molecular Imaging Nuclear Medicine and Molecular Imaging - Groningen, Netherlands 2Faculty of Science and Technology Biomedical Photonic Imaging University of Twente - Enschede, Netherlands 3vascular surgery Departments of Surgery - Groningen, Netherlands
#172
Multimodal imaging for the non-invasive assessment of the response to antifungal therapy in a mouse model of invasive pulmonary aspergillosis Jennifer Poelmans 1, Amy Hillen 1, Liesbeth Vanherp 1, Johan Maertens 2, Greetje Vande Velde 1, Katrien Lagrou 2, Uwe Himmelreich 1 1Biomedical MRI unit / MoSAIC Department of Imaging and Pathology, Herestraat 49 box 505, 3000 Leuven, Belgium 2Clinical Bacteriology and Mycology Department of Microbiology and Immunology, Herestraat 49, 3000 Leuven, Belgium
#173
Optical imaging and modeling of the immune response to gastrointestinal bacterial infection Angelique Ale 1, Valerie Crepin 2, James Collins 2, Nicolas Constantinou 2, Ann Babtie 1, Gad Frankel 2, Michael Stumpf 1 1Imperial College London Centre for Integrative Systems Biology, London, United Kingdom 2Imperial College London Medical Research Council (MRC) Centre for Molecular Bacteriology and Infection, London, United Kingdom
#174
In vitro imaging of bacterial isolates using 18F-FDG positron emission tomography Marjolein Heuker 1, Jürgen Sijbesma 2, Johan de Jong 2, Hendrikus Boersma 2, Gert Luurtsema 2, Andor Glaudemans 2, Jan Maarten van Dijl 1, Marleen van Oosten 1, Riemer Slart 2 1University Medical Center Groningen Medical Microbiology, Hanzeplein 1, 9713GZ Groningen, Netherlands 2University Medical Center Groningen Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713GZ Groningen, Netherlands
#175
Evaluation of Clostridium difficile Infection severity with PET-CT image in a mouse model: pilot study Ana Villarejo 1, Lorena Cussó 1,2,3, Elena Reigadas 1, Patricia Muńoz 1,4, Emilio Bouza 1,4, Manuel Desco 1,2,3 1Instituto de Investigación Sanitaria Gregorio Marańón, Dr. Esquerdo 46, 28007 Madrid, Spain 2Universidad Carlos III de Madrid Departamento de Bioingeniería e Ingeniería Aeroespacial, Avda. Universidad 30, 28911 Madrid, Spain 3Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Monforte de Lemos 3-5, 28029 Madrid, Spain 4CIBER Enfermedades Respiratorias- CIBERES (CB06/06/0058) Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
#176
Importance of anesthesia protocol in the bioluminescence follow-up of infectious disease. Marc Vandamme 1, Thomas Chuzel 1, Violette Sanchez 2, Stephane Martin 1, Odile Flety 2, Aurelie Pager 1, Christophe Chabanel 2, Luc Magnier 1, Marie Foskolos 1, Oceane Petit 1, Bachra Rokbi 2, Emmanuel Chereul 1 1VOXCAN, 1 avenue Bourgelat, 69280 Marcy-L'Etoile, France 2SANOFI PASTEUR, Campus Mérieux, 69280 Marcy-l’Etoile, France
Active Tumor Targeting Using Riboflavin-Functionalized Polymers Tsvetkova Yoanna, Baues Maike, Al Rawashdeh Wa'el, Gremse Felix, Banala Srinivas, Lammers Twan, Kiessling Fabian
RWTH Aachen University Experimental Molecular Imaging - Aachen, Germany
#179
Pretreating metastatic tumors with anti-inflammatory drugs as a strategy to improve drug delivery Vertika Pathak, Larissa Yokota Rizzo, Fabian Kiessling, Twan Lammers
Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Pauwelsstraße 30,, 52074 Aachen, Germany
#180
Preclinical pharmacodynamics of anti-FAP-IL2v immunotherapy with [68Ga]DOTA-Siglec-9 in B16-FAP-melanoma mice Riikka Siitonen 1, Helena Virtanen 1, Heidi Liljenbäck 1,2, Olli Metsälä 1, Marika Karikoski 3, Pia Rantakari 3, Christian Klein 4, Tapan Nayak 4, Sirpa Jalkanen 3, Anne Roivainen 1,2 1Turku PET Centre, University of Turku & Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland 2Turku Center for Disease Modeling, University of Turku, Turku, Finland 3MediCity Research Laboratory, University of Turku, Turku, Finland 4F. Hoffmann-La Roche Ltd, Basel, Switzerland
#181
Non-invasive in vivo imaging of hypoxia in the growth of colorectal liver metastases Gieling Roben G.1,2, Telfer Brian A1, Morris David M3, Williams Kaye1,2 1Hypoxia & Therapeutics Group, Manchester Pharmacy School, University of Manchester - Manchester, United Kingdom 2CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester - Manchester, United Kingdom 3Wolfson Molecular Imaging Centre, Institute of Population Health, University of Manchester - Manchester, United Kingdom
#182
L- Ferritin targets breast cancer stem cells and delivers therapeutic and imaging agents. Simonetta Geninatti Crich, Laura Conti, Stefania Lanzardo, Roberto Ruiu, Juan Carlos Cutrin, Silvio Aime
University of Torino Molecular Biology and Health Sciences, via Nizza 52, 10126 Torino, Italy
#183
Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases and brain tumors: from bench to beside. Lucie Sancey 1, Shady Kotb 1, Sandrine Dufort 2, Francois Lux 1, Camille Verry 3, Géraldine Le Duc 2, Olivier Tillement 1 1Institut Lumičre Matičre, UMR5306 Univ. Lyon 1-CNRS Team FENNEC, 2 rue V. Grignard, 69622 Villeurbanne, France 2NH Theraguix Atrium, 69622 Villeurbanne, France 3CHU Grenoble Radiotherapy Department, 38041 Grenoble, France
#184
Multiparametric MRI approach for assessing therapeutic response to imatinib in Gastrointestinal Stromal Tumours (GIST) Consolino Lorena1,2, Longo Dario3, Arena Francesca4, Bardini Paola4, Blasi Francesco4, Sciortino Marianna1, Cabodi Sara1, Giovenzana Giovanni Battista2, Aime Silvio1 1Universitŕ di Torino, Department of Molecular Biotechnology and Health Sciences - Torino, Italy 2Cage Chemicals - Novara, Italy 3Institute of Biostructure and Bioimaging CNR - Torino, Italy 4University of Torino, Department of Molecular Biotechnology and Health Sciences, Center of Excellence for Preclinical Imaging (CEIP) - Colleretto Giacosa, Italy
#185
Simultaneous MRI and MR Spectroscopy of small volume (1 μl) intracerebral metabolites: a combined microdialysis and microcoil application.
Silvia Rizzitelli 1, Stefan Glöggler 1, Noël Pinaud 1, Gerard Raffard 1, Vanessa Zhendre 1, Veronique Bouchaud 1, Stephane Sanchez 1, Alan Wong 2, Yannick Cremillieux 1 1University of Bordeaux Centre de Resonance Magnétique des Systemes Biologiques, 146, rue Léo Saignat, 33076 Bordeaux, France 2CEA I2BM Neurospin, Gif-sur-Yvette, France
#186
Functionalized silica nanoparticles in the detection and treatment of Her2-positive breast cancer
Sara Belloli 1,2, Benedetta Riva 3, Paolo Rainone 1,2, Francesco Sudati 2, Marilena Ripamonti 1, Luigi Gianolli 2, Maria Carla Gilardi 1, Davide Prosperi 3, Rosa Maria Moresco 2,4 1Institute of Molecular Bioimaging and Physiology, National Researches Council (IBFM-CNR), Segrate, Italy 2IRCCS San Raffaele Scientific Institute Experimental Imaging Center, Milano, Italy 3University of Milan-Bicocca Department of Biotechnologies and Biosciences, Milano, Italy 4University of Milan-Bicocca Department of Medicine and Surgery, Monza, Italy
#187
MR-based quantification of small molecule release from a temperature sensitive drug delivery system Aleong Amanda1,2, Dou Yannan3, Allen Christine3, Jaffray David4,5,6, Zheng Jinzi1,2,7 1University Health Network/Techna Institute, Guided Therapeutics - Toronto, Canada 2University of Toronto, Institute of Biomaterials and Biomedical Engineering - Toronto, Canada 3University of Toronto, Department of Pharmaceutical Sciences - Toronto, Canada 4University Health Network, TECHNA Institute - Toronto, Canada 5University of Toronto, Department of Medical Biophysics - Toronto, Canada 6University of Toronto, Department of Radiation Oncology - Toronto, Canada 7Princess Margaret Cancer Centre, STTARR Innovation Centre - Toronto, Canada
#188
The therapeutic outcome of hyperthermia is influenced by the applied the heating source, the metabolic response pattern of tumor cells, and the time after therapy
Robert Ludwig 1, Francisco Teran 2, Ulf Teichgräber 3, Ingrid Hilger 3 1University Hospital Jena Experimental Radiology, Erlanger Allee 101, 07747 Jena, Germany 2IMDEA-Nanociencia - Campo Universitario de Cantoblanco, Campo Universitario de Cantoblanco, 28049 Madrid, Spain 3University Hospital Jena Experimental Radiology, Erlanger Allee 101, 07747 Jena, Germany
In vivo and ex vivo imaging to evaluate the effect of the Wnt signaling antagonist secreted frizzled-related protein 1 (SFRP1) on tumor growth and angiogenesis Sarah Christina Baetke 1, Josef Ehling 1, Matthias Bartneck 2, Diana Möckel 1, Martin Schlensog 3, Edgar Dahl 3, Fabian Kiessling 1, Twan Lammers 1 1RWTH Aachen University Department of Experimental Molecular Imaging, Pauwelsstr. 30, 52074 Aachen, Germany 2RWTH Aachen University Department of Medicine III, Pauwelsstr. 30, 52074 Aachen, Germany 3RWTH Aachen University Department of Pathology, Pauwelsstr. 30, 52074 Aachen, Germany
#226
Anti-CCL2 treatment induces vascular normalization and improves polymeric drug delivery to tumors Diana Möckel 1, Josef Ehling 1, Matthias Bartneck 2, Fabian Kiessling 1, Frank Tacke 2, Twan Lammers 1 1RWTH Aachen University Experimental Molecular Imaging, Pauwelsstraße 30, 52074 Aachen, Germany 2RWTH Aachen University Medicine III, Pauwelsstraße 30, 52074 Aachen, Germany
#227
HRG and anti-CCL2-treatment induce vascular normalization and improve drug delivery to tumors Maike Baues 1, Diana Möckel 1, Josef Ehling 1, Benjamin Theek 1, Matthias Bartneck 2, Frank Tacke 2, Fabian Kiessling 1, Twan Lammers 1 1RWTH Aachen University Institute for Experimental Molecular Imaging (ExMI), Pauwelsstrasse 30, 52074 Aachen, Germany 2RWTH Aachen University Medicine III, Pauwelsstrasse 30, 52074 Aachen, Germany
#228
First in mice ultrasound and photoacoustic imaging of orthotopic lung cancer: Novel onco-pharmacology approach Florian Raes 1, Julien Sobilo 1, Sharuja Natkunarajah 1, Dieter Fuchs 2, Philippe Trochet 2, Stephanie Lerondel 1, Alain Le Pape 1,3 1Phenomin-TAAM CIPA Centre for Small Animal Imaging CNRS UPS44 French National Center for Scientific Research Centre for Small Animal Imaging, 3b Rue de la Férolerie 45071 Orléans Cedex 02, Orléans, France 2FUJIFILM Visualsonics Inc., Joop Geesinkweg 140 1114 AB, Amsterdam, Netherlands 3Respiratory Pathology Study Center - CEPR INSERM U1100, Faculté de Médecine, Université F. Rabelais 10, boulevard Tonnellé 37032 Tours cedex, Tours, France
#229
A multimodal Imaging approach for longitudinal evaluation of bladder tumor development in an orthotopic murine model Scheepbouwer Chantal1, Meyer Sandra 2, Burggraaf Maroeska 1, Jose Jithin 2, Molthoff Carla1 1VU University Medical Center Radiology and Nuclear Medicine - Amsterdam, Netherlands 2FUJIFILM VisualSonics - Amsterdam, Netherlands
#230
Ischemia promotes murin colorectal liver metastases growth: In vivo documentation with preclinical imaging Desislava Germanova 1, Jiri Keirsse 2, Sandrine Delbauve 1, Pieter Demetter 3, Laurine Verset 3, Monia Bali 4, Sebastien Boutry 5, Lionel Larbanoix 5, Felicie Sherer 6, Gaetan van Simaeys 6, Gilles Doumont 6, Jo van Ginderachter 2, Vincent Donckier de Donceel 7, Veronique Flamand 1 1ULB IMI, Adrienne Bolland 8, 6041 Gosselies, Belgium 2VUB, Boul. de la Plaine 2, 1050 Brussels, Belgium 3Erasme hospital Anatomopathology, Brussels, Belgium 4Erasme hospital Radiology, Brussels, Belgium 5University Mons CMMI, Mons, Belgium 6ULB CMMI, Gosselies, Belgium 7Erasme hospital, Brussels, Belgium
#231
Sonoporation improves the accumulation and penetration of liposomes in tumors with low EPR
Benjamin Theek, Maike Baues, Diana Möckel, Fabian Kiessling, Twan Lammers
RWTH Aachen University Institute for Experimental Molecular Imaging (ExMI), Pauwelsstrasse 30, 52074 Aachen, Germany
#232
Characterization of an orthotopic mouse model of colorectal cancer model for multimodal imaging Sara Rapic 1, Christel Vangestel 1,2, Jeroen Verhaeghe 1, Rukun Hinz 3, Marleen Verhoye 3, Tim van Den Wyngaert 1,2, Patrick Pauwels 4,5, Steven Staelens 1, Sigrid Stroobants 1,2 1University of Antwerp Molecular Imaging Center Antwerp (MICA), Universiteitsplein 1, 2610 Wilrijk, Belgium 2Antwerp University Hospital Department of Nuclear Medicine, Wilrijkstraat 10, 2650 Edegem, Belgium 3University of Antwerp Bio-Imaging Lab (BIL), Universiteitsplein 1, 2610 Wilrijk, Belgium 4Antwerp University Hospital Department of Pathological Anatomy, Wilrijkstraat 10, 2650 Edegem, Belgium 5University of Antwerp Center for Oncological Research (CORE), Universiteitsplein 1, 2610 Wilrijk, Belgium
#233
Heterogeneity of murine tumors microenvironment characterized by MRI and Histology Agnieszka Drzał 1, Michał Gonet 1, Tomasz Skórka 2, Martyna Elas 1 1Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University Department of Biophysics, Gronostajowa 7, 30-387 Kraków, Poland 2Institute of Nuclear Physics, Polish Academy of Sciences Department of Magnetic Resonance Imaging, Radzikowskiego 152, 31-342 Kraków, Poland
#234
Optoacoustic imaging of blood vasculature and study of angiogenesis in orthotopic breast cancer models Quirós-Gonzalez Isabel1,2, Tomaszewski Michal 2,1, Joseph James 2,1, Bohndiek Sarah 2,1 1University of Cambridge Cancer Research UK Cambridge Institute - Cambridge, United Kingdom 2University of Cambridge Physics - Cambridge, United Kingdom
#235
TSPO PET IMAGING IN PRE-CLINICAL MODELS OF HUMAN GLIOMAS
Hayet Pigeon 1, Raphael Boisgard 1, Benoit Jego 1, Fabien Caillé 1, Frédéric Dollé 1, Andreas H. Jacobs 2, Alexandra Winkeler 1 1Inserm / CEA / Université Paris Sud, UMR 1023 – ERL 9218 CNRS, IMIV, Orsay, 4, place du Général Leclerc, 91400 Orsay, France 2European Institute for Molecular Imaging, Westfälische Wilhelms University, Waldeyerstr. 15, 48149 Münster, Germany
#236
Multimodality Imaging in Preclinical Prostate Stem Cell Antigen-Expressing Tumor Models Ralf Bergmann 1, Claudia Arndt 1, Anja Feldmann 1, Stefanie Koristka 1, Alexandra Kegler 1, Maik Schubert 1, Marc Cartellieri 2, Armin Ehninger 2, Domokos Máthé 3, Jens Pietzsch 1, Jörg Steinbach 1, Michael Bachmann 1,4 1Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328 Dresden, Germany 2Cellex Patient Treatment GmbH, Tatzberg 47, 01307 Dresden, Germany 3Semmelweis University Budapest Nanobiotechnology and In Vivo Imaging Center, Tűzoltó utca 37-47, Budapest, Hungary 4Technische Universität Dresden University Cancer Center, Tumorimmunology, Fetscherstraße 74, 01307 Dresden, Germany
In vivo monitoring of brain-activation patterns induced by optogenetic VTA-stimulation in rats: SPECT-imaging of regional cerebral blood flow versus BOLD fMRI Daniel Vincenz 1, Marta J. Brocka 1, Frank Angenstein 2, Frank W. Ohl 1, Michael T. Lippert 1, Jürgen Goldschmidt 1 1Leibniz-Institute for Neurobiology Systems Physiology of Learning, Brenneckestraße 6, 39118 Magdeburg, Germany 2German Center for Neurodegenerative Diseases, Magdeburg, Germany
#271
Glutamate levels mediate resting state cortical connectivity after prolonged barrel cortex activation Nathalie Just
AG Experimentelle Magnetische Kernresonanz Translational Research Imaging Center (TRIC), Albert-Schweitzer-Campus 1 - Gebäude A16, 48149 Münster, Germany
#272
Influence of repetitive transcranial magnetic stimulation on functional connectivity and hemodynamics in the rat brain Boonzaier Julia1, van Tilborg Geralda1, Bouts Mark2,3,4, Petrov Petar5, van Heijningen Caroline1, van Vliet Gerard1, van der Toorn Annette1, Neggers Sebastiaan5, Dijkhuizen Rick. M.1 1University Medical Center Utrecht, Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences - Utrecht, Netherlands 2Leiden University, Institute of Psychology, Department of Methodology & Statistics - Leiden, Netherlands 3Leiden University Medical Center, Department of Radiology - Leiden, Netherlands 4Leiden Institute for Brain and Cognition - Leiden, Netherlands 5University Medical Center Utrecht, Brain Center Rudolf Magnus, Department of Psychiatry - Utrecht, Netherlands
#273
Anesthesia dependent correlation of low-frequency fluctuations in BOLD and Local Field Potentials in the rat Claudia Hafeneger 1, Wenju Pan 2, Garth Thompson 2, Shella D. Keilholz 2, Mathias Hoehn 1,3 1Max Planck Institute for Metabolism research In-vivo-NMR, Gleueler Str. 50, 50931 Cologne, Germany 2Emory University/Georgia Institute of Technology Wallace H. Coulter Department of Biomedical Engineering, 1760 Haygood Dr, Suite W-230, Atlanta, Georgia 30322-4600, United States 3Leiden University Medical Center Department of Radiology, Leiden, Netherlands
#274
Effects of Ablation of TRPV1-expressing Neurons via Resinifera-Toxin Administration on Central Temperature Processing in the Rat Wank Isabel, Kutsche Lisa, Kreitz Silke, Hess Andreas
University of Erlangen-Nuremberg Institute of Pharmacology and Toxicology - Erlangen, Germany
#275
Histological correlates of MRI contrast in patients with Alzheimer’s Disease Bulk Marjolein1,2, Abdelmoula Walid M.1, van der Graaf Linda M.1,2, van Buchem Mark A.1, Voorn Pieter3, Dijkstra Jouke1, van der Weerd Louise1,2 1Leiden University Medical Center, Radiology - Leiden, Netherlands 2Leiden University Medical Center, Human Genetics - Leiden, Netherlands 3VU University Medical Center, Anatomy and Neurosciences - Amsterdam, Netherlands
#276
Differential effects of different anesthetics and stimulation paradigms on the lateral and medial pain systems in rats: an fMRI study
Tanja Makaroa, Marina Sergeeva, Andreas Hess
Friedrich Alexander University I. f. Pharmacology, Fahrstrasse 17, 91054 Erlangen, Germany
#277
Validation of MRI-based digital atlases registration for the study of neurological disorders in mouse. Adrien Riou 1,2, Michael Diedenhofen 1, Michael Sué 1, Dirk Wiedermann 1, Mathias Hoehn 1,2 1Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany 2Leiden University Medical Center, Albinusdreef 2, 2333 Leiden, Netherlands
#278
Mapping resting state networks in rats using a novel simultaneous PET/MR approach André Thielcke 1, Mario Amend 1, Suril Gohel 2, Bharat Biswal 2, Bernd J. Pichler 1, Hans F. Wehrl 1 1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany 2Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102, United States
Rat brain activity measured by simultaneous [18F]FDG-PET and BOLD-fMRI using a single scanning session protocol Mario Amend 1, Tadashi Watabe 2,1, André Thielcke 1, Bernd J. Pichler 1, Hans F. Wehrl 1 1Eberhard Karls University of Tuebingen Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Roentgenweg 13, 72076 Tuebingen, Germany 2Osaka University Graduate School of Medicine Nuclear Medicine and Tracer Kinetics, Yamadaoka 2-2, Osaka, Suita 565-0871, Japan
#281
Light-induced activation of the visual network by optogenetic fMRI (ofMRI)
Florian Schmid 1, Lydia Wachsmuth 1, Franziska Albers 1, Nathalie Just 1, Miriam Schwalm 2, Albrecht Stroh 2, Cornelius Faber 1 1University of Münster Department of Clinical Radiology, Albert-Schweitzer-Campus 1 Geb A16, 48149 Münster, Germany 2Johannes-Gutenberg-University Mainz Focus Program Translational Neuroscience & Institute for Microscopic Anatomy and Neurobiology, Mainz, Germany
#282
Multi-modal imaging and analysis pipeline for post-mortem brain research Linda M. van der Graaf 1,2, Walid M. Abdelmoula 1, Marjolein Bulk 1,2, Mathijs Buijs 1, Andrew Webb 1, Itamar Ronen 1, Mark A. van Buchem 1, Jouke Dijkstra 1, Wim Wiarda 3, Louise van der Weerd 1,2 1Leiden University Medical Center Radiology, Einthovenweg 20, 2333ZC Leiden, Netherlands 2Leiden University Medical Center Human Genetics, Einthovenweg 20, 2333ZC Leiden, Netherlands 3Netherlands Forensic Institute, Laan van Ypenburg 6, 2497GB Den Haag, Netherlands
#283
Mapping dynamics of epileptic seizures in GAERS using simultaneous BOLD fMRI and optical Ca2+ recordings Lydia Wachsmuth 1, Florian Schmid 1, Franziska Albers 1, Annika Lüttjohann 2, Thomas Budde 2, Cornelius Faber 1 1University of Münster Clinical Radiology, Albert-Schweitzer-Campus 1, 48149 Münster, Germany 2University of Münster Physiology I, Robert-Koch-Str. 27a, 48149 Münster, Germany
#284
Novel Random Forest based framework enables the segmentation of cerebral ischemic regions using multi-parametric MRI Katiyar Prateek1, Castaneda Vega Salvador1, Patzwaldt Kristin1, Russo Francesca2, Poli Sven2, Ziemann Ulf2, Disselhorst Jonathan A.1, Pichler Bernd J.1 1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen - Tuebingen, Germany 2Department of Neurology & Stroke, University Hospital Tuebingen - Tuebingen, Germany
#285
Biomolecular investigation of neurodegenerative diseases and brain plasticity with mass spectrometry imaging Ogrinc Potočnik Nina1, Praet Jelle2, Hamaide Julie2, van der Linden Annemie2, Heeren Ron M. A.1 1M4I Institute, Maastricht University, Division of Imaging Mass Spectrometry - Maastricht, Netherlands 2University of Antwerp, Bio-Imaging Lab - Wilrijk, Belgium
#286
In vivo and ex vivo astrocyte calcium imaging in mouse substantia nigra. Lina Malinouskaya 1, Jesus Pasculal-Brazo 1, An-Sofie Desmet 2, Chris van Den Haute 1,3, Pieter Vanden Berghe 2, Veerle Baekelandt 1 1Katholieke Universiteit Leuven Neurobiology and Gene Therapy, Kapucijnenvoer 33, 3000 Leuven, Belgium 2Katholieke Universiteit Leuven Laboratory for Enteric NeuroScience, TARGID, Herestraat 49, 3000 Leuven, Belgium 3Katholieke Universiteit Leuven Viral Vector Core, Kapucijnenvoer 33, 3000 Leuven, Belgium
#287
Multiparametric Imaging of Ischemic Stroke using [89Zr]-Desferal-EPO-PET/MRI in combination with Gaussian Mixture Modeling enables unsupervised lesions identification. Castaneda Vega Salvador1, Prateek Katiyar1, Russo Francesca2, Maurer Andreas1, Patzwaldt Kristin1, Poli Sven2, Calaminus Carsten1, Disselhorst Jonathan A.1, Ziemann Ulf2, Pichler Bernd J.1 1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhart Karls University Tuebingen - Tuebingen, Germany 2Hertie Institute for Clinical Brain Research, Department for Neurology, University Clinic Tuebingen - Tuebingen, Germany
#288
Non-invasive high resolution photoacoustic imaging of oxygen saturation and contrast agents in the mouse brain Andrew Heinmiller 1, Alex Forbrich 1, Carly Warren 1, Jithin Jose 2, Andrew Needles 1 1FUJIFILM VisualSonics, Inc., 3080 Yonge St, Suite 6100, Toronto Ontario M4N 3N1, Canada 2FUJIFILM VisualSonics, Inc., Joop Geesinkweg 140, 1114 AB Amsterdam, Netherlands
#289
Tracer kinetic modelling of [18F]florbetapir in humans Golla Sandeep1, Verfaillie Sander2, Adriaanse Sofie1, Zwan Marissa2, Schuit Robert C.1, Timmers Tessa1,2, Groot Colin1, Schober Patrick3, Schwarte Lothar3, Scheltens Philip1, van der Flier Wiesje1,4, Windhorst Albert D.1, Lammertsma Adriaan A.1, van Berckel Bart1, Boellaard Ronald1 1VU University Medical Center, Neuroscience Campus Amsterdam, Dept. of Radiology and Nuclear Medicine - Amsterdam, Netherlands 2VU University Medical Center, Neuroscience Campus Amsterdam, Dept. of Alzheimer Center & Neurology - Amsterdam, Netherlands 3VU University Medical Center, Neuroscience Campus Amsterdam, Dept. of Anaesthesiology - Amsterdam, Netherlands 4VU University Medical Center, Neuroscience Campus Amsterdam, Dept. of Epidemiology & Biostatistics - Amsterdam, Netherlands
#290
Mapping stimulus-evoked glutamate and lactate changes in the mouse brain using spectroscopic imaging Aline Seuwen1, Aileen Schröter 1, Markus Rudin 1,2 1Institute for Biomedical Engineering University of Zurich & ETH - Zurich, Switzerland 2Institute of Pharmacology and Toxicology University of Zurich - Zurich, Switzerland
#291
Imaging synaptic memory formation using a novel drug-controlled reporter Adrian Szum 1, Oleksii Nikolaienko 1, Sudarshan Patil 1, Michael Lin 2, Clive R. Bramham 1 1University of Bergen Department of Biomedicine and KG Jebsen Centre for Research on Neuropsychiatric Disorders, Jonas Lies vei 91, 5020 Bergen, Norway 2Stanford University Department of Neurobiology, 1291 Welch Rd, CCSR 2105, Stanford, California CA 94305-5164, United States
#292
In vivo evaluation of the enantio-selectivity at SV2A protein through a new and efficient synthesis of [18F]UCB-H Guillaume Becker 1, Corentin Warnier 1, Marie Elisa Serrano 1, Mohamed Ali Bahri 1, Joel Aerts 1, Joel Mercier 2, Andre Luxen 1, Christian Lemaire 1, Alain Plenevaux 1 1University of Liege Cyclotron Research Center, allee du six Aout, 4000 Liege, Belgium 2UCB Pharma SPRL Parkinson’s disease group, Braine L’Alleud, Belgium
#293
Tracking therapeutic cells using K-edge imaging in a rodent model of stroke
Ong Elodie1, Rositi Hugo1, Weber Loriane1, Chauveau Fabien2, Cho Tae-Hee1, Olivier Cecile1, Langer Max1, Peyrin Francoise1, Nighoghossian Norbert1, Berthezene Yves1, Parola Stephane3, Wiart Marlčne4 1CREATIS UMR CNRS 5220; U1044 Inserm; Université de Lyon; INSA de Lyon - Lyon, France 2CRNL, CNRS UMR 5292, Inserm UMR_S 1028, Université Lyon 1 - Lyon, France 3Laboratoire de Chimie, ENS Lyon, CNRS UMR 5182, Université Lyon 1 - Lyon, France 4CarMeN Inserm U1060 - Lyon, France
Comparison of 18F-RGD and 68Ga-RGD for PET imaging of angiogenesis in a mouse model bearing human glioblastoma Provost Claire1,2, Prignon Aurélie2, Bouteiller Cédric1, Talbot Jean-Noël2,3 1PETNET Solutions - Lisses, France 2LIMP UMS 028 UPMC - Paris, France 3Department of Nuclear Medicine APHP - Paris, France
#238
Magnetic Resonance Imaging of the Pancreas in a Transgenic Mouse Model of Pancreatic Carcinogenesis Conny F. Waschkies 1,2, Theresia Reding 1, Gitta Maria Seleznik 1, Udo Ungethuem 1, Rolf Graf 1 1University Hospital Zurich Division of Visceral and Transplantation Surgery, Sternwartstrasse 6 E4, 8091 Zurich, Switzerland 2ETH and University of Zurich Institute for Biomedical Engineering, Wolfgang-Pauli-Str. 27, HIT E22.3, 8093 Zurich, Switzerland
#239
Preclinical evaluation of the use of MRI and PET based markers of hypoxia in the prediction of response to hypoxia-selective cytotoxins. Victoria Tessyman 1,2, Duncan Forster 3, Katherine Finegan 1,2, Ross Little 1, Babur Muhammad 1,2, Marie-Claude Asselin 1,3, James O'Connor 1, Kaye Williams 1,2 1University of Manchester CRUK and EPSRC Cancer Imaging Centre, Manchester, United Kingdom 2University of Manchester School of Pharmacy, Stopford Building, Manchester, M13 9PT, United Kingdom 3University of Manchester Institute of Population Health, Stopford Building, Manchester, M13 9PT, United Kingdom
#240
Longitudinal in vivo bioluminescence imaging of tumour response to liposome-encapsulated butyrate therapy Gomez Ramirez Ana1, Bofinger Robin2, Zaw-Thin May1, Connell John1, Patrick Peter Stephen1, Hailes Helen2, Tabor Alethea2, Lythgoe Mark1, Kalber Tammy1, Bell Jimmy D3 1UCL, Centre for Advanced Biomedical Imaging (CABI). Division of Medicine - London, United Kingdom 2UCL, Division of Chemistry - London, United Kingdom 3University of Westminister, Life sciences - London, United Kingdom
#241
Inflammatory Microenvironment Supports Malignant Behaviour in Glioblastoma: Monitoring of Microglial Activation Status with [11C]PK11195 Catia Neto 1,2, Carvalheiro Tiago 3, Artur Paiva 3, Jose Ferrao 4, Isabel M Carreira 4,5, Maria Teresa Cruz 6,7, Antero Abrunhosa 1,2,7, Carlos Fontes-Ribeiro 2, Celia Gomes 2,7,5 1Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra, Portugal 2Institute for Biomedical Imaging and Life Sciences (IBILI) Pharmacology and Experimental Therapeutics, Coimbra, Portugal 3Portuguese Institute of Blood Blood and Transplantation Center of Coimbra, Coimbra, Portugal 4University of Coimbra Cytogenetic and Genomic Laboratory, Coimbra, Portugal 5Faculty of Medicine University of Coimbra Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Coimbra, Portugal 6University of Coimbra Faculty of Pharmacy and Centre for Neuroscience and Cell Biology (CNC), Coimbra, Portugal 7University of Coimbra CNC.IBILI, Coimbra, Portugal
#242
Imageable spontaneously metastasizing orthotopic rodent models of canine mammary carcinoma – a new appraoch in the anti cancer drug development path Sebastian Gehrig1, Antonia Geyer1, Julia Maier1, Simone Mezgolits1, Martina Anton2, Hellmén Eva3, Manfred Ogris1 1Laboratory of MacroMolecular Cancer Therapeutics, Departement of Pharmaceutical Chemistry, University of Vienna - Vienna, Austria 2Institute of Molecular Immunology & Experimental Oncology - München, Germany 3SLU, Department of Anatomy, Physiology and Biochemistry - Uppsala, Sweden
#243
DETECTION OF TUMORAL NETRIN-1 PROTEIN LEVELS USING ULTRASOUND MICROBUBBLE CONTRAST AGENTS: IN VITRO VALIDATION Jennifer Wischhusen 1, Jean-Guy Delcros 2, Patrick Mehlen 2, Frederic Padilla 1 1INSERM U1032 LabTAU, 151 Cours Albert Thomas, 69003 Lyon, France 2INSERM U1052 CRCL, 28 rue Laennec, 69008 Lyon, France
#244
Live Tumor Cell Imaging by Indocyanine Green through Passive Tumor Cell-targeting without the Need for a Targeting Moiety Onda Nobuhiko 1,2, Kimura Masayuki 2, Yoshida Toshinori 2, Shibutani Makoto 2 1Olympus Corporation R&D Group, 2-3 Kuboyama-cho, Tokyo, Hachioji 192-8512, Japan 2Tokyo University of Agriculture and Technology Laboratory of Veterinary Pathology, 3-5-8 Saiwai-cho, Tokyo, Fuchu 183-8509, Japan
#245
ADC VALUE AS A BIOMARKER FOR ASSESSEMENT OF PROSTATE CANCER AGGRESSIVENESS IN PERIPHERAL ZONE Luca Basso, Marta Baglietto, Alberto Del Prato, Michela Perinetti, Francesca Rosa, Carlo Emanuele Neumaier
IRCCS San Martino IST Radiology Dpt, L.go Rosanna Benzi 10, 16100 Genova, Italy
#246
Generation and evaluation of multidrug resistant, metastatic and imageable iRFP-expressing 4T1 breast carcinoma xenografts Okan Tezcan, Larissa Y. Rizzo, Fabian Kiessling, Twan Lammers
University Hospital RWTH Aachen Helmholtz Institute for Biomedical Engineering, Pauwelsstrasse 30, 52074 Aachen, Germany
#247
Intraoperative imaging of pancreatic tumour lesions by Cetuximab conjugated to NIRF dyes.
Mara Saccomano 1, Marieke Stammes 2,3, Alan Chan 3, Frauke Alves 1,4,5, Joanna Napp 1,4,5 1Max-Planck-Institute for Experimental Medicine Molecular Biology of Neuronal Signals, Hermann-Rein Str. 3, 37075 Göttingen, Germany 2Leiden University Medical Center Department of Radiology, Albinusdreef 2, 2333 Leiden, Netherlands 3Percuros BV, Leiden, Netherlands 4University Medicine Göttingen Diagnostic and Interventional Radiology, Robert Koch Str. 40, 37075 Göttingen, Germany 5University Medicine Göttingen Hematology and Medical Oncology, Robert Koch Str. 40, 37075 Göttingen, Germany
#248
Priming tumor blood vessels and the tumor microenvironment to improve nanomedicine-mediated drug delivery Tarun Ojha, Josef Ehling, Paolo Ceccarini, Diana Möckel, Fabian Kiessling, Twan Lammers
University Clinic-RWTH - Aachen University Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Pauwelsstrasse 30, 52074 Aachen, Germany
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